OSU:pro

Current OSU Appointment

Assistant Professor, College of Pharmacy

Abstracts

Morris, Garrett M.; Huey, Ruth; Lindstrom, William; Li, Chenglong; Zhao, Yong; Hart, William E.; Belew, Richard; Sanner, Michel F.; Goodsell, David S.; Olson, Arthur J. 2004. "Recent advances in AutoDock: Search, representation and scoring." Abstract. Abstracts of Papers, 228th ACS National Meeting. ACS: Philadelphia, PA, USA. [Editor Reviewed]

Li, Chenglong. 2004. "Successful Virtual Screening for Human AICAR Transformylase Inhibitors against NCI Diversity set Using AutoDock." Abstract. Applications of Cheminformatics and Chemical Modelling to Drug Discovery. eChemInfo: San Diego, CA, USA. [Editor Reviewed]

Li, Chenglong. 2007. "Novel inhibitors of DNA methyltransferase 1." Abstract. Abstracts, 39th Central Regional Meeting of the American Chemical Society. ACS: Covington, KY, USA. [Editor Reviewed]

Park, In Hee; Li, Chenglong. 2008. "Novel ligand-induced Survivin dimer conformation via replica exchange molecular dynamics (REMD) and receptor-based reverse virtual screening." Abstract. Abstracts of Papers, 235th ACS National Meeting. ACS: New Orleans, LA, USA. [Editor Reviewed]

Cisek, Katryna K.; Li, Chenglong. 2008. "Computational Design of STAT3 Inhibitors for Targeted Anti-Cancer Therapy." Abstract. Abstracts, 40th Central Regional Meeting of the American Chemical Society. ACS: Columbus, OH, USA. [Editor Reviewed]

Kumari, Vandana; Li, Chenglong. 2008. "Molecular Dynamics Simulation of Beta-2 Adrenergic Receptor." Abstract. Abstracts, 40th Central Regional Meeting of the American Chemical Society. ACS: Columbus, OH, USA. [Editor Reviewed]

Mahasenan, Kiran V.; Li, Chenglong. 2008. "Comparative Modeling of Human Protein Arginine Methyltransferase 5 (PRMT5) and Substrate Binding Site Characterization through Molecular Docking for Target Specific Inhibitor Design." Abstract. Abstracts, 40th Central Regional Meeting of the American Chemical Society. ACS: Columbus, OH, USA. [Editor Reviewed]

Park, In-Hee; Li, Chenglong. 2008. "Novel Ligand-Induced-Fit Simulation of Survivin Via Replica Exchange Molecular Dynamics (REMD) and Receptor-Based Reverse Virtual Screening (VS)." Abstract. Abstracts, 40th Central Regional Meeting of the American Chemical Society. ACS: Columbus, OH, USA. [Editor Reviewed]

Pavlovicz, Ryan; Li, Chenglong. 2008. "Modeling Nicotinic Acetylcholine Receptors for Computational Drug Design." Abstract. Abstracts, 40th Central Regional Meeting of the American Chemical Society. ACS: Columbus, OH, USA. [Editor Reviewed]

Fuchs, James R.; Etter, Jonathan P.; Li, Pui-Kai; Abdelhamid, Dalia; Regan, Nicholas; Bhasin, Deepak; Pandit, Bulbul; Li, Chenglong; Cisek, Katryna; Lin, Jiayuh; Cen, Ling; Hutzen, Brian. 2008. "Synthesis and antiproliferative activity of curcumin analogs." Abstract. Abstracts of Papers, 236th ACS National Meeting. ACS: Philadelphia, PA, USA. [Editor Reviewed]

Li, Chenglong; Li, Huameng. 2008. "Simulating molecular recognition through simultaneous multiple molecule docking." Abstract. Abstracts of Papers, 236th ACS National Meeting. ACS: Philadelphia, PA, USA. [Editor Reviewed]

