OSU:pro
Dr Sissy Meihua Jhiang
210 Hamilton Hall
1645 Neil Ave
Columbus, OH 43210
Phone: (614) 292-4312
Email: jhiang.1@osu.edu
Current OSU Appointments
Professor, Physiology and Cell Biology
Professor, Veterinary Biosciences
Chapters In Books
Busch H, Busch RK, Freeman JW, Larson R, Haidar M, Jhiang S, Valdez B, Zhang W. 1990. Biotechnology and Human Tumor Nucleolar Antigen. In Nuclear Structure and Function. Edited by Harris JR, Zbarsky IB. New York, NY: Plenum Press. 237-242.
LaPerle KMD, Jhiang SM. 2002. Iodine: Symporter and oxidation, thyroid hormone biosynthesis. In Encyclopedia of Hormones. Edited by Henry HL, Norman AW. San Diego, CA: Academic Press.
Degrees
| 1983 | M.S., National Tsing Hua University, Radiation Biology |
| 1987 | Ph.D., University of Texas, Zoology |
Editorial Activities
Editorial Board
| 2001 - 2004 | Endocrinology. |
| 1998 - present | Thyroid. |
Journal Reviewer
| 2007 - present | Journal of Endocrinology. |
| 2007 - present | Thyroid. |
| 2007 - present | Oncogene. |
| 2007 - present | The Journal of Clinical Investigation. |
| 2007 - present | Cancer. |
| 2007 - present | Journal of Nutrition Biochemistry. |
| 2007 - present | Biotechniques. |
| 2007 - present | Life Sciences. |
| 2007 - present | Clinical Endocrinology. |
| 2007 - present | Journal of Endocrinology and Metabolism. |
| 2007 - present | Science. |
| 2007 - present | Endocrine Review. |
| 2007 - present | Molecular and Cellular Biology. |
| 2007 - present | Cancer Research. |
| 2007 - present | Molecular and Chemical Neuropathology. |
| 2007 - present | Journal of Gene. |
| 2007 - present | Cancer Detection and Prevention. |
Honors
| 1992 | Henry Christian Award. |
| 2002 | Van Meter Award. |
| 2003 | Excellence in Research Award. |
| 2005 | Fellow, AAAS Fellow. American Association for the Advancement of Science (AAAS), Washington, DC, United States. |
Memberships
| Member. American Thyroid Association |
| Member. The Endocrine Society |
| Member. American Association for Cancer Research |
| 1984 - 1987 | Member. Phi Kappa Phi Honor Society |
| 1993 - 1995 | Member. The Ohio State University, Ohio State Biochemistry Graduate Program. Admissions and Recruitment |
| 1994 - 1995 | Member. The Ohio State University, College of Medicine. Research Committee |
| 1994 - 1995 | Member. The Ohio State University Comprehensive Cancer Center. ACS Institutional Grant Evaluation Committee |
| 1994 - 2001 | Grant Reviewer. The Ohio State University. Seed Grants |
| 1994 | Grant Reviewer. Children's Hospital. Research Foundation |
| 1994 - 1995 | Grant Reviewer. The Ohio State University, Comprehensive Cancer Center. Interdisciplinary Program Development Grants |
| 1994 | Grant Reviewer. The Ohio State University. Cancer P20 Program Development Grants |
| 1994 - 1995 | Member. The Ohio State University, Department of Physiology and Cell Biology. Seminar Committee |
| 1994 - 1999 | Member. The Ohio State University, Department of Physiology and Cell Biology. Graduate Studies Committee |
| 1995 | Grant Reviewer. American Cancer Society. Cancer Control Grants |
| 1995 - 1996 | Member. The Ohio State University. Molecular Neurobiology Search Committee |
| 1995 - 2000 | Member. The Ohio State University, Comprehensive Cancer Center. Clinical Scientific Review Committee |
| 1996 - 2000 | Member. The Ohio State University. Transgenic Animal Advisory Committee |
| 1996 - 1998 | Member. The Ohio State University, College of Medicine. Graduate Education Committee |
| 1996 - 1998 | Member. The Ohio State University, College of Medicine. Research Committee |
| 1996 - 2000 | Member. The Ohio State University, Molecular, Cellular and Developmental Medicine Graduate Program. Graduate Studies Committee |
| 1996 | Grant Reviewer. Children's Hospital. Research Foundation |
| 1996 - 2000 | Member. The Ohio State University, Department of Physiology and Cell Biology. Merit Committee |
| 1997 - 2000 | Member. The Ohio State University, Department of Physiology and Cell Biology. Strategic Planning Committee |
| 1997 | Co-Chair. American Thyroid Association, 70th Annual Meeting, Colorado Springs CO. Symposium on "Cancer" |
| 1998 | Grant Reviewer. The Ohio State University Comprehensive Cancer Center. Therapeutics Program Development Grants |
