Current OSU Appointment

Assistant Professor, Pulmonary/Critical Care

Chapters In Books

Khramtsov, VV and Weiner, LM. 1988. Proton exchange in stable nitroxyl radicals: pH-sensitive spin probes. In Imidazoline Nitroxides. Edited by Volodarsky, LB. Boca Raton: CRC Press. 37-80.

Dikalov S, Khramtsov V, Zimmer G. 1997. Reaction of lipoate and its derivatives with reactive oxygen species. In Lipoic Acid in Health and Disease. Edited by J. Fuchs, L. Packer. New York: Marcel Dekker, Inc. 47-66.

Khramtsov VV, Volodarsky LB. 1998. Use of imidazoline nitroxides in studies of chemical reactions: ESR measurements of concentration and reactivity of protons, thiols and nitric oxide. In Biological Magnetic Resonance, Volume 14:Spin Labeling: The Next Millennium. Edited by LJ Berliner. New York: Plenum Press. 109-180.

Berliner LJ, Khramtsov V, Fuji H, Clanton TL. 2001. Unique Applications of Spin Traps As Indicators of Oxidative Stress in Living Systems. In Bio-Assays for Oxidative Stress Status (BOSS). Edited by W.A. Pryor. Elsevier. 262-272.

Khramtsov VV. 2001. New Approaches in Spin Labeling and Spin Trapping Part One: ESR Studies of Local Chemical Environment. In Supramolecular Structure and Function 7. Edited by G.Pifat. Kluwer/Academic/Plenum Publishers. 89-106.

Khramtsov VV, Berliner LJ, Clanton TL. 2001. New Approaches in Spin Labeling and Spin Trapping Part Two: NMR Detects Free Radicals. In Supramolecular Structure and Function 7. Edited by G.Pifat. Kluwer/Academic/Plenum Publishers. 107-118.

Luri DJ, Foster MA, Youngdee W, Khramtsov VV, Grigor'ev IA. 2002. Recent progress and future prospects of free radical imaging by PEDRI. In EPR in the 21st Century. Edited by Kawamori A, Yamauchi J, Ohta H. Elsevier Science BV. 515-523.

Khramtsov, V.V. 2007. Functional EPR spectroscopy and imaging of nitroxides. In Supramolecular Structure and Function 9. Edited by Pifat-Mrzljak, G. New York, Boston, Dordrecht, London, Moscow: Kluwer Academic/Plenum. 181-208.

Degrees

1980	M.S., Novosibirsk State University, Chemical Physics

1986	Ph.D., Novosibirsk State University, Biophysics, Spectroscopy

1993	D.S., Novosibirsk State University, Chemistry, Spectroscopy

Editorial Activities

Grant Reviewer

2007	Civilian Research and Development Foundation (CRDF).

2007	Russian Foundation for Basic Research.

Honors

1987	All-Union Mendeleev Chemical Society Award.

1989	Fellowship.

1994	Gold Medal Award.

1997	Research Fellowship.

Memberships

1990 - 2007

Member. International EPR Society

1998 - 2007

Member. Society for Free Radical Biology and Medicine

2002	Member. VI International Voevodsky Conference. Organizing Committee

2003 - 2007

Member. Ohio Physiological Society

2003 - 2007

Member. Biophysical Society

Peer Reviewed Journal Articles

Gruzdev, AG, Khramtssov, VV, Weiner LM, Budker, VG. 1982. Fluorescence polarization study of the interaction of biopolimers with liposomes. FEBS Letters. Vol. 137: 227-330.

Khramtsov VV, Weiner, LM, Grigor'ev, IA, Volodarsky, LB. 1982. Proton exchange in stable nitroxyl radicals. Chem. Phys. Letters. Vol. 91: 69-72.