Biographical Narrative

Dr. Chenglong Li obtained his B. Sc. in Chemistry and M. Sc. in Physical Chemistry from Beijing University in 1985 and 1988, respectively. He worked at the Institute of Biophysics at the Chinese Academy of Sciences. He came to the United States and obtained his Ph.D. in Biophysics at Cornell University, New York in 2000. He spent five years in San Diego, California, working as a postdoc in Structural Biology at the Burnham Institute for Medical Research (2000-2002) and research associate in Computational Chemistry at the Scripps Research Institute (2002-2005). Starting August 1, 2005, he moved to Columbus, Ohio as a tenure-track assistant professor in the Division of Medicinal Chemistry and Pharmacognosy at the College of Pharmacy, the Ohio State University.
Dr. Li's research interests focus on molecular recognition, with a strong application to structure-based computer-aided drug design. He combines molecular modeling, X-ray crystallography and thermodynamic measurements to explore molecular interactions, especially protein-ligand interactions, at both atomic and electronic levels. His current working projects includes both computational method developement and drug design: 1) development of a novel multi-fragment docking strategy; 2) design and discovery of STAT3 SH2 domain binders for targeted cancer therapy; 3) design and discovery of UGPase inhibitors for anti-Leishmaniasis; 4) strucutural, mechanistic and inhibition studies of novel N-glycosidases RCL and BlsM.

Bulletins and Technical Reports

Li, Chenglong. 2004. Successful Virtual Screening for Human AICAR Transformylase Inhibitors against NCI Diversity set Using AutoDock. San Diego.

Ohio State University. 2008. Synthetic Molecules Could Add Spice To Fight Against Cancer. Columbus, Ohio. (Report No. Science Daily Aug. 18, 2008)

Ohio Supercomputing Cneter. 2008. Headline: Finding treatments for neurological diseases. Columbus. (Report No. 2008 Annual Report)

Degrees

1985	B.S., Peking University, Chemistry

1988	M.S., Peking University, Physical Chemistry

2000	Ph.D., Cornell University, Biophysics

2002	Postdoctoral, Burnham Institute for Medical Research, Structural biology

2005	Postdoctoral, The Scripps Research Institute, Computational Chemistry

Editor Reviewed Journal Articles

Morris, Garrett M.; Huey, Ruth; Lindstrom, Willam; Li, Chenlong; Zhao, Yong; Hart, William E.; Belew, Richard; Sanner, Michel F.; Goodsell, David S.; Olson, Arthur J. 2004. Recent advances in autodock: Search, representation and scoring. Abstracts of Papers American Chemical Society. Vol. 228, no. Part 1.

Xu, Lan; Li, Chenglong; Olson, Arthur J.; Wilson, Ian A. 2004. Structure-based inhibitor design for a cancer target in de novo purine biosynthesis pathway. Molecular & Cellular Proteomics. Vol. 3, no. 10, Suppl. S. (IF: 9.425)

Fang, Lanyan; Zhang, Guisheng; Li, Chenglong; Zheng, Guisheng; Zhu, Lizhi; Xiao, Jim J.; Szakacs, Gergely; Chan, Kenneth K.; Wang, George P.; Sun, Duxin. 2006. New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 47.

Bhasin, Deepak; Cisek, Katryna; Pandharkar, Trupti; Pahdit, Bulbul; Li, Chenglong; Lin, Jiayuh; Li, Pui-Kai. 2007. Small molecule inhibitors of Stat3 dimerization for prostate cancer. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 48.

Liu, Zhongfa; Liu, Shujun; Xie, Zhiliang; Li, Chenglong; Aimiuwu, Josephine; Chen, Ping; Pang, Jiuxia; Marcucci, Guido; Chan, Kenneth K. 2007. Nf-kappab inhibitor parthenolide mediates Dna demethylation and histone acetylation in leukemia cells. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 48.

