Dr Danilo Perrotti MD, PhD

460 W. 12th Ave
860 Biomedical Research Tower
Columbus, OH 43210

Phone: (614) 292-3255

Email: danilo.perrotti@osumc.edu

Current OSU Appointment

Associate Professor, Molecular Virology, Immunology & Medical Genetics

Abstracts

Cimino L, Falcioni R, Rizzo MG, Perrotti D, Sacchi A. 1990. "Cloning of Beta 4 integrin subunit." Abstract. Cell Biology - International Reports, Abstract Supplement Third European Congress of Cell Biology, 14.

Perrotti D, Cimino L, Ferrari S, Sacchi A. 1990. "Expression of cellular oncogenes in murine carcinoma cells with different metastatic potential." Abstract. Supplement to Journal of Cancer Research and Clinical Oncology, 116: 174.

Tibursi G, Gentileschi MP, Falcioni R, Cimino L, Perrotti D, Sacchi A. 1990. "Metastatic phenotype: growth factor dependence and integrin expression." Abstract. Cell Biology - International Reports, Abstract Supplement Third European Congress of Cell Biology, 14.

Certifications

1991 - present

Board Certification: Italian Medical Board

Degrees

1984	B.S., Liceo Scientifico Statale F. D'Assisi

1991	M.D., University of Rome La Sapienza

1997	Ph.D., University of L'Aquila, Biotechnology

Editorial Activities

Associate Editor

2007 - present

Cancer Research. (Journal)

Editorial Board

2009 - present

Cell Death & Disease. (Journal)

2008 - present

The Open Cell Signaling Journal. (Journal)

Review Board

2004 - present

Medical Science Monitor Journal. (Journal)

Honors

1990 - 1991

Fellow, Fellowship. Italian Ministry of Health. University of Rome La Sapienza, Rome, Italy.

1992 - 1995

Fellow, Fellowship. Italian Ministry of Universities and Scientific Research. University of L'Aquila, L'Aquila, Italy.

1994	Individual Award "P. Bolognesi". Board of Physicians of Rome- Italy. University of L'Aquila, L'Aquila, Italy. Subject: Award for young investigator in Cancer Research

1997 - 1999

Fellow, Fellowship. American Italian Foundation for Cancer Research. Thomas Jefferson University, Philadelphia, PA, United States.

2002	Elsa U. Pardee Foundation for Cancer Research Grant Award. Elsa U. Pardee. Thomas Jefferson University, Philadelphia, PA, United States.

2003	2003 Lauri Strauss Leukemia Research Foundation Grant Award.

2005 - 2006

OSUCCC Research Enhancement and Assistance Program (REAP) Award.

Languages

English: Standard (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)

Italian: (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)

Memberships

1996 - present

Active Member. American Association for Cancer Research (AACR)

1996 - present

Member. American Association for the Advancement of Science (AAAS)

1997 - present

Member. American Society for Cell Biology (ASCB)

2000 - present

Member. American Society of Hematology (ASH)

Peer Reviewed Journal Articles

Perrotti, D; Cimino, L; Falcioni, R; Tibursi, G; Gentileschi, M, P; Sacchi, A. 1990. Metastatic phenotype: growth factor dependence and integrin expression. Anticancer research. Vol. 10, no. 6: 1587-97.

Perrotti, D; Cimino, L; Ferrari, S; Sacchi, A. 1991. Differential expression of transforming growth factor-beta 1 gene in 3LL metastatic variants. Cancer research. Vol. 51, no. 20: 5491-4.

Citro, G; Perrotti, D; Cucco, C; D'Agnano, I; Sacchi, A; Zupi, G; Calabretta, B. 1992. Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proceedings of the National Academy of Sciences of the United States of America. Vol. 89, no. 15: 7031-5.

Perrotti, D; Melotti, P; Skorski, T; Casella, I; Peschle, C; Calabretta, B. 1995. Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity. Molecular and cellular biology. Vol. 15, no. 11: 6075-87.

Piaggio, G; Farina, A; Perrotti, D; Manni, I; Fuschi, P; Sacchi, A; Gaetano, C. 1995. Structure and growth-dependent regulation of the human cyclin B1 promoter. Experimental cell research. Vol. 216, no. 2: 396-402.