Grigor'ev LA, Schukin GI, Khramtsov VV, Weiner LM, Starichenko VF, Volodarsky LB. 1985. Transformation of nitroxyl radicals of 3-inidazoline-3-oxide in nitronylnitroxyl radicals. Izv, AN.SSSR, ser. khimicheskaja (Russia): 2342-2351.

Khramtsov VV, Weiner LM, Eremenko SI, Belchenko OI, Schastnev PV, Grigor'ev LA, Reznikov VA. 1985. Proton exchange in stable nitroxyl radicals of imidazoline and imidazolidine series. J. Magn. Res.. Vol. 61: 397-408.

Khramtsov VV, Weiner LM, Grigor'ev LA, Reznikov VA, Schukin GI, Volodarsky LB. 1985. The influence of protonation and deprotonation of functional groupd of nitroxyl radicals on their EPR spectra. Khimicheskaja Fizika (Russia): 637-643.

Khramtsov VV, Weiner LM, Gogolev AZ, Grigor'ev IA, Starichenko VK, Volodarsky LB. 1986. ESR and PMR studies of a new class of nitroxyl, nitronylnitroxyl and iminonitroxyl radicals. Magn. Reson. Chem.. Vol. 24: 199-207.

Khramtsov VV, Weiner LM. 1987. Kinetic parameters of proton exchange in stable nitroxyl radicals. Khimicheskaja Fizika (Russia).

Khramtsov, V.V. and Weiner, L.M. 1988. Proton transfer reactions in free Radicals. Spin pH Probes. Russian Chemical Reviews. Vol. 57, no. 9: 824-839.

Khramtsov, V, V; Panteleev, M, V; Weiner, L M. 1989. ESR study of proton transport across phospholipid vesicle membranes. Journal of biochemical and biophysical methods. Vol. 18, no. 3: 237-46.

Khramtsov, V, V; Yelinova, V, I; Weiner, L, M; Berezina, T, A; Martin, V, V; Volodarsky, L B. 1989. Quantitative determination of SH groups in low- and high-molecular-weight compounds by an electron spin resonance method. Analytical biochemistry. Vol. 182, no. 1: 58-63.

Berezina TA, Martin VV, Volodarsky LB, Khramtsov VV, Weiner LM. 1990. Synthesis of amidine derivatives of imidazoline nitroxyl radicals-new series of pH-sensitive spin probes and labels. Bioorganicheskaja Khimija (Russia). Vol. 16: 262-269.

Khramtsov, V, V; Vainer, L, M; Rar, V, A; Berezina, T, A; Martin, V, V; Volodarskii, L B. 1990. [Macromolecular spin pH-probes on the basis of human serum albumin]. Biokhimii?a? (Moscow, Russia). Vol. 55, no. 6: 1014-7.

Khramtsov VV, Yelinova VI, Goryunova TE, Weiner LM. 1991. Quantitative determinationand Reversible Modification of Sulfhydryl Groups in Low-and High-Molecular-Weight Compounds using Biradical Spin Label. Biochemistry (Moscow). Vol. 56: 1567-1577.

Khramtsov, V, V; Gorunova, T, E; Weiner, L M. 1991. Monitoring of enzymatic activity in situ by EPR. Biochemical and biophysical research communications. Vol. 179, no. 1: 520-7.

Khramtsov, V, V; Marsh, D. 1991. Measurement of the local translational diffusion rates of proteins by saturation transfer EPR spectroscopy. Biochimica et biophysica acta. Vol. 1068, no. 2: 257-60.

Balakirev M Yu, Khramtsov VV, Berezina TA, Martin VV, Volodarsky LB. 1992. The synthesis of amidine derivatives of imidazoline nitroxides-a series of pH-sensitive spin probes and labels. Synthesis. Vol. 12: 1223-1225.

Khramtsov, V, V; Marsh, D; Weiner, L; Reznikov, V A. 1992. The application of pH-sensitive spin labels to studies of surface potential and polarity of phospholipid membranes and proteins. Biochimica et biophysica acta. Vol. 1104, no. 2: 317-24.

