OSU:pro
Dr Jianrong Li
233 Parker Food Science and Technology Building
2015 Fyffe Road
Columbus, OH 43210
Phone: (614) 688-5728
Fax: (614) 292-0218
Email: li.926
URL: http://fst.osu.edu/li/default.htm
Current OSU Appointment
Assistant Professor, Food Science & Technology
Degrees
| 1997 | D.V.M., Zhejiang University, Veterinary Medicine |
| 1999 | M.S., Zhejiang University, Veterinary Virology and Immunology |
| 2002 | Ph.D., Zhejiang University, Molecular Virology and Immunology |
Editorial Activities
Journal Ad Hoc Reviewer
| 2009 | Journal of Global Infectious Disease. (Article) |
| 2008 | Journal of Food Protection. (Article) |
| 2007 | virus research. (Article) |
| 2007 | Nucleic Acids Research. (Article) |
| 2005 | Vaccine. (Article) |
Fellowship, Internship or Residency
| 02/02 - 07/04 | Post-doctoral Research Fellow, Virology, University of Massachusetts, Worcester, MA, United States. |
| 07/04 - 05/08 | Post-doctoral Research Fellow, Virology, Harvard Medical School, Boston, MA, United States. |
Memberships
| 2002 - present | National Member. American Society for Virology, Toledo, OH, USA |
| 2005 - present | National Member. American Society for Microbiology, Washington, D.C., Washington, D.C., USA |
| 2006 - present | National Member. American Association for the Advancement of Science, AAAS, Washington, DC, Washington, DC, USA |
| 2007 - present | Honorary Member. Sigma Xi, Research Triangle Park, NC, USA |
| 2008 - present | Member. Public Health OSU Preparedness for Infectious Diseases (PHPID), Columbus, OH, USA |
| 2009 - present | Active Member. OSU Center for RNA Biology, Columbus, OH, USA |
Peer Reviewed Journal Articles
Jianrong Li, Yaowei Huang, Songshu Meng, Xueya Liang, Ronghui Xie, Lian Yu. 2001. Cloning and phylogenetic analysis of interleukin-2 gene in Xiaoshan chicken, a Chinese local chicken breed. Acta Biochimica et Biophysica Sinica.. Vol. 33, no. 6: 713-718. (IF: 0.8)
Yaowei Huang, Lian Yu, Hongwei Ding, Jianrong Li, Kunhua Song. 2001. Amplification and cloning by long RT-PCR of full-length genome of larger segment of chicken infectious bursal disease virus. Acta Biochimica et Biophysica Sinica.. Vol. 33, no. 3: 355-359. (IF: 0.8)
Lian Yu, Jianrong Li, Yaowei Huang, Ruitang Deng. 2001. Molecular characteristics of full-length of genomic segment A of three infectious bursal disease viruses in China: two attenuated strains and a field virulent strain. Avian Disease. Vol. 45, no. 4. (October): 862-874. (IF: 1.2)
Yaowei Huang, Long Li, Jianrong Li, Lian Yu. 2003. Rapid construction of infectious clones of infectious bursal disease virus. Acta Biochimica et Biophysica Sinica.. Vol. 35, no. 4. (April): 338-344. (IF: 0.8)
Jianrong Li*, Yaowei Huang, Xueya Liang, Mijia Lu, Long Li, Lian Yu, Ruitang Deng. 2003. Plasmid DNA encoding antigens of infectious bursal disease viruses induced protective immune responses in chickens: factors influencing efficacy. Virus Research. Vol. 98, no. 1. (December): 63-74. http://www.sciencedirect.com/science/journal/01681702. (IF: 2.8)
Zhiyu Wang, Anne M. Mirza, Jianrong Li, Paul J. Mahon, Ronald M. Iorio. 2004. An oligosaccharide at the C-terminus of the F-specific domain in the stalk of the human parainfluenza virus 3 hemagglutinin?neuraminidase modulates fusion. Virus Research. Vol. 99, no. 2. (February): 177-185. http://www.sciencedirect.com/science/journal/01681702. (IF: 2.8)
Jianrong Li, Quinlan Edward, Anne M. Mirza, Ronald M. Iorio. 2004. Mutated form of the Newcastle disease virus hemagglutinin-neuraminidase interact with the homologous fusion protein despite deficiencies in both receptor-recognition and fusion promotion. Journal of Virology. Vol. 78, no. 10. (May): 5299-5310. (IF: 5.4)
Jianrong Li, Vanessa R. Melanson, Anne M. Mirza, Ronald M. Iorio. 2005. Decreased dependence on receptor recognition for the fusion promotion activity of L289A-mutated Newcastle disease virus fusion protein correlates with a monoclonal antibody-detected conformational change. Journal of Virology. Vol. 79, no. 2. (January): 1180-1190.