Hsu, Pei-Yin; Liu, Hsiao-Sheng; Li, Chenglong; Qin, Huaxia; Lai, Ming-Derg; Cheng, Hong-Lin; Tzai, Tzong-Shin; Cheng, Alfred S. L.; Davuluri, Ramana V.; Yan, Pearlly; Huang, Tim H. -M.; Chow, Nan-Haw. 2008. Heterologous interaction facilitates nuclear translocalization of membranous Ron to modulate stress-responsive transcription. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 49.

Hutzen, Brian; Cen, Ling; Friedman, Lauren; Sobo, Matthew; Ball, Sarah; Li, Pui-Kai; Li, Chenglong; Fuchs, James; Bhasin, Deepak; Pandit, Bulbul; Shibata, Hiroyuki; Iwabuchi, Yoshiharu; Lin, Jiayuh. 2008. New curcumin analogues with enhanced growth suppressive activity in cancer cells. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 49.

Editorial Activities

Ad Hoc Reviewer

Journal of Medicinal Chemistry. (Article)

Journal of the American Chemistry Society.

Journal of Computational Chemistry.

Proteins: Structure, Function, and Bioinformatics.

Bioorganic and Medicinal Chemistry Letters.

Journal of Computer-Aided Molecular Design.

Journal of Natural Products.

Honors

2001 - 2004

The Department of Defense Breast Cancer Fellowship. Department of Defense. ($150,000.00) Subject: Structural biology

Inventions and Patents

Li, P.-K.; Li, C.; Fuchs, J. R.; Lin, J., Inventor, Patent filing 2008 (patent status unknown). Novel anti-cancer curcumin analogs. . Ohio State University. 25% Authorship: Computational design and modeling.

Languages

Chinese: Mandarin (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)

English: Standard (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)

Memberships

1994 - present

Member. American Chemical Society. computers in chemistry, physical chemistry, biochemistry, medicinal chemistry

1995 - present

Member. American Crystallographic Association. macromolecules

2005 - present

Member. American Association for Cancer Research

Moving Image

Inhee Park and Chenglong Li. Director. Multi-molecular "dancing" on protein surface [quicktime movie]. [dir.] Chenglong Li. (Forthcoming)

Papers in Proceedings

Xu, Lan; Li, Chenglong; Olson, Arthur J.; Wilson, Ian A. 2004. "Structure-based inhibitor design for a cancer target in de novo purine biosynthesis pathway." In: Molecular & Cellular Proteomics. October3 S321. Human Proteome Org, Beijing, China. [Peer Reviewed]

Hsu, Pei-Yin; Liu, Hsiao-Sheng; Li, Chenglong; Qin, Huaxia; Lai, Ming-Derg; Cheng, Hong-Lin; Tzai, Tzong-Shin; Cheng, Alfred S. L.; Davuluri, Ramana V.; Yan, Pearlly; Huang, Tim H. -M.; Chow, Nan-Haw. 2008. "Heterologous interaction facilitates nuclear translocalization of membranous RON to modulate stress-responsive transcription." In: Proceedings of the American Association for Cancer Research Annual Meeting. April49 526. Amer Assoc Canc Res, San Diego, CA, USA. [Peer Reviewed]

Hutzen, Brian; Cen, Ling; Friedman, Lauren; Sobo, Matthew; Ball, Sarah; Li, Pui-Kai; Li, Chenglong; Fuchs, James; Bhasin, Deepak; Pandit, Bulbul; Shibata, Hiroyuki; Iwabuchi, Yoshiharu; Lin, Jiayuh. 2008. "New curcumin analogues with enhanced growth suppressive activity in cancer cells." In: Proceedings of the American Association for Cancer Research Annual Meeting. April49 291. Amer Assoc Canc Res, San Diego, CA, USA. [Peer Reviewed]

Peer Reviewed Journal Articles

Ma, Chiming; Li, Chenglong. 1989. Interaction between polyvinylpyrrolidone and sodium dodecyl sulfate at solid/liquid interface. Journal of Colloid and Interface Science. Vol. 131: 485-492. (IF: 2.309)