Balakirev M Yu, Khramtsov VV. 1993. New pH-sensitive aminoxyls-application to the study of biomembrane transport processes. J. Chem. Sos. Perkin Trans. 2. Vol. 11: 2157-2160.

Khramtsov, V, V; Grigor'ev, I, A; Kiriljuk, I, A; Utepbergenov, D I. 1994. Spin trapping of nitric oxide by nitronylnitroxides: measurement of the activity of no synthase from rat cerebellum. Biochemical and biophysical research communications. Vol. 202, no. 1: 195-203.

Khramtsov VV, Woldman YaYu, Grigo'ev IA, Kiriljuk IA, Utepbergenov DI. 1995. Trapping of nitric oxide and nitric oxide synthase activity measurement by nitronylnitroxyl radicals. Magnetic Reson. in Medicine. Vol. 6: 282-284.

Slepneva, I, A; Sergeeva, S, V; Khramtsov, V V. 1995. Reversible inhibition of NADPH-cytochrome P450 reductase by alpha-lipoic acid. Biochemical and biophysical research communications. Vol. 214, no. 3: 1246-53.

Utepbergenov, D, I; Khramtsov, V, V; Vlassenko, L, P; Markel, A, L; Mazhukin, D, G; Mazhukin, D, G; Volodarsky, L B. 1995. Kinetics of nitric oxide liberation by 3,4-dihydro-1,2-diazete 1,2-dioxides and their vasodilatory properties in vitro and in vivo. Biochemical and biophysical research communications. Vol. 214, no. 3: 1023-32.

Yelinova VI, Khramtsov VV, Salganik RI, Solovjova NA, Kudrjashova LN. 1995. EPR measurement of thiols in the human and rat blood as a method for diagnosis of oxidative damage processes. Magnetic Reson. in Medicine. Vol. 6: 285-287.

Zamaraev KI, Salganik RI, Romannikov VN, Wlassoff WA, Khramtsov VV. 1995. Modelling of Prebiotic Oligopeptide synthesis in the Presence of Zeolites and Kaolin as Catalysis. Kokladi Akademii Nauk (Russia). Vol. 340(6): 779-782.

Balakirev M Yu, Khramtsov VV. 1996. EPR study of free radical decomposition of NN-bis(arilsulfonil) hydroxylamines inorganic solution. J. Organic Chemistry. Vol. 61: 7263-7269.

Dikalov, S; Khramtsov, V; Zimmer, G. 1996. Determination of rate constants of the reactions of thiols with superoxide radical by electron paramagnetic resonance: critical remarks on spectrophotometric approaches. Archives of biochemistry and biophysics. Vol. 326, no. 2: 207-18.

Khlestkin V, Mazhukin D, Tikhonov A, Bagryanskaja I, Gatilov Yu, Utepbergenov D, Khramtsov VV, Volodarsky LB. 1996. Unexpected transfromation of 1,2-bis(N-methoxy-N-nitrosoamino)cycloalkanes: First synthesis of 4,5-dihydro-1,2,3-triazole 2-oxides. Tetrahedron Lett. Vol. 37: 5997-6000.

Khramtsov, V, V; Utepbergenov, D, I; Vol'dman, Ia Iu; Vlasenko, L, P; Markel', A, L; Kiriliuk, I, A; Grigor'ev, I, A; Mazhukin, D, G; Tikhonov, A Ia; Volodarskii, D G. 1996. [Studies of in vitro and in vivo derived 1,2-diazetine and nitronylnitroxide as donors and acceptors of nitric oxide]. Biokhimii?a? (Moscow, Russia). Vol. 61, no. 10: 1731-42.

Paschenko, S, V; Khramtsov, V, V; Skatchkov, M, P; Plyusnin, V, F; Bassenge, E. 1996. EPR and laser flash photolysis studies of the reaction of nitric oxide with water soluble NO trap Fe(II)-proline-dithiocarbamate complex. Biochemical and biophysical research communications. Vol. 225, no. 2: 577-84.