| 1998 - 2001 | Member. The Ohio State University, Department of Physiology and Cell Biology. Promotion and Tenure Committee |
| 1998 - 1999 | Member. The Ohio State University, Department of Physiology and Cell Biology. Seminar Committee |
| 1999 - 2000 | Grant Reviewer. VA Biomedical Research Grant. Merit Review |
| 1999 | Grant Reviewer. National Institutes of Health, National Cancer Institute. Program Project Application: Virology and Genetics of Cancer in Mouse Models |
| 1999 - 2006 | Member. American Thyroid Association. Program Committee for Annual Meeting |
| 2000 - 2001 | Member. National Institutes of Health. Endocrinology Study Section |
| 2001 - 2004 | Member. National Institutes of Health. Endocrinology Study Section |
| 2001 - present | Member. The Ohio State University, Department of Physiology and Cell Biology. Graduate Study Committee |
| 2001 | Member. American Thyroid Association. Membership Committee |
| 2001 - present | Member. The Ohio State University, M.D./Ph.D. Training Program. Steering Committee |
| 2001 - present | Member. The Ohio State University, M.D./Ph.D. Training Program. Admission Committee |
| 2001 - present | Member. The Ohio State University, Comprehensive Training in Oral and Craniofacial Sciences. Executive Committee |
| 2001 - present | Member. The Ohio State University. T32 Hematology/Oncology Training Program Review Committee |
| 2001 - 2004 | Grant Reviewer. National Institutes of Health. Endocrinology Study Section |
| 2001 | Grant Reviewer. American Cancer Society, Ohio Division. Pilot Grant Review Committee |
| 2002 - present | Member. The Ohio State University. Biomedical Imaging Committee |
| 2002 | Member. The Ohio State University, Department of Physiology and Cell Biology. Subcommittee for Patterns of Administration |
| 2002 - 2005 | Member. The Ohio State University, Department of Physiology and Cell Biology. Appointment, Promotion, and Tenure Committee |
| 2003 | Advisor. The Ohio State University. P01 Project entitled "Hormonal and Molecular Targets in Breast Cancer Therapy" |
| 2003 | Member. The Ohio State University, Veterinary Clinical Pathology. Search Committee |
| 2003 - 2004 | Chair. The Ohio State University, Department of Physiology and Cell Biology. Appointment, Promotion, and Tenure Committee |
| 2003 | Member. The Ohio State University. NCI U01 Internal Scientific Advisory Committee for grant "Mouse models of human cancer" |
| 2003 | Member. W.M. Keck Center for Cancer Gene, The University of Texas, M.D. Anderson Cancer Center, Houston TX. External Scientific Advisory Board, P01 Project: "Novel Approaches to Cancer Gene Therapy" |
| 2004 - 2005 | Grant Reviewer. National Institutes of Health. Cancer Molecular Pathology Study Section |
| 2004 - 2005 | Member. National Institutes of Health. Cancer Molecular Pathology Study Section |
| 2005 - present | Member. F1000 Medicine |
| 2005 | Grant Reviewer. Cancer Research UK. Grant Review |
| 2005 | Grant Reviewer. National Institutes of Health, National Cancer Institute. Drug Discovery P01 Review |
| 2005 | Grant Reviewer. Cancer Research Ireland |
| 2005 - present | Member. F1000 Medicine |
| 2005 | Grant Reviewer. Italian Association for Cancer Research. Grant Review |
| 2006 | Grant Reviewer. United States-Israel Binational Science Foundation. Grant Review |
| 2006 | Member. United States-Israel Binational Science Foundation. Grant Review |
| 2006 | Member. American Thyroid Association Annual Meeting. Program Committee |
| 2006 | Member. NIH ICER. Study Section |
| 2006 | Member. NIH. Oncology Fellowship and Area Study Section |
Peer Reviewed Journal Articles
Jhiang, S, M; Garey, J, R; Riggs, A F. 1988. Exon-intron organization in genes of earthworm and vertebrate globins. Science. Vol. 240, no. 4850: 334-6.
Fonagy, A; Henning, D; Jhiang, S; Haidar, M; Busch, R, K; Larson, R; Valdez, B; Busch, H. 1989. Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120. Cancer communications. Vol. 1, no. 4: 243-51.
Jhiang, S, M; Larson, R, G; Busch, H. 1989. Polymerase chain reaction in restriction enzyme mapping. BioTechniques. Vol. 7, no. 8: 818, 820.
Jhiang, S, M; Riggs, A F. 1989. The structure of the gene encoding chain c of the hemoglobin of the earthworm, Lumbricus terrestris. The Journal of biological chemistry. Vol. 264, no. 32: 19003-8.