Ma, Chiming; Li, Chenglong. 1990. Stability of dispersions of iron oxide in mixed solutions of polyvinylpyrrolidone and sodium alkyl sulfate. Colloids and Surfaces. Vol. 47: 117-123. (IF: 2.109)

Li, Chenglong; Kappock, T. Joseph; Stubbe, JoAnne; Weaver, Todd M.; Ealick, Steven E. 1999. X-ray crystal structure of aminoimidazole ribonucleotide synthetase (purm), from the Escherichia coli purine biosynthetic pathway at 2.5 Ang resolution. Structure (London). Vol. 7, no. 9. (IF: 5.231)

Mueller, E. J.; Oh, S.; Kavalerchik, E.; Kappock, T. J.; Meyer, E.; Li, C.; Ealick, S. E. and Stubbe, J. 1999. Investigation of the ATP Binding Site of Escherichia coli Aminoimidazole Ribonucleotide Synthetase Using Affinity Labeling and Site-Directed Mutagenesis. Biochemistry. Vol. 38: 9831-9839. (IF: 3.368)

Ely, Kathryn R.; Li, Chenglong; Cheng, Genhong; He, Jeannie; Satterthwait, Arnold C.; Cabezas, Edelmira. 2001. Molecular recognition between TRAF3 and TANK in downstream TNF signaling pathways. Journal of Leukocyte Biology Supplement. Vol. Sup.: 21-22. (IF: 4.128)

Ely, Kathryn, R; Li, Chenglong. 2002. Structurally adaptive hot spots at a protein interaction interface on TRAF3. Journal of molecular recognition : JMR. Vol. 15, no. 5. (IF: 3.767)

Li, Chenglong; Ni, Chao-Zhou; Havert, Marnie, L; Cabezas, Edelmira; He, Jeannie; Kaiser, Donald; Reed, John, C; Satterthwait, Arnold, C; Cheng, Genhong; Ely, Kathryn R. 2002. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. Structure (London, England : 1993). Vol. 10, no. 3. (IF: 5.231)

Bennett, Eric, M; Li, Chenglong; Allan, Paula, W; Parker, William, B; Ealick, Steven E. 2003. Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. The Journal of biological chemistry. Vol. 278, no. 47. (IF: 5.581)

Ely, Kathryn R.; Li, Chenglong; Norris, Paula S.; Ni, Chao-Zhou; Satterthwait, Arnold C.; Reed, John C.; Ware, Carl F. 2003. Distinct recognition motifs in Ltbetar vs Cd40 for Traf3 signaling. European Cytokine Network. Vol. 14, no. Supplement 3. (IF: 2.064)

Li, Chenglong; Norris, Paula, S; Ni, Chao-Zhou; Havert, Marnie, L; Chiong, Elizabeth, M; Tran, Bonnie, R; Cabezas, Edelmira; Reed, John, C; Satterthwait, Arnold, C; Ware, Carl, F; Ely, Kathryn R. 2003. Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. The Journal of biological chemistry. Vol. 278, no. 50. (IF: 5.581)

Matsuzawa, Shu-ichi; Li, Chenglong; Ni, Chao-Zhou; Takayama, Shinichi; Reed, John C.; Ely, Kathryn R. 2003. Structural analysis of Siah1 and its interactions with Siah-interacting protein (sip). Journal of Biological Chemistry. Vol. 278, no. 3.

Ni, Chao-Zhou; Li, Chenglong; Wu, Joe, C; Spada, Alfred, P; Ely, Kathryn R. 2003. Conformational restrictions in the active site of unliganded human caspase-3. Journal of molecular recognition : JMR. Vol. 16, no. 3. (IF: 3.767)

Zhang, Yan; Desharnais, Joel; Marsilje, Thomas H.; Li, Chenglong; Hedrick, Michael P.; Gooljarsingh, Lata T.; Tavassoli, Ali; Benkovic, Stephen J.; Olson, Arthur J.; Boger, Dale L.; Wilson, Ian A. 2003. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human Gar Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. Vol. 42, no. 20.