Sergeeva SV, Slepneva IA, Khramtsov VV, Zimmer G, Ulrich H. 1996. Inhibition of enzymes of microsomal monoxigenase system by a-Lipoic and selenolipoic acids. Exp. Toxic Pathol.. Vol. 48: 361-365.

Yelinova, V; Glazachev, Y; Khramtsov, V; Kudryashova, L; Rykova, V; Salganik, R. 1996. Studies of human and rat blood under oxidative stress: changes in plasma thiol level, antioxidant enzyme activity, protein carbonyl content, and fluidity of erythrocyte membrane. Biochemical and biophysical research communications. Vol. 221, no. 2: 300-3.

Balakirev, M.Yu.; Khramtsov, V.V; Zimmer, G. 1997. Modulation of the mitochondrial permeability transition by nitric oxide. European journal of biochemistry. Vol. 246, no. 3: 710-718.

Haseloff, R, F; Kirilyuk, I, A; Dikalov, S, I; Khramtsov, V, V; Utepbergenov, D, I; Blasig, I, E; Grigor'ev, I A. 1997. Synthesis and spin trapping applications of 2,2-dimethyl-d6-4-methyl-2H-imidazole-1-oxide-1-15N. Free radical research. Vol. 26, no. 2: 159-68.

Khramtsov, V, V; Yelinova, V, I; Yelinova, V, I; Reznikov, V, A; Zimmer, G. 1997. Quantitative determination and reversible modification of thiols using imidazolidine biradical disulfide label. Journal of biochemical and biophysical methods. Vol. 35, no. 2: 115-28.

Zamaraev, K, I; Romannikov, V, N; Salganik, R, I; Wlassoff, W, A; Khramtsov, V V. 1997. Modelling of the prebiotic synthesis of oligopeptides: silicate catalysts help to overcome the critical stage. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. Vol. 27, no. 4: 325-37.

Glazachev Yu I, Khramtsov VV, Berezina TA, Volodarsky LB. 1998. Imidazoline biradical spin labels with EPR spectral sensitivity to the local concentration of protons. Applied Magn. Reson.. Vol. 15: 407-415.

Kirilyuk IA, Utepbergenov DI, Mazhukin DG, Fechner K, Mertsch K, Khramtsov VV, Blasig IE and Haseloff RF. 1998. Thiol-Induced Nitric Oxide Release from 3-Halogeno-3,4-dihydrodiazete 1,2-Dioxides. J. Med. Chem. Vol. 41(7): 1027-1033.

Paschenko SV, Dzuba SA, Khramtsov VV, Tsvetkov Yu D. 1998. The Use of pH-Sensitive Nitroxide Spin Probe to Study Diffusion of Acids. Ber. Bumsenges. Phys. Chem. Vol. 102: 224-228.

Zwicker K, Dikalov S, Matuschka S, Mainka L, Hofmann M, Khramtsov VV, Zimmer G. 1998. Oxygen Radical Generation and Enzymatic Properties of Mitochondria in Hypoxia/Reoxygenation. Arzn-Forschung/Drug Research. Vol. 48(1): 629-636.

Khramtsov, V; Berliner, L, J; Clanton, T L. 1999. NMR spin trapping: detection of free radical reactions using a phosphorus-containing nitrone spin trap. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 42, no. 2: 228-34.

Slepneva, I, A; Glupov, V, V; Sergeeva, S, V; Khramtsov, V V. 1999. EPR detection of reactive oxygen species in hemolymph of Galleria mellonella and Dendrolimus superans sibiricus (Lepidoptera) larvae. Biochemical and biophysical research communications. Vol. 264, no. 1: 212-5.

