Dr Pravin T P Kaumaya

316 Tzagournis Medical Research Facilty
420 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-7028

Email: kaumaya.1@osu.edu

Current OSU Appointments

Professor, Obstetrics & Gynecology

Professor, Microbiology Administration

Professor, Molecular & Cellular Biochemistry

Professor, Molecular Virology, Immunology & Medical Genetics

Degrees

1976	B.S.(Honors), University College London, Biochemistry

1981	Ph.D., University of Portsmouth, Medicinal Chemistry

1983	Postdoctoral, University of Texas, Medicinal Chemistry

Honors

Chair, National Institute of Health Study Section on Vaccines.

2006

Fellow.

Memberships

Chair. Chair, National Institute of Health Study Section on Vaccines

Peer Reviewed Journal Articles

Casten, L, A; Kaumaya, P; Pierce, S K. 1988. Enhanced T cell responses to antigenic peptides targeted to B cell surface Ig, Ia, or class I molecules. The Journal of experimental medicine. Vol. 168, no. 1: 171-80.

Pierce, S, K; Morris, J, F; Grusby, M, J; Kaumaya, P; van Buskirk, A; Srinivasan, M; Crump, B; Smolenski, L A. 1988. Antigen-presenting function of B lymphocytes. Immunological reviews. Vol. 106: 149-80.

Hogrefe, H, H; Kaumaya, P, T; Goldberg, E. 1989. Immunogenicity of synthetic peptides corresponding to flexible and antibody-accessible segments of mouse lactate dehydrogenase (LDH)-C4. The Journal of biological chemistry. Vol. 264, no. 18: 10513-9.

Kaumaya, P, T; Berndt, K, D; Heidorn, D, B; Trewhella, J; Kezdy, F, J; Goldberg, E. 1990. Synthesis and biophysical characterization of engineered topographic immunogenic determinants with alpha alpha topology. Biochemistry. Vol. 29, no. 1: 13-23.

Smolenski, L, A; Kaumaya, P; Atassi, M, Z; Pierce, S K. 1990. Characteristics of peptides which compete for presented antigen-binding sites on antigen-presenting cells. European journal of immunology. Vol. 20, no. 5: 953-60.

Kaumaya, P, T; VanBuskirk, A, M; Goldberg, E; Pierce, S K. 1992. Design and immunological properties of topographic immunogenic determinants of a protein antigen (LDH-C4) as vaccines. The Journal of biological chemistry. Vol. 267, no. 9: 6338-46.

Kaumaya, P, T; Kobs-Conrad, S; Seo, Y, H; Lee, H; VanBuskirk, A, M; Feng, N; Sheridan, J, F; Stevens, V. 1993. Peptide vaccines incorporating a 'promiscuous' T-cell epitope bypass certain haplotype restricted immune responses and provide broad spectrum immunogenicity. Journal of molecular recognition : JMR. Vol. 6, no. 2: 81-94.

Kobs-Conrad, S; Lee, H; DiGeorge, A, M; Kaumaya, P T. 1993. Engineered topographic determinants with alpha beta, beta alpha beta, and beta alpha beta alpha topologies show high affinity binding to native protein antigen (lactate dehydrogenase-C4). The Journal of biological chemistry. Vol. 268, no. 34: 25285-95.

Srinivasan, M; Domanico, S, Z; Kaumaya, P, T; Pierce, S K. 1993. Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted T cell response. European journal of immunology. Vol. 23, no. 5: 1011-6.

Mullenix, M, C; Kaumaya, P, T; Mortensen, R F. 1994. Cell attachment peptide of C-reactive protein: critical amino acids and minimum length. Journal of cellular biochemistry. Vol. 54, no. 3: 343-53.

Conrad, S, F; Byeon, I, J; DiGeorge, A, M; Lairmore, M, D; Tsai, M, D; Kaumaya, P T. 1995. Immunogenicity and conformational properties of an N-linked glycosylated peptide epitope of human T-lymphotropic virus type 1 (HTLV-I). Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity. Vol. 1, no. 2: 83-92.