Jiang, Zhengfan; Li, Chenglong; Shamel, Louis; Olson, Arthur; Beutler, Bruce. 2004. Pococurante (poc): An Enu-induced missense mutation of Myd88 with selective effects on Tlr signal transduction. Blood. Vol. 104, no. 11, Part 1. (IF: 10.896)

Li, Chenglong; Xu, Lan; Wolan, Dennis W.; Wilson, Ian A.; Olson, Arthur J. 2004. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the Nci diversity set by use of Autodock to identify novel nonfolate inhibitors. Journal of Medicinal Chemistry. Vol. 47, no. 27. (IF: 4.895)

Xu, Lan; Li, Chenglong; Olson, Arthur J.; Wilson, Ian A. 2004. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. Journal of Biological Chemistry. Vol. 279, no. 48. (IF: 5.581)

Briknarova, Klara; Nasertorabi, Fariborz; Havert, Marnie L.; Eggleston, Ericka; Hoyt, David W.; Li, Chenglong; Olson, Arthur J.; Vuori, Kristiina; Ely, Kathryn R. 2005. The serine-rich domain from Crk-associated substrate (p130(cas)) is a four-helix bundle. Journal of Biological Chemistry. Vol. 280, no. 23. (IF: 5.581)

Santelli, Eugenio; Leone, Marilisa; Li, Chenlong; Fukushima, Toru; Preece, Nicholas E.; Olson, Arthur J.; Ely, Kathryn R.; Reed, John C.; Pellecchia, Maurizio; Liddington, Robert C.; Matsuzawa, Shu-ichi. 2005. Structural analysis of Siah1-siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. Journal of Biological Chemistry. Vol. 280, no. 40. (IF: 5.581)

Wu, ShuangDing; Xie, Ping; Welsh, Kate; Li, Chenglong; Ni, Chao-Zhou; Zhu, Xiuwen; Reed, John C.; Satterthwait, Arnold C.; Bishop, Gail A.; Ely, Kathryn R. 2005. Lmp1 protein from the Epstein-barr virus is a structural Cd40 decoy in B lymphocytes for binding to Traf3. Journal of Biological Chemistry. Vol. 280, no. 39. (IF: 5.581)

Fang, Lanyan; Zhang, Guisheng; Li, Chenglong; Zheng, Xincheng; Zhu, Lizhi; Xiao, Jim, J; Szakacs, Gergely; Nadas, Janos; Chan, Kenneth, K; Wang, Peng George; Sun, Duxin. 2006. Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance. Journal of medicinal chemistry. Vol. 49, no. 3. (IF: 4.895)

Jiang, Zhengfan; Georgel, Philippe; Li, Chenglong; Choe, Jungwoo; Crozat, Karine; Rutschmann, Sophie; Du, Xin; Bigby, Tim; Mudd, Suzanne; Sovath, Sosathya; Wilson, Ian, A; Olson, Arthur; Beutler, Bruce. 2006. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 29. (IF: 9.598)

Li, Pui-Kai; Pandit, Bulbul; Sackett, Dan, L; Hu, Zhigen; Zink, Jennifer; Zhi, Jiandong; Freeman, Dena; Robey, Robert, W; Werbovetz, Karl; Lewis, Andrew; Li, Chenglong. 2006. A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities. Molecular cancer therapeutics. Vol. 5, no. 2. (IF: 4.800)

Pandit, Bulbul; Sun, Yanjun; Chen, Ping; Sackett, Dan, L; Hu, Zhigen; Rich, Wendy; Li, Chenglong; Lewis, Andrew; Schaefer, Kevin; Li, Pui-Kai. 2006. Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416. Bioorganic & medicinal chemistry. Vol. 14, no. 19. (IF: 2.662)

Shiau, Chung-Wai; Huang, Jui-Wen; Wang, Da-Sheng; Weng, Jing-Ru; Yang, Chih-Cheng; Lin, Chia-Hui; Li, Chenglong; Chen, Ching-Shih. 2006. alpha-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. The Journal of biological chemistry. Vol. 281, no. 17. (IF: 5.581)