Judith G. Alamares, Jianrong Li, Ronald M. Iorio. 2005. Monoclonal antibody routinely used to identify avirulent strains of Newcastle disease virus binds to an epitope at the carboxy terminus of the hemagglutinin-neuraminidase protein and recognizes individual mesogenic and velogenic strains. Journal of Clinical Microbiology. Vol. 43, no. 8. (August): 4229-4233. http://intl-jcm.asm.org. (IF: 3.7)
Jianrong Li, Errin C. Fontaine-Rodriguez, Sean P. J. Whelan. 2005. Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity. Journal of Virology. Vol. 79, no. 21. (November): 13373-13384. (IF: 5.4)
Jianrong Li, Jennifer Wang, Sean P. J. Whelan. 2006. A unique strategy for mRNA cap methylation used by vesicular stomatitis virus. Proceedings of the National Academy of Sciences, USA.. Vol. 103, no. 22. (May): 8493-8498. (IF: 10.5)
Long Li, Weihuan Fang, Jianrong Li, Li Fang, Yaowei Huang, Lian Yu. 2006. Oral DNA vaccination with the polyprotein gene of infectious bursal disease virus (IBDV) delivered by attenuated Salmonella elicits protective immune responses in chickens. Vaccine. Vol. 24, no. 33. (August): 5919-5927. http://www.sciencedirect.com/science/journal/0264410X. (IF: 3.4)
Yongwei Wei, Jianrong Li, Jiangtao Zheng, Hong Xu, Long Li, Lian Yu. 2006. Genetic reassortment of infectious bursal disease virus in nature. Biochemical and Biophysical Research Communications.. Vol. 350, no. 2. (November): 277-287. http://www.sciencedirect.com/science/journal/0006291X. (IF: 2.8)
Jianrong Li*, John S. Chorba*, Sean P. J. Whelan. 2007. Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. Journal of Virology. Vol. 81, no. 8. (April): 4104-4115. (IF: 5.4)
Jianrong Li*, Amal Rahmeh*, Marco Morelli, Sean P. J. Whelan. 2008. A conserved motif in large RNA dependent RNA polymerase of non-segmented negative-sense RNA viruses essential for mRNA cap formation. Journal of Virology. Vol. 82, no. 2. (January): 775-784. (IF: 5.7)
Jianrong Li*, Amal Rahmeh, Vesna Brasic, Sean P. J. Whelan*. 2009. Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis. Journal of Virology. Vol. 4, no. 83. (February): 1930-1940. (IF: 5.7)
Amal Rahmeh, Jianrong Li, Philip J. Kranzusch, and Sean P.J. Whelan. Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein. Journal of Virology. (IF: 5.7) (In press)
Positions
| 2002 - 2004 | Postdoctoral research fellow, University of Massachusetts, School of Medicine, Molecular Genetics and Microbiology. Worcester, MA, United States. |
| 2004 - 2008 | Post-doctoral Research Fellow, Harvard Medical School, Harvard Medical School, Microbiology and Molecular Genetics. Boston, MA, United States. |
| 2008 - present | Member, The Ohio State University, OSU Health Preparedness for Infectious Diseases (PHPID). Columbus, OH, United States. |
| 2008 - present | Assistant Professor, The Ohio State University, Food, Agricultural and Environmental Sciences, Food Science and Technology. Columbus, OH, United States. |
| 2008 - present | Assistant Professor, The Ohio State University, College of Public Health, Division of Environmental Health Sciences. Columbus, OH, United States. |
| 2008 - present | Principal Investigator, The Ohio State University, OSU Center for RNA Biology. Columbus, OH, United States. |
Potential Publications Under Review
Jianrong Li, Amal Rahmeh, Vesna Brusic and Sean P. J. Whelan. June 15, 2009. Conserved region V of the large polymerase protein of vesicular stomatitis virus plays a key role in mRNA cap formation, polyadenylation and RNA replication. Journal of Virology. [Peer Reviewed] (First submission)