Green, J, M; Gu, L; Ifkovits, C; Kaumaya, P, T; Conrad, S; Pierce, S K. 1995. Generation and characterization of monoclonal antibodies specific for members of the mammalian 70-kDa heat shock protein family. Hybridoma. Vol. 14, no. 4: 347-54.

Kaumaya, P, T; Conrad, S, F; DiGeorge, A, M; Lairmore, M D. 1995. Glycosylation-dependent peptide antigenic determinants of env gp46 HTLV-1. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. Vol. 9 Suppl 1: S133-8.

Lairmore, M, D; DiGeorge, A, M; Conrad, S, F; Trevino, A, V; Lal, R, B; Kaumaya, P T. 1995. Human T-lymphotropic virus type 1 peptides in chimeric and multivalent constructs with promiscuous T-cell epitopes enhance immunogenicity and overcome genetic restriction. Journal of virology. Vol. 69, no. 10: 6077-89.

Lairmore, M, D; Lal, R, B; Kaumaya, P T. 1995. Evaluation of immunodominant epitopes of human T-lymphotropic virus type 1 (HTLV-I) using synthetic peptides. Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity. Vol. 1, no. 3: 117-22.

Triozzi, P, L; Stoner, G, D; Kaumaya, P T. 1995. Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene. Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity. Vol. 1, no. 3: 185-92.

Bakaletz, L, O; Leake, E, R; Billy, J, M; Kaumaya, P T. 1997. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine. Vol. 15, no. 9: 955-61.

Wilmer, W, A; Kaumaya, P, T; Ember, J, A; Cosio, F G. 1998. Receptors for the anaphylatoxin C5a (CD88) on human mesangial cells. J Immunol. Vol. 160, no. 11: 5646-52.

Dakappagari, N, K; Douglas, D, B; Triozzi, P, L; Stevens, V, C; Kaumaya, P T. 2000. Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine. Cancer research. Vol. 60, no. 14: 3782-9.

Frangione-Beebe, M; Albrecht, B; Dakappagari, N; Rose, R, T; Brooks, C, L; Schwendeman, S, P; Lairmore, M, D; Kaumaya, P T. 2000. Enhanced immunogenicity of a conformational epitope of human T-lymphotropic virus type 1 using a novel chimeric peptide. Vaccine. Vol. 19, no. 9-10: 1068-81.

Frangione-Beebe, M; Rose, R, T; Kaumaya, P, T; Schwendeman, S P. 2001. Microencapsulation of a synthetic peptide epitope for HTLV-1 in biodegradable poly(D,L-lactide-co-glycolide) microspheres using a novel encapsulation technique. Journal of microencapsulation. Vol. 18, no. 5: 663-77.

Srinivasan, M; Wardrop, R, M; Gienapp, I, E; Stuckman, S, S; Whitacre, C, C; Kaumaya, P T. 2001. A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro. J Immunol. Vol. 167, no. 1: 578-85.

Srinivasan, Mythily; Gienapp, Ingrid, E; Stuckman, Scott, S; Rogers, Connie, J; Jewell, Scott, D; Kaumaya, Pravin T, P; Whitacre, Caroline C. 2002. Suppression of experimental autoimmune encephalomyelitis using peptide mimics of CD28. J Immunol. Vol. 169, no. 4: 2180-8.

Sundaram, Roshni; Dakappagari, Naveen, K; Kaumaya, Pravin T P. 2002. Synthetic peptides as cancer vaccines. Biopolymers. Vol. 66, no. 3: 200-16.

Dakappagari, Naveen, K; Pyles, John; Parihar, Robin; Carson, William, E; Young, Donn, C; Kaumaya, Pravin T P. 2003. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol. Vol. 170, no. 8: 4242-53.

Sundaram, Roshni; Sun, Yiping; Walker, Christopher, M; Lemonnier, Francois, A; Jacobson, Steven; Kaumaya, Pravin T P. 2003. A novel multivalent human CTL peptide construct elicits robust cellular immune responses in HLA-A*0201 transgenic mice: implications for HTLV-1 vaccine design. Vaccine. Vol. 21, no. 21-22: 2767-81.