Skorski, T; Nieborowska-Skorska, M; Szczylik, C; Kanakaraj, P; Perrotti, D; Zon, G; Gewirtz, A; Perussia, B; Calabretta, B. 1995. C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis. Cancer research. Vol. 55, no. 11: 2275-8.

Perrotti, D; Bellon, T; Trotta, R; Martinez, R; Calabretta, B. 1996. A cell proliferation-dependent multiprotein complex NC-3A positively regulates the CD34 promoter via a TCATTT-containing element. Blood. Vol. 88, no. 9: 3336-48.

Skorski, T; Nieborowska-Skorska, M; Wlodarski, P; Perrotti, D; Martinez, R; Wasik, M, A; Calabretta, B. 1996. Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. Vol. 93, no. 23: 13137-42.

Bellon, T; Perrotti, D; Calabretta, B. 1997. Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter. Blood. Vol. 90, no. 5: 1828-39.

Cimino, L; Perrotti, D; D'Agostino, G; Falcioni, R; Sacchi, A. 1997. Beta 4 integrin subunit expression is downregulated in low metastatic carcinoma variants. Cancer detection and prevention. Vol. 21, no. 2: 158-66.

Lanza-Jacoby, S; Sedkova, N; Phetteplace, H; Perrotti, D. 1997. Sepsis-induced regulation of lipoprotein lipase expression in rat adipose tissue and soleus muscle. Journal of lipid research. Vol. 38, no. 4: 701-10.

Martinez, R; Venturelli, D; Perrotti, D; Veronese, M, L; Kastury, K; Druck, T; Huebner, K; Calabretta, B. 1997. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. Cancer research. Vol. 57, no. 6: 1180-7.

Salomoni, P; Perrotti, D; Martinez, R; Franceschi, C; Calabretta, B. 1997. Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity. Proceedings of the National Academy of Sciences of the United States of America. Vol. 94, no. 7: 3296-301.

Skorski, T; Bellacosa, A; Nieborowska-Skorska, M; Majewski, M; Martinez, R; Choi, J, K; Trotta, R; Wlodarski, P; Perrotti, D; Chan, T, O; Wasik, M, A; Tsichlis, P, N; Calabretta, B. 1997. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. The EMBO journal. Vol. 16, no. 20: 6151-61.

Skorski, T; Nieborowska-Skorska, M; Wlodarski, P; Perrotti, D; Hoser, G; Kawiak, J; Majewski, M; Christensen, L; Iozzo, R, V; Calabretta, B. 1997. Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides. Journal of the National Cancer Institute. Vol. 89, no. 2: 124-33.

Skorski, T; Perrotti, D; Nieborowska-Skorska, M; Gryaznov, S; Calabretta, B. 1997. Antileukemia effect of c-myc N3'P5' phosphoramidate antisense oligonucleotides in vivo. -->. Proceedings of the National Academy of Sciences of the United States of America. Vol. 94, no. 8: 3966-71.

Perrotti, D; Bonatti, S; Trotta, R; Martinez, R; Skorski, T; Salomoni, P; Grassilli, E; Lozzo, R, V; Cooper, D, R; Calabretta, B. 1998. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. The EMBO journal. Vol. 17, no. 15: 4442-55.

Ratajczak, M, Z; Perrotti, D; Melotti, P; Powzaniuk, M; Calabretta, B; Onodera, K; Kregenow, D, A; Machalinski, B; Gewirtz, A M. 1998. Myb and ets proteins are candidate regulators of c-kit expression in human hematopoietic cells. Blood. Vol. 91, no. 6: 1934-46.

Grassilli, E; Salomoni, P; Perrotti, D; Franceschi, C; Calabretta, B. 1999. Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction. Cancer research. Vol. 59, no. 10: 2451-6.

Iozzo, R, V; Chakrani, F; Perrotti, D; McQuillan, D, J; Skorski, T; Calabretta, B; Eichstetter, I. 1999. Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. Vol. 96, no. 6: 3092-7.

Cirinna, M; Trotta, R; Salomoni, P; Kossev, P; Wasik, M; Perrotti, D; Calabretta, B. 2000. Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation. Blood. Vol. 96, no. 12: 3915-21.

Manzella, L; Gualdi, R; Perrotti, D; Nicolaides, N, C; Girlando, G; Giuffrida, M, A; Messina, A; Calabretta, B. 2000. The interferon regulatory factors 1 and 2 bind to a segment of the human c-myb first intron: possible role in the regulation of c-myb expression. Experimental cell research. Vol. 256, no. 1: 248-56.