Mike C. Wolf, Alexander N. Freiberg, Tinghu Zhang, Zeynep Akyol-Ataman, Jianrong Li, Patrick W. Hong, Hector C. Aguilar, Andrew Grock, Anna N. Honko, Joshua Johnson, Matteo Porotto, Robert Damoiseaux, John Miller, Steven Chantasirivisal, et al.,. August 20, 2009. A novel, potent broad-spectrum antiviral targeting entry of enveloped viruses. Proceedings of the National Academy of Sciences, USA. [Peer Reviewed] (First submission)
Claire Herbert, Jianrong Li*. September, 2009. Evidence that noroviruses are internalized via surface of vegetables and fruits. Applied and Environmental Microbiology. (First submission)
Xiaodong Zhang, Jianrong Li*. September, 2009. Identification of an RNA binding site in methyltransferase domain of large polymerase protein in vesicular stomatitis virus. Journal of Virology. [Peer Reviewed] (First submission)
Yuanmei Ma, Jianrong Li*. September, 2009. Vesicular Stomatitis virus expressing human norovirus virus-like particles: a novel vaccine candidate. Journal of Virology. [Peer Reviewed] (First submission)
Presentations
Invited Presentations
Local
Dr Jianrong Li, Seminar Presenter. 2004. Paramyxovirus entry: receptor interaction and membrane fusion. Presented at Department of Microbiology and Molecular Genetics, Harvard Medical School., to Department of Microbiology and Molecular Genetics, Harvard Medical School. Harvard Medical School. Boston, MA, USA. (April)
Dr Jianrong Li, Seminar Presenter. 2007. Messenger RNA processing in non-segmented negative-strand RNA viruses: a potential anti-viral target. Presented at Departmental seminar speaker, to Department of Food Science and Technology. Columbus, OH, USA. (October)
Dr Jianrong Li, Seminar Presenter. 2007. Messenger RNA modification in vesicular stomatitis virus. Presented at University of North Carolina, to Department of Biological Sciences, University of North Carolina. Wilmington, NC, USA. (December)
Dr Jianrong Li, Seminar Presenter. 2008. A conserved motif within the large polymerase protein of vesicular stomatitis virus that is essential for messenger RNA cap addition. Presented at 27th annual meeting of the American Society for Virology, to American Society for Virology,. Cornell University. Ithaca, NY, USA. (July) [Peer Reviewed]
Dr Jianrong Li, Seminar Presenter. 2009. Messenger RNA processing in non-segmented negative-strand RNA viruses. Presented at Seminar series in OSU College of Public Health, to OSU College of Public Health. Columbus, OH, USA. (March)
National
Dr Jianrong Li, Seminar Presenter. 2007. Messenger RNA modification in non-segmented negative-strand RNA viruses. Presented at The University of Georgia, to College of Veterinary Medicine, The University of Georgia. Athens, GA, USA. (December)
International
Dr Jianrong Li, Seminar Presenter. 2005. Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity. Presented at 24th annual meeting for American Society for Virology, to American Society for Virology. The Pennsylvania State University. College Park, PA, USA. (June) [Peer Reviewed]
Dr Jianrong Li, Seminar Presenter. 2006. Two methyltransferases use a single SAM-binding site in vesicular stomatitis virus large polymerase protein. Presented at 13th International Conference on Negative Strand Viruses, to International Conference on Negative Strand Viruses. Hospederia de Fonseca, Salamanca, Spain. Salamanca, Salamanca, Spain. (June) [Peer Reviewed]
Dr Jianrong Li, Seminar Presenter. 2006. A unique mRNA cap methyltransferase employed by Vesicular Stomatitis Virus. Presented at 25th annual meeting of the American Society for Virology, to American Society for Virology. University of Wisconsin-Madison. Madison, WI, USA. (July) [Peer Reviewed]