Yelinova, V, I; Khramtsov, V, V; Markel, A L. 1999. Manifestation of oxidative stress in the pathogenesis of arterial hypertension in ISIAH rats. Biochemical and biophysical research communications. Vol. 263, no. 2: 450-3.

Hassanain, H, H; Sharma, Y, K; Moldovan, L; Khramtsov, V; Berliner, L, J; Duvick, J, P; Goldschmidt-Clermont, P J. 2000. Plant rac proteins induce superoxide production in mammalian cells. Biochemical and biophysical research communications. Vol. 272, no. 3: 783-8.

Khramtsov VV, Grigor'ev LA, Foster MA, Lurie DJ, Nicholson I. 2000. Biological applications of spin pH probes. Cell. Mol. Biol.. Vol. 46(8): 1361-1374.

Khramtsov, V, V; Grigor'ev, I, A; Foster, M, A; Lurie, D, J; Nicholson, I. 2000. Biological applications of spin pH probes. Cellular and molecular biology. Vol. 46, no. 8: 1361-74.

Berliner, L, J; Khramtsov, V; Fujii, H; Clanton, T L. 2001. Unique in vivo applications of spin traps. Free radical biology & medicine. Vol. 30, no. 5: 489-99.

Glazachev Yu I, Grigor'ev IA, Reijerse EJ, Khramtsov VV. 2001. EPR Studies of 15N-and 2H-Substituted pH-Sensitive Spin Probes of Imidazoline and Imidazolidine Types. Applied Magn. Reson.. Vol. 20: 489-505.

Khramtsov, V, V; Reznikov, V, A; Berliner, L, J; Litkin, A, K; Grigor'ev, I, A; Clanton, T L. 2001. NMR spin trapping: detection of free radical reactions with a new fluorinated DMPO analog. Free radical biology & medicine. Vol. 30, no. 10: 1099-107.

Markel', A, L; Elinova, V, I; Khramtsov, V V. 2001. [Oxidative stress in pathogenesis of arterial hypertension in ISIAH rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. Vol. 87, no. 5: 594-9.

Sergeeva, S, V; Slepneva, I, A; Khramtsov, V V. 2001. Effect of selenolipoic acid on peroxynitrite-dependent inactivation of NADPH-cytochrome P450 reductase. Free radical research. Vol. 35, no. 5: 491-7.

Berliner LJ, Khramtsov VV, Clanton TL, Fuji H. 2002. NMR and MRI Spin Trapping: Using NMR to learn about free radical reactions. Current Topics in Biophysics. Vol. 26(1): 89-95.

Bhatt, Nitin, Y; Kelley, Todd, W; Khramtsov, Valery, V; Wang, Yijie; Lam, Gregory, K; Clanton, Thomas, L; Marsh, Clay B. 2002. Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes. Journal of immunology (Baltimore, Md. : 1950). Vol. 169, no. 11: 6427-34.

Khramtsov Vv, Bobko AA, Popov SA, Rezinkov VA, Bagryanskaya EG, Clanton TL. 2002. New series of fluorine-containing probes for NO detection using EPR and NMR spin trapping. Free Radical Biological Medicine. Vol. 33(Suppl 2): S377.

Khramtsov VV, Grigor'ev IA, Kirilyuk IA, Ilangovan G, Kuppusamy P. 2002. In vivo EPR measurement of tissue acidosis during myocardial ischemia using pH-sensitive nitroxides. Free Radical Biological Medicine. Vol. 33(Suppl 2): S423-S424.

Elinova, V, I; Bobko, A, A; Mazhukin, D, G; Markel', A, L; Khramtsov, V V. 2003. [New donors and acceptors of nitrogen oxide as a potential therapeutical agents]. Bioorganicheskaia khimiia. Vol. 29, no. 4: 434-41.