Perrotti, D; Iervolino, A; Cesi, V; Cirinna, M; Lombardini, S; Grassilli, E; Bonatti, S; Claudio, P, P; Calabretta, B. 2000. BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway. Molecular and cellular biology. Vol. 20, no. 16: 6159-69.

Venturelli, D; Cesi, V; Ransac, S; Engelhard, A; Perrotti, D; Calabretta, B. 2000. The nucleoside diphosphate kinase activity of DRnm23 is not required for inhibition of differentiation and induction of apoptosis in 32Dcl3 myeloid precursor cells. Experimental cell research. Vol. 257, no. 2: 265-71.

Iervolino, Angela; Santilli, Giorgia; Trotta, Rossana; Guerzoni, Clara; Cesi, Vincenzo; Bergamaschi, Anna; Gambacorti-Passerini, Carlo; Calabretta, Bruno; Perrotti, Danilo. 2002. hnRNP A1 nucleocytoplasmic shuttling activity is required for normal myelopoiesis and BCR/ABL leukemogenesis. Molecular and cellular biology. Vol. 22, no. 7: 2255-66.

Perrotti, Danilo; Calabretta, Bruno. 2002. Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins. Oncogene. Vol. 21, no. 56: 8577-83.

Perrotti, Danilo; Cesi, Vincenzo; Trotta, Rossana; Guerzoni, Clara; Santilli, Giorgia; Campbell, Kenneth; Iervolino, Angela; Condorelli, Fabrizio; Gambacorti-Passerini, Carlo; Caligiuri, Michael, A; Calabretta, Bruno. 2002. BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2. Nature genetics. Vol. 30, no. 1: 48-58.

Keeshan, Karen; Santilli, Giorgia; Corradini, Francesca; Perrotti, Danilo; Calabretta, Bruno. 2003. Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation. Blood. Vol. 102, no. 4: 1267-75.

Marcucci, Guido; Perrotti, Danilo; Caligiuri, Michael A. 2003. Understanding the molecular basis of imatinib mesylate therapy in chronic myelogenous leukemia and the related mechanisms of resistance. Commentary re: A. N. Mohamed et al., The effect of imatinib mesylate on patients with Philadelphia. Clinical cancer research : an official journal of the American Association for Cancer Research. Vol. 9, no. 4: 1248-52.

Perrotti, Danilo; Trotta, Rossana; Calabretta, Bruno. 2003. Altered mRNA translation: possible mechanism for CML disease progression. Cell Cycle. Vol. 2, no. 3: 177-80.

Trotta, Rossana; Vignudelli, Tatiana; Candini, Olivia; Intine, Robert, V; Pecorari, Luisa; Guerzoni, Clara; Santilli, Giorgia; Byrom, Mike, W; Goldoni, Silvia; Ford, Lance, P; Caligiuri, Michael, A; Maraia, Richard, J; Perrotti, Danilo; Calabretta, Bruno. 2003. BCR/ABL activates mdm2 mRNA translation via the La antigen. Cancer cell. Vol. 3, no. 2: 145-60.

Truong, Bao-Tran, H; Lee, Young-Jin; Lodie, Tracey, A; Park, Dorothy, J; Perrotti, Danilo; Watanabe, Naohide; Koeffler, H Phillip; Nakajima, Hideaki; Tenen, Daniel, G; Kogan, Scott C. 2003. CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. Blood. Vol. 101, no. 3: 1141-8.

Calabretta, Bruno; Perrotti, Danilo. 2004. The biology of CML blast crisis. Blood. Vol. 103, no. 11: 4010-22.

Perrotti, Danilo; Calabretta, Bruno. 2004. Translational regulation by the p210 BCR/ABL oncoprotein. Oncogene. Vol. 23, no. 18: 3222-9.

Perrotti, Danilo; Marcucci, Guido; Caligiuri, Michael A. 2004. Loss of C/EBP alpha and favorable prognosis of acute myeloid leukemias: a biological paradox. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Vol. 22, no. 4: 582-4.

Liu, Shujun; Shen, Tiansheng; Huynh, Lenguyen; Klisovic, Marko, I; Rush, Laura, J; Ford, Jamie, L; Yu, Jianhua; Becknell, Brian; Li, Yu; Liu, Chunhui; Vukosavljevic, Tamara; Whitman, Susan, P; Chang, Kun-Sang; Byrd, John, C; Perrotti, Danilo; Plass, Christoph; Marcucci, Guido. 2005. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer research. Vol. 65, no. 4: 1277-84.