Dr Jianrong Li, Seminar Presenter. 2007. Identification of amino acid residues within the large polymerase subunit of vesicular stomatitis virus that are essential for messenger RNA cap formation. Presented at 26th annual meeting of the American Society for Virology, to American Society for Virology. Oregon State University. Corvallis, Oregon, US. (June) [Peer Reviewed]
Other Presentations
Local
Dr Jianrong Li, Seminar Presenter. 2005. Identification of mRNA cap methyltransferase in vesicular stomatitis virus large polymerase protein. Presented at Departmental seminar speaker, Department of Microbiology and Molecular Genetics, Harvard Medical School., to Department of Microbiology and Molecular Genetics, Harvard Medical School. Harvard Medical School. Boston, MA, USA. (February)
Dr Jianrong Li, Seminar Presenter. 2005. An unusual mRNA cap methyltransferase of vesicular stomatitis virus. Presented at Departmental seminar speaker, Department of Microbiology and Molecular Genetics, Harvard Medical School., to Department of Microbiology and Molecular Genetics, Harvard Medical School. Harvard Medical School. Boston, MA, USA. (October)
Dr Jianrong Li, Seminar Presenter. 2006. Where is the mRNA guanylyltransferase of non-segmented negative-sense viruses? Presented at Departmental seminar speaker, Department of Microbiology and Molecular Genetics, Harvard Medical School, to Departmental seminar speaker, Department of Microbiology and Molecular Genetics, Harvard Medical School. Harvard Medical School. Boston, MA, US. (October)
Dr Jianrong Li, Seminar Presenter. 2008. Human norovirus and food safety. Presented at Public health preparedness and infectious diseases (PHPID), to OSU Public health preparedness and infectious diseases (PHPID). (November)
Dr Jianrong Li, Presenter. 2008. Novel vaccine strategy against non-cultivable foodborne viruses. Presented at The Ohio State University, to Department of Food Science and Technology. Columbus, OH, USA. (November)
State
Dr Jianrong Li, Seminar Presenter. 2005. An unusual mRNA cap methyltransferase of vesicular stomatitis virus. Presented at harvard RNA virus group meeting, to Harvard Medical School. Harvard Medical School. Boston, MA, USA. (April)
Professional Activities
Conference Participation
| 07/2005 | 24th Annual meeting. Presenter. American Society for Virology. American Society for Virology. |
| 07/2006 | 25th Annual meeting. Presenter. American Society for Virology. American Society for Virology. |
| 2007 | Presenter. The Viruses and Cells Gordon Research Conference. The Viruses and Cells Gordon Research Conference. |
| 2007 | 13th International Conference on Negative Strand Viruses. Presenter. International Conference on Negative Strand Viruses. International Conference on Negative Strand Viruses. |
| 07/2007 | 26th Annual meeting, American Society for Virology. Presenter. American Society for Virology. American Society for Virology. |
| 07/2008 | 27th Annual meeting. Presenter. American Society for Virology. American Society for Virology. |
| 07/2009 | Panel Member. Panelist. USDA The National Integrated Food Safety Initiative (NIFSI). USDA The National Integrated Food Safety Initiative (NIFSI). Washington DC, DC, USA. |
| 07/2009 | 28th Annual meeting. Presenter. American Society for Virology. American Society for Virology. |
Education
| 01/01/2005 - 01/01/2007 | Advisor for High School Student. Mentor. Harvard Medical School. Boston, MA. Key achievements: This student won US national high school student research scholarship. |
Research
| 10/01/2008 | OARDC Seeds Grant. Grant Reviewer. |
| 2009 | USDA, The National Integrated Food Safety Initiative (NIFSI). Grant Reviewer. Key achievements: Referee |
| 07/01/2009 | USDA, The National Integrated Food Safety Initiative (NIFSI). Grant Reviewer. |