Foster, Margaret, A; Grigor'ev, Igor, A; Lurie, David, J; Khramtsov, Valery, V; McCallum, Stephen; Panagiotelis, Ioannis; Hutchison, James M, S; Koptioug, Andrei; Nicholson, Ian. 2003. In vivo detection of a pH-sensitive nitroxide in the rat stomach by low-field ESR-based techniques. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Vol. 49, no. 3: 558-67.

Kirilyuk IA, Shevelev TG, Morozov DA, Khromovskih EL, Skuridin NG, Khramtsov VV, Grigor'ev IA. 2003. Grignard Reagent Addition to 5-Alkylamino-4H-Imidazole 3-Oxides: Synthesis of New pH-Sensitive Spin Probes. Synthesis. Vol. N 10: 1-8.

Potapenko DI, Bagryanskaya EG, Reznikov VV, Clanton TL, Khramtsov VV. 2003. NMR and EPR studies of the reaction of nucleophilic addition of (bi) sulfite to the nitrone spin trap DMPO. Magn. Reson. Chem.. Vol. 41: 603-608.

Potapenko, Dmitrii, I; Clanton, Thomas, L; Bagryanskaya, Elena, G; Gritsan, Nina, P; Reznikov, Vladimir, A; Khramtsov, Valery V. 2003. Nonradical mechanism of (bi)sulfite reaction with DEPMPO: cautionary note for SO3*- radical spin trapping. Free radical biology & medicine. Vol. 34, no. 2: 196-206.

Reznikov VA, Skuridin NG, Khromavskikh EL, Khramtsov VV. 2003. A new series of lipophilis pH-sensitive spin probes. Russian Chemical Bulletin. Vol. 52(9): 2052-2056.

Slepneva, Irina, A; Komarov, Denis, A; Glupov, Viktor, V; Serebrov, Valery, V; Khramtsov, Valery V. 2003. Influence of fungal infection on the DOPA-semiquinone and DOPA-quinone production in haemolymph of Galleriamellonella larvae. Biochemical and biophysical research communications. Vol. 300, no. 1: 188-91.

Bobko, Andrey, A; Bagryanskaya, Elena, G; Reznikov, Vladimir, A; Kolosova, Nataljya, G; Clanton, Thomas, L; Khramtsov, Valery V. 2004. Redox-sensitive mechanism of no scavenging by nitronyl nitroxides. Free radical biology & medicine. Vol. 36, no. 2: 248-58.

Khramtsov VV, Grigor'ev IA, Foster MA, Lurie DJ, Zweier JL, Kuppusamy P. 2004. Spin pH and SH probes: enhancing functionality of EPR-based techniques. Spectroscopy - An International Journal.

Khramtsov, Valery, V; Grigor'ev, Igor, A; Foster, Margaret, A; Lurie, David J. 2004. In vitro and in vivo measurement of pH and thiols by EPR-based techniques. Antioxidants & redox signaling. Vol. 6, no. 3: 667-76.

Kirilyuk, Igor, A; Bobko, Andrey, A; Grigor'ev, Igor, A; Khramtsov, Valery V. 2004. Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction. Organic & biomolecular chemistry. Vol. 2, no. 7: 1025-30.

Lozinskaia, Ia, L; Slepneva, I, A; Khramtsov, V, V; Glupov, V V. 2004. [Change of the antioxidant status and free radicals production in hemolymph of Galleria mellonella larvae in microsporidiosis.]. Zhurnal evoliutsionnoi biokhimii i fiziologii. Vol. 40, no. 2: 99-103.

Potapenko DI, Bagryanskaya EG, Tsentalovich Yu P, Reznikov VV, Clanton TL, Khramtsov VV. 2004. Reversible reactions of thiols and thiyl radicals with nitrone spin traps. J. Med. Chem - SUBMITTED.

Khramtsov, V.V. 2005. Biological Imaging and Spectroscopy of pH. Current Organic Chemistry. Vol. 9: 909-923.