Marcucci, Guido; Baldus, Claudia, D; Ruppert, Amy, S; Radmacher, Michael, D; Mrozek, Krzysztof; Whitman, Susan, P; Kolitz, Jonathan, E; Edwards, Colin, G; Vardiman, James, W; Powell, Bayard, L; Baer, Maria, R; Moore, Joseph, O; Perrotti, Danilo; Caligiuri, Michael, A; Carroll, Andrew, J; Larson, Richard, A; de la Chapelle, Albert; Bloomfield, Clara D. 2005. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Vol. 23, no. 36: 9234-42.

Neviani, Paolo; Santhanam, Ramasamy; Trotta, Rossana; Notari, Mario; Blaser, Bradley, W; Liu, Shujun; Mao, Hsiaoyin; Chang, Ji Suk; Galietta, Annamaria; Uttam, Ashwin; Roy, Denis, C; Valtieri, Mauro; Bruner-Klisovic, Rebecca; Caligiuri, Michael, A; Bloomfield, Clara, D; Marcucci, Guido; Perrotti, Danilo. 2005. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer cell. Vol. 8, no. 5: 355-68.

Perrotti, D; Turturro, F; Neviani, P. 2005. BCR/ABL, mRNA translation and apoptosis. Cell death and differentiation. Vol. 12, no. 6: 534-40.

47. Becknell B., Hughes TL., Freud AG., Blaser BW, Yu J, Trotta R., Mao HC., Caligiuri de Jesús ML, Alghothani M, Benson, Jr. DM, Lehman A, Jarjoura D, Perrotti D, Bates MD, and Caligiuri MA. 2006. The Hlx homeobox transcription factor negatively regulates interferon-? ?production in monokine-activated natural killer cells. Blood.

49. Liu Z., Liu, S., William B., Perrotti D., Paschka P., Klisovic R., Byrd JC., Chan KK., G. Marcucci G. 2006. Characterization of In-Vitro and In-Vivo Hypomethylating Effect of Decitabine in Acute Myeloid Leukemia by a Rapid, Specific and Sensitive LC-MS/MS Method. Nucl. Acid. Res..

Chiu, Shih-Jiuan; Liu, Shujun; Perrotti, Danilo; Marcucci, Guido; Lee, Robert J. 2006. Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes. Journal of controlled release : official journal of the Controlled Release Society. Vol. 112, no. 2: 199-207.

Guerzoni, Clara; Bardini, Michela; Mariani, Samanta, A; Ferrari-Amorotti, Giovanna; Neviani, Paolo; Panno, Maria Luisa; Zhang, Ying; Martinez, Robert; Perrotti, Danilo; Calabretta, Bruno. 2006. Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells. Blood. Vol. 107, no. 10: 4080-9.

Lee, Young-Jin; Jones, Letetia, C; Timchenko, Nikolai, A; Perrotti, Danilo; Tenen, Daniel, G; Kogan, Scott C. 2006. CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities. Blood. Vol. 108, no. 7: 2416-9.

Notari, Mario; Neviani, Paolo; Santhanam, Ramasamy; Blaser, Bradley, W; Chang, Ji-Suk; Galietta, Annamaria; Willis, Anne, E; Roy, Denis, C; Caligiuri, Michael, A; Marcucci, Guido; Perrotti, Danilo. 2006. A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation. Blood. Vol. 107, no. 6: 2507-16.

Paschka, Peter; Marcucci, Guido; Ruppert, Amy, S; Mrozek, Krzysztof; Chen, Hankui; Kittles, Rick, A; Vukosavljevic, Tamara; Perrotti, Danilo; Vardiman, James, W; Carroll, Andrew, J; Kolitz, Jonathan, E; Larson, Richard, A; Bloomfield, Clara, D; Bloomfield, Clara D. 2006. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Vol. 24, no. 24: 3904-11.

Perrotti D. and Neviani P. 2006. mRNA metabolism to Cancer therapy: CML shows the way. Clin. Cancer Res..

Perrotti, D; Neviani, P. 2006. ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia. British journal of cancer. Vol. 95, no. 7: 775-81.