George, Tesmol, G; Endeshaw, Molla, M; Morgan, Rachel, E; Mahasenan, Kiran, V; Delfin, Dawn, A; Mukherjee, Mitali, S; Yakovich, Adam, J; Fotie, Jean; Li, Chenglong; Werbovetz, Karl A. 2007. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Bioorganic & medicinal chemistry. Vol. 15, no. 18. (IF: 2.662)

Werbovetz, Karl; Endeshaw, Molla; Morgan, Rachel; Li, Chenglong; Diraviyam, Karthikeyan; Sept, David. 2007. Parasite tubulin as a drug target. American Journal of Tropical Medicine and Hygiene. Vol. 77, no. 5, Suppl. S. (IF: 2.183)

Xu, Lan; Chong, Youhoon; Hwang, Inkyu; D'Onofrio, Anthony; Amore, Kristen; Beardsley, G Peter; Li, Chenglong; Olson, Arthur, J; Boger, Dale, L; Wilson, Ian A. 2007. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of biological chemistry. Vol. 282, no. 17. (IF: 5.581)

Bhasin, Deepak; Cisek, Katryna; Pandharkar, Trupti; Regan, Nicholas; Li, Chenglong; Pandit, Bulbul; Lin, Jiayuh; Li, Pui-Kai. 2008. Design, synthesis, and studies of small molecule STAT3 inhibitors. Bioorganic & medicinal chemistry letters. Vol. 18, no. 1. (IF: 2.604)

Fuh B., Sobo M., Cen L, Sobo M., Josiah D., Hutzen B., Cisek K., Bhasin D., Regan N., Chan C, Caldas, H., Li C., Li P., and Lin J. LLL-3 inhibits STAT3 activity, suppresses glioblastoma multiforme cell growth and prolongs survival in a mouse glioblastoma multiforme model. British Journal of Cancer. (IF: 4.635) (Forthcoming)

González-Cestari, T. F., Henderson, B. J., Pavlovicz, R. E., McKay, S. B., El-Hajj, R. A., Pulipaka, A. B., Orac, C. M., Reed, D. D., Boyd, T., Zhu, M. X., Li, C., Bergmeier, S. C. and McKay, D. B. Characterization of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors: Implications for Drug Discovery. Molecular Pharmacology. (IF: 3.622) (Forthcoming)

Nadas, J., Li, C., and Wang, P. G. Computational Structure Activity Relationship Studies on the CD1d/glycolipid/TCR Complex using AMBER and AUTODOCK. Journal of Chemical Information and Modeling. (IF: 2.986) (Forthcoming)

Patil, Popat, N; Li, Chenglong; Kumari, Vandana; Hieble, J Paul. 2008. Analysis of efficacy of chiral adrenergic agonists. Chirality. Vol. 20, no. 3-4. (IF: 2.436)

Positions

2005 - present

Assistant Professor, The Ohio State University, College of Pharmacy, Medicinal Chemistry and Pharmacognosy. Columbus, OH, United States.

2006 - present

Assistant Professor, The Ohio State University, Mathematical and Physical Sciences, The Ohio State University, Chemical Physics Program. Columbus, OH, United States.

2006 - present

Assistant Professor, The Ohio State University, Biophysics Program. Columbus, OH, United States.

2006 - present

Assistant Professor, The Ohio State University, Biochemistry Program. Columbus, OH, United States.

2007 - present

Assistant Professor, The Ohio State University, Engineering, Biomedical Engineering. Columbus, OH, United States.