Kirilyuk, Igor, A; Bobko, Andrey, A; Khramtsov, Valery, V; Grigor'ev, Igor A. 2005. Nitroxides with two pK values--useful spin probes for pH monitoring within a broad range. Organic & biomolecular chemistry. Vol. 3, no. 7: 1269-74.

Komarov, Denis, A; Slepneva, Irina, A; Glupov, Viktor, V; Khramtsov, Valery V. 2005. Superoxide and hydrogen peroxide formation during enzymatic oxidation of DOPA by phenoloxidase. Free radical research. Vol. 39, no. 8: 853-8.

Glazachev, Yu, I; Khramtsov, V V. 2006. Fluorescence recovery under decaying photobleaching irradiation: concept and experiment. Journal of fluorescence. Vol. 16, no. 6: 773-81.

Komarov, D, A; Slepneva, I, A; Dubovskii, I, M; Grizanova, E, V; Khramtsov, V, V; Glupov, V V. 2006. Generation of superoxide radical and hydrogen peroxide in insect hemolymph in the course of immune response. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian. Vol. 411: 482-5.

Bobko AA, Dhimitruka I, Zweier JL, Khramtsov VV. 2007. Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment. J. Am. Chem. Soc.. Vol. 129,, no. 23: 7240-7241.

Bobko, Andrey, A; Kirilyuk, Igor, A; Grigor'ev, Igor, A; Zweier, Jay, L; Khramtsov, Valery V. 2007. Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione. Free radical biology & medicine. Vol. 42, no. 3: 404-12.

Dhimitruka I, Velayutham M, Bobko AA, Khramtsov VV, Villamena FA, Hadad CM, and Zweier, JL. 2007. Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging. Bioorg. Medicinal Chem. Lett.. Vol. 17: 6801-6805.

Samouilov, A., Zweier, J.L., Woldman, Ya., Khramtsov, V.V. 2007. Magnetic Resonance Study of the Transmembrane Nitrite Diffusion. Nitric Oxide. Vol. 16: 362-370.

Samouilov, A; Woldman, Ya Yu; Zweier, J, L; Khramtsov, V V. 2007. Magnetic resonance study of the transmembrane nitrite diffusion. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. Vol. 16, no. 3: 362-70.

Swartz, H.M., Khan, N., and Khramtsov, V.V. 2007. Use of Electron Paramagnetic Resonance Spectroscopy to Evaluate the Redox State In Vivo. Antioxid. Redox Signal. Vol. 9, no. 10: 1757-1771.

Wang, Yijie; Zeigler, Mandy, M; Lam, Gregory, K; Hunter, Melissa, G; Eubank, Tim, D; Khramtsov, Valery, V; Tridandapani, Susheela; Sen, Chandan, K; Marsh, Clay B. 2007. The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. American journal of respiratory cell and molecular biology. Vol. 36, no. 1. (January): 68-77. (IF: 4.593)

Bratasz A, Selvendiran K, Wasowicz T, Bobko A, Khramtsov VV, Ignarro LJ and Kuppusamy P. 2008. NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. Journal of Translational Medicine. Vol. 6, no. 9. doi:10.1186/1479-5876-6-9. (IF: 2.935)

Dhimitruka I, Bobko AA, Hadad C, Zweier J, Khramtsov, VV. 2008. Synthesis and Characterization of Amino Derivatives of Persistent Trityl Radicals as Dual Function pH and Oxygen Paramagnetic Probes. J. Am. Chem. Soc.. Vol. 130, no. 32: 10780-10787. (IF: 7.885)

Polovyanenko DN, Plyusnin VF, Reznikov VA, Khramtsov VV, Bagryanskaya EG. 2008. Mechanistic Studies of the Reactions of Nitrone Spin Trap PBN with Glutathiyl Radical. J. Phys. Chem. B.. Vol. 112: 4841-4847. (IF: 4.086)

Roshchupkina GI, Bobko AA, Bratasz A, Reznikov VA, Kuppusamy P and Khramtsov VV. 2008. In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe. Free Radic. Biol. Medicine. Vol. 45: 312-320. (IF: 4.813)

Positions

1980 - 1986

Ph.D. Student Advisor, Institute of Chemical Kinetics & Combustion, Novosibirsk, Russia, Institute of Chemical Kinetics & Combustion.