Becknell, Brian; Hughes, Tiffany, L; Freud, Aharon, G; Blaser, Bradley, W; Yu, Jianhua; Trotta, Rossana; Mao, Hsiaoyin, C; Caligiuri de Jesus, Marie, L; Alghothani, Mohamad; Benson, Don M Jr; Lehman, Amy; Jarjoura, David; Perrotti, Danilo; Bates, Michael, D; Caligiuri, Michael A. 2007. Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells. Blood. Vol. 109, no. 6.

Caligiuri, Michael, A; Briesewitz, Roger; Yu, Jianhua; Wang, Lisheng; Wei, Min; Arnoczky, Kristy, J; Marburger, Trent, B; Wen, Jing; Perrotti, Danilo; Bloomfield, Clara, D; Whitman, Susan P. 2007. Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. Blood. Vol. 110, no. 3.

Chang, Ji Suk; Santhanam, Ramasamy; Trotta, Rossana; Neviani, Paolo; Eiring, Anna, M; Briercheck, Edward; Ronchetti, Mattia; Roy, Denis, C; Calabretta, Bruno; Caligiuri, Michael, A; Perrotti, Danilo. 2007. High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation. Blood. Vol. 110, no. 3.

Galietta, Annamaria; Gunby, Rosalind, H; Redaelli, Sara; Stano, Paola; Carniti, Cristiana; Bachi, Angela; Tucker, Philip, W; Tartari, Carmen, J; Huang, Ching-Jung; Colombo, Emanuela; Pulford, Karen; Puttini, Miriam; Piazza, Rocco, G; Ruchatz, Holger; Villa, Antonello; Donella-Deana, Arianna; Marin, Oriano; Perrotti, Danilo; Gambacorti-Passerini, Carlo. 2007. NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma. Blood. Vol. 110, no. 7.

Koschmieder, Steffen; D'Alo, Francesco; Radomska, Hanna; Schoneich, Christine; Chang, Ji Suk; Konopleva, Marina; Kobayashi, Susumu; Levantini, Elena; Suh, Nanjoo; Di Ruscio, Annalisa; Voso, Maria Teresa; Watt, Julie, C; Santhanam, Ramasamy; Sargin, Bulent; Kantarjian, Hagop; Andreeff, Michael; Sporn, Michael, B; Perrotti, Danilo; Berdel, Wolfgang, E; Muller-Tidow, Carsten; et al. 2007. CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood. Vol. 110, no. 10.

Liu, Shujun; Klisovic, Rebecca, B; Vukosavljevic, Tamara; Yu, Jianhua; Paschka, Peter; Huynh, Lenguyen; Pang, Jiuxia; Neviani, Paolo; Liu, Zhongfa; Blum, William; Chan, Kenneth, K; Perrotti, Danilo; Marcucci, Guido. 2007. Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells. The Journal of pharmacology and experimental therapeutics. Vol. 321, no. 3.

Liu, Zhongfa; Liu, Shujun; Xie, Zhiliang; Blum, William; Perrotti, Danilo; Paschka, Peter; Klisovic, Rebecca; Byrd, John; Chan, Kenneth, K; Marcucci, Guido. 2007. Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method. Nucleic acids research. Vol. 35, no. 5.

Perrotti, Danilo; Neviani, Paolo. 2007. From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way. Clinical cancer research : an official journal of the American Association for Cancer Research. Vol. 13, no. 6.

Thomas, Emily, K; Cancelas, Jose, A; Chae, Hee-Don; Cox, Adrienne, D; Keller, Patricia, J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian, J; Setchell, Kenneth D, R; Zheng, Yi; Harris, Chad, E; Williams, David A. 2007. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer cell. Vol. 12, no. 5.

Trotta R, Ciarlariello D, Dal Col J, Allard J 2nd, Neviani P, Santhanam R, Mao H, Becknell B, Yu J, Ferketich AK, Thomas B, Modi A, Blaser BW, Perrotti D, Caligiuri MA. 2007. The PP2A inhibitor SET regulates natural killer cell IFN-gamma production. The Journal of Experimental Medicine. Vol. 204, no. 10. (October).

Liu Q; Zhao X; Frissora F; Ma Y; Santhanam R; Jarjoura D; Lehman A; Perrotti D; Chen CS; Dalton JT; Muthusamy N; Byrd JC. 2008. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood. Vol. 111, no. 1. (January 1): 275.