Potential Publications Under Review

Liu, Z.; Xie, Z.; Liu, S.; Pavlovicz, R. E.; Wu, J.; Plass, C.; Li, P.-K.; Li, C.; Huang, T. H.-M.; Marcucci, G. And Chan, K. K. February 16, 2008. DNA Methylation Modulation by a Sesquiterpene Lactone Parthenolide. Cancer Research. [Editor Reviewed] (Revised submission)

Hsu, P.-Y., Liu, H.-S., Li, C., Qin, H., Lai, M.-D., Cheng, H.-L., Tzai, T.-S., Cheng, A. S. L., Davuluri, R. V., Yan, P. S. Huang, T. H.-M. and Chow, N.-H. April 06, 2008. Heterologous Interaction Facilitates Nuclear Translocalization of Membranous RON for Modulating Stress-responsive Transcription. Oncogene. [Peer Reviewed] (First submission)

Kumari, V. and Li, C. August 10, 2008. Comparative Docking Assessment of Glucokinase Interactions with Its Allosteric Activators. Current Chemical Genomics. [Peer Reviewed] (First submission)

Professional Activities

Research

2012	Genome Canada. Grant Reviewer.

Recordings

Chenglong Li and Barry Hardy. Lecturer. November 2004. (Structure-based virtual screening) [CD]. DouglasConnect. http://douglasconnect.com/. 2004(P). (Forthcoming)

Research Interests

My long-standing scientific interest is to understand the structure and dynamics of matter at the atomic/molecular level. Specifically, I would start with the study of molecular recognition because molecular recognition between biomolecules like proteins, DNAs, RNAs and small ligands is of central importance in biological and pharmacological processes like signal transduction, DNA transcription, enzymatic reaction and drug action. Three aspects of focus: 1) Structure-based/computer-aided drug design (SBDD/CADD); 2) Molecular docking and free energy simulation; 3) X-ray macromolecular crystallography.

1) Developed a novel multi-molecule docking methodology, particular good for fragment-based drug design.
2) Developed a novel hierarchical virtual screening methodology, considering both compound chemical diversity and similarity.
3) Design and discovery of a novel class of curcumin analogs dual-targeting STAT3 and JAK2 for anti-cancer therapy in a group effort with Drs. P.-K. Li, J. R. Fuchs and J. Lin. Patent filing is in the process.
4) Design and discovery of a novel lead compound targeting UGPase for anti-Leishmaniasis through virtual screening, in collaboration with Dr. K. Werbovetz.

1) Development of a novel multi-fragment docking strategy;
2) Design and discovery of STAT3 SH2 domain binders for targeted cancer therapy;
3) Design and discovery of UGPase inhibitors for anti-Leishmaniasis;
4) Strucutural, mechanistic and inhibition studies of novel N-glycosidases RCL and BlsM.

Undergrad., Grad. and Prof. Courses Taught

Autumn 2005. The Ohio State University, Biochemp. OSBP Faculty Colloquium 790. 1 credit hours, 10% Taught

Winter 2006. The Ohio State University, CSE. Geometric Methods in Computational Structural Biology 788. 3 credit hours, 5% Taught

Spring 2006. The Ohio State University, PHARMACY. Drug Discovery and Drug Design 735. 3 credit hours, 20% Taught

Summer 2006. The Ohio State University, MCB. Practical Macromolecular Crystallography 840. 3 credit hours, 20% Taught

Spring 2007. The Ohio State University, PHARMACY. Introduction to Medicinal Chemistry 410. 3 credit hours, 15% Taught

Spring 2007. The Ohio State University, PHARMACY. Drug Discovery and Drug Design 735. 3 credit hours, 20% Taught

Autumn 2007. The Ohio State University, Pharmacy. Concepts in Pharmacology I: Discovery of Drug Action 471. 2 credit hours, 5% Taught

Autumn 2007. The Ohio State University, PHARMACY. Advanced Medicinal Chemistry 835. 3 credit hours

Spring 2008. The Ohio State University, PHARMACY. Introduction to Medicinal Chemistry 410. 3 credit hours, 15% Taught

Spring 2008. The Ohio State University, Chem. Statistical Thermodynamics 880. 3 credit hours, 4% Taught

Summer 2008. The Ohio State University, MolBioch. Practical Macromolecular Crystallography 840. 3 credit hours, 23% Taught