1986 - 1989

Research Scientist, Institute of Chemical Kinetics & Combustion, Novosibirsk, Russia. Chemical Kinetics & Combustion.

1988 - 2001

Department Head, Novosibirsk State University, Department of Physical Chemistry Biophysical Program. Novobirirsk, Russian Federation.

1989 - 1991

Alexander von Humboldt Foundation Fellow, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany. Biophysical Chemistry.

1991 - 1996

Senior Research Scientist,, Institute of Chemical Kinetics & Combustion, Novosibirsk, Russia. Department Head, Biophysical Group.

1996 - 1997

Visiting Professor, Frankfurt University, Klinikum, Germany. Zentrum der Biologishen Chemie.

1997 - 1998

Visiting Scholar, The Ohio State University, Columbus, Fogarty Foundation Fellowship. Chemistry Department.

1998 - 2001

Department Head, Institute of Chemical Kinetics & Combustion, Novosibirsk, Russia. Department of Biophysics.

2001 - 2004

Senior Research Scientist, The Ohio State University, Columbus, OH, Dorothy M. Davis Heart & Lung Research Institute. Columbus, Ohio.

Presentations

Other Presentations

Local

Dr. Valery V Khramtsov. 1999. Imidazoline and imidazolidine nitroxides as spin probes for ESR monitoring of local chemmical environment in vivo. Presented at International workshop on Techniques and Bio-Medical Applications of In Vivo EPR and PEDRI. Aberdeen, Scotland. (September 12)

Dr. Valery V Khramtsov. 2000. Imidazoline Nitroxides in Spin Labeling: Combining Functional Chemical Reactivity and Stability of Nitroxyl Fragment. Presented at 6th Internaltional Symposium on Spin Tapping. Marseille, France. (August 27)

Dr. Valery V Khramtsov. 2000. New Approached in Spin Labeling and Spin Trapping. Presented at International Summer School on Biophysics. Rovinj, Croatia. (September 15)

Dr. Valery V Khramtsov. 2001. In vivo and in vitro EPR studies using imidazoline nitroxide spin probes. Presented at International workshop on In Vivo EPR and Related Studies. Hannover, NH. (September 8)

Dr. Valery V Khramtsov. 2001. Enhanced opportunities in design of spin labeling experiment using imidazoline nitroxides. Presented at 3rd International Conference on Nitroxide Radicals. Kaiserslautern, Germany. (September 23)

Dr. Valery V Khramtsov. 2001. New NO donors and acceptors as potential therapeutic agents. Presented at AvHumboldt Russian-German Conference on Biomedicine. Moscow, Russia. (November 19)

Dr. Valery V Khramtsov. 2002. Magnetic Resonance Spin Trapping: from EPR towards NMR. Presented at 35th Annual Meeting of EPR groups of the Royal Society of Chemistry. Aberdeen, Great Britian. (April 7)

Dr. Valery V Khramtsov. 2002. NMR Spin trapping of free radicals: limitations, advantages and future directions. Presented at 7th International Symposium on Spin Trapping. Chapel Hill, NC USA. (July 7)

Dr. Valery V Khramtsov. 2002. NMR spin trapping: a new way to visualize EPR silent radical chemistry. Presented at VI Voevodsky Conference on Physics and Chemistry of Elementary Chemical Processes. Novosibirsk. (July 21)

Dr. Valery V Khramtsov. 2003. Spin pH and SH probes: enhancing functionality of EPR-based techniques. Presented at 2nd International Conference on Biomedical Spectroscopy. London, United Kingdom. (July 5)

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