Eiring AM; Neviani P; Santhanam R; Oaks JJ; Chang JS; Notari M; Willis W; Gambacorti-Passerini C; Volinia S; Marcucci G; Caligiuri MA; Leone GW; Perrotti D. 2008. Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. Blood. Vol. 111, no. 2. (January 15): 816.

Liu S; Liu Z; Xie Z; Pang J; Yu J; Lehmann E; Huynh L; Vukosavljevic T; Takeki M; Klisovic RB; Baiocchi RA; Blum W; Porcu P; Garzon R; Byrd JC; Perrotti D; Caligiuri MA; Chan KK; Wu LC; Marcucci G. 2008. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood. Vol. 111, no. 4. (February 15): 2364.

Perrotti D; Neviani P. 2008. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer Metastasis Reviews. Vol. 27, no. 2. (June 1): 159.

Trotta R, Col JD, Yu J, Ciarlariello D, Thomas B, Zhang X, Allard J 2nd, Wei M, Mao H, Byrd JC, Perrotti D, Caligiuri MA. 2008. TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells. Journal Of Immunology (Baltimore, Md.: 1950). Vol. 181, no. 6. (September 15): 3784-92.

Cross NC, Daley GQ, Green AR, Hughes TP, Jamieson C, Manley P, Mughal T, Perrotti D, Radich J, Skoda R, Soverini S, Vainchenker W, Verstovsek S, Villeval JL, Goldman JM. 2008. BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features. Leukemia. Vol. 22, no. 11. (November): 1975-89.

Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM. 2009. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. Vol. 114, no. 7: 1374-82.

Benson DM Jr, Yu J, Becknell B, Wei M, Freud AG, Ferketich AK, Trotta R, Perrotti D, Briesewitz R, Caligiuri MA. 2009. Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells. Blood. Vol. 113, no. 12. (March): 2706-14.

Samanta AK, Chakraborty SN, Wang Y, Kantarjian H, Sun X, Hood J, Perrotti D, Arlinghaus RB. 2009. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. Vol. 28, no. 14. (April): 1669-81.

Liu Z, Liu S, Xie Z, Pavlovicz R, Wu J, Chen P, Aimiuwu J, Pang J, Bhasin D, Neviani P, Fuchs J, Plass C, Li PK, Li C, Huang T, Wu LC, Rush L, Perrotti D, Marcucci G, Chan KK. 2009. Modulation of DNA methylation by a sesquiterpene lactone parthenolide. Journal of pharmacology and experimental therapeutics. Vol. 329, no. 2. (May): 505-14.

Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G. 2009. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood. Vol. 113, no. 25. (June): 6411-8.

Goldman J, Green T, Holyoake T, Jamieson C, Pellicano, Perrotti D, Skoda R, Vannucchi AM. 2009. Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. Leukemia. Vol. 23, no. 10. (October): 1708-15.

Positions

1985 - 1990

Pre-graduating training, University of Rome La Sapienza, Experimental Medicine, Department of Human Biopathology. Rome, Italy.

1985 - 1990

Pre-graduating training, Regina Elena Cancer Institute, Molecular Oncogenesis Lab. Rome, Italy.

1990 - 1991

Research Assistant, Regina Elena Cancer Institute, Molecular Oncogenesis Lab. Rome, Italy.

1992	Physician Officer, Italian Military Air Force Academy.

1992	Visiting Scientist, International Institute of Genetic and Biophysics. Rome, Italy.

1993 - 1997

Postdoctoral Researcher, Thomas Jefferson University, Kimmel Cancer Institute. Philadelphia, PA, United States.

1993 - 1997

Ph.D. Student in Biotechnology, Regina Elena Cancer Institute. Rome, Italy.

1998 - 2002

Research Instructor, Thomas Jefferson University, Kimmel Cancer Institute. Philadelphia, PA, United States.

2002 - 2003

Research Assistant Professor, Thomas Jefferson University, Kimmel Cancer Institute. Philadelphia, PA, United States.

2003 - 2008

Assistant Professor (tenure-track), The Ohio State University, College of Medicine, Human Cancer Genetics Program, Dept. Molecular Virology, Immunology and Medical Genetics. Columbus, OH, United States.

2003 - present

Member, Comprehensive Cancer Center, The Ohio State University, College of Medicine. Columbus, OH, United States.