Tomaru, Utano; Yamano, Yoshihisa; Nagai, Masahiro; Maric, Dragan; Kaumaya, Previn T, P; Biddison, William; Jacobson, Steven. 2003. Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections. Nature medicine. Vol. 9, no. 4: 469-76.

Sundaram, R; Beebe, M; Kaumaya, P T P. 2004. Structural and immunogenicity analysis of chimeric B-cell epitope constructs derived from the gp46 and gp21 subunits of the envelope glycoproteins of HTLV-1. The journal of peptide research : official journal of the American Peptide Society. Vol. 63, no. 2: 132-40.

Sundaram, Roshni; Lynch, Marcus, P; Rawale, Sharad, V; Sun, Yiping; Kazanji, Mirdad; Kaumaya, Pravin T P. 2004. De novo design of peptide immunogens that mimic the coiled coil region of human T-cell leukemia virus type-1 glycoprotein 21 transmembrane subunit for induction of native protein reactive neutralizing antibodies. The Journal of biological chemistry. Vol. 279, no. 23: 24141-51.

Sundaram, Roshni; Lynch, Marcus, P; Rawale, Sharad; Dakappagari, Naveen; Young, Donn; Walker, Christopher, M; Lemonnier, Francois; Jacobson, Steven; Kaumaya, Pravin T P. 2004. Protective efficacy of multiepitope human leukocyte antigen-A*0201 restricted cytotoxic T-lymphocyte peptide construct against challenge with human T-cell lymphotropic virus type 1 Tax recombinant vaccinia virus. Journal of acquired immune deficiency syndromes. Vol. 37, no. 3: 1329-39.

Allen, S, D; Rawale, S, V; Whitacre, C, C; Kaumaya, P T P. 2005. Therapeutic peptidomimetic strategies for autoimmune diseases: costimulation blockade. The journal of peptide research : official journal of the American Peptide Society. Vol. 65, no. 6: 591-604.

Dakappagari, N, K; Sundaram, R; Rawale, S; Liner, A; Galloway, D, R; Kaumaya, P T P. 2005. Intracellular delivery of a novel multiepitope peptide vaccine by an amphipathic peptide carrier enhances cytotoxic T-cell responses in HLA-A*201 mice. The journal of peptide research : official journal of the American Peptide Society. Vol. 65, no. 2: 189-99.

Dakappagari, Naveen, K; Lute, Kenneth, D; Rawale, Sharad; Steele, Joan, T; Allen, Stephanie, D; Phillips, Gary; Reilly, R Todd; Kaumaya, Pravin T P. 2005. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. The Journal of biological chemistry. Vol. 280, no. 1: 54-63.

Kimura, Yoichi; Gushima, Toshifumi; Rawale, Sharad; Kaumaya, Pravin; Walker, Christopher M. 2005. Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection. Journal of virology. Vol. 79, no. 8: 4870-6.

Kinoshita, Y; Kuratsukuri, K; Newman, N; Rovito, P, M; Kaumaya, P T, P; Wang, C, Y; Haas, G P. 2005. Targeting epitopes in prostate-specific membrane antigen for antibody therapy of prostate cancer. Prostate cancer and prostatic diseases. Vol. 8, no. 4: 359-63.

Lynch, Marcus, P; Kaumaya, Pravin T P. 2006. Advances in HTLV-1 peptide vaccines and therapeutics. Current protein & peptide science. Vol. 7, no. 2: 137-45.

Allen, Stephanie, D; Garrett, Joan, T; Rawale, Sharad, V; Jones, Audra, L; Phillips, Gary; Forni, Guido; Morris, John, C; Oshima, Robert, G; Kaumaya, Pravin T P. 2007. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. Journal of immunology (Baltimore, Md. : 1950). Vol. 179, no. 1: 472-82. (IF: 6.293)

Garrett, Joan, T; Rawale, Sharad; Allen, Stephanie, D; Phillips, Gary; Forni, Guido; Morris, John, C; Kaumaya, Pravin T P. 2007. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. Journal of immunology (Baltimore, Md. : 1950). Vol. 178, no. 11: 7120-31. (IF: 6.293)