Jhiang, S, M; Yaneva, M; Busch, H. 1990. Expression of human proliferation-associated nucleolar antigen p120. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. Vol. 1, no. 7: 319-24.
Larson, R, G; Henning, D; Haidar, M, A; Jhiang, S; Lin, W, L; Zhang, W, W; Busch, H. 1990. Genomic structure of the human proliferating cell nucleolar protein P120. Cancer communications. Vol. 2, no. 2: 63-71.
Jhiang, S, M; Chiu, I, M; Mazzaferri, E L. 1991. An STS in the human PTC oncogene located at 10q11.2. Nucleic acids research. Vol. 19, no. 15: 4303.
Yaneva, M; Jhiang, S. 1991. Expression of the Ku protein during cell proliferation. Biochimica et biophysica acta. Vol. 1090, no. 2: 181-7.
Jhiang, S, M; Caruso, D, R; Gilmore, E; Ishizaka, Y; Tahira, T; Nagao, M; Chiu, I, M; Mazzaferri, E L. 1992. Detection of the PTC/retTPC oncogene in human thyroid cancers. Oncogene. Vol. 7, no. 7: 1331-7.
Perlaky, L; Valdez, B, C; Busch, R, K; Larson, R, G; Jhiang, S, M; Zhang, W, W; Brattain, M; Busch, H. 1992. Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct. Cancer research. Vol. 52, no. 2: 428-36.
Jhiang, S, M; Fithian, L; Smanik, P; McGill, J; Tong, Q; Mazzaferri, E L. 1993. Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. FEBS letters. Vol. 318, no. 2: 139-44.
Jhiang, S, M; Mazzaferri, E L. 1994. The ret/PTC oncogene in papillary thyroid carcinoma. The Journal of laboratory and clinical medicine. Vol. 123, no. 3: 331-7.
Jhiang, S, M; Smanik, P, A; Mazzaferri, E L. 1994. Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma. Cancer letters. Vol. 78, no. 1-3: 69-76.
Mazzaferri, E, L; Jhiang, S M. 1994. Differentiated thyroid cancer long-term impact of initial therapy. Transactions of the American Clinical and Climatological Association. Vol. 106: 151-68; discussion 168.
Mazzaferri, E, L; Jhiang, S M. 1994. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. The American journal of medicine. Vol. 97, no. 5: 418-28.
Smanik, P, A; Fithian, L, J; Jhiang, S M. 1994. Thyroid peroxidase expression and DNA polymorphisms in thyroid cancer. Biochemical and biophysical research communications. Vol. 198, no. 3: 948-54.
Xing, S; Tong, Q; Suzuki, T; Jhiang, S M. 1994. Alternative splicing of the ret proto-oncogene at intron 4. Biochemical and biophysical research communications. Vol. 205, no. 3: 1526-32.
Smanik, P, A; Furminger, T, L; Mazzaferri, E, L; Jhiang, S M. 1995. Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma. Human molecular genetics. Vol. 4, no. 12: 2313-8.
Tong, Q; Li, Y; Smanik, P, A; Fithian, L, J; Xing, S; Mazzaferri, E, L; Jhiang, S M. 1995. Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene. Oncogene. Vol. 10, no. 9: 1781-7.
Jhiang, S, M; Fithian, L; Weghorst, C, M; Clark, O, H; Falko, J, M; O'Dorisio, T, M; Mazzaferri, E L. 1996. RET mutation screening in MEN2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinoma. Thyroid : official journal of the American Thyroid Association. Vol. 6, no. 2: 115-21.
Jhiang, S, M; Sagartz, J, E; Tong, Q; Parker-Thornburg, J; Capen, C, C; Cho, J, Y; Xing, S; Ledent, C. 1996. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology. Vol. 137, no. 1: 375-8.
Jossart, G, H; O'Brien, B; Cheng, J, F; Tong, Q; Jhiang, S, M; Duh, Q; Clark, O, H; Weier, H U. 1996. A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1. Cytogenetics and cell genetics. Vol. 75, no. 4: 254-7.
Smanik, P, A; Liu, Q; Furminger, T, L; Ryu, K; Xing, S; Mazzaferri, E, L; Jhiang, S M. 1996. Cloning of the human sodium lodide symporter. Biochemical and biophysical research communications. Vol. 226, no. 2: 339-45.
Xing, S; Smanik, P, A; Oglesbee, M, J; Trosko, J, E; Mazzaferri, E, L; Jhiang, S M. 1996. Characterization of ret oncogenic activation in MEN2 inherited cancer syndromes. Endocrinology. Vol. 137, no. 5: 1512-9.
Halling KC, Bufill JA, Cotter M, Artz SA, Carpenter AB, Schaid D, Hartman-Adams H, Chang HH, Boustany MM, Fithian L, Jhiang SM, Thibodeau SN. 1997. Age-Related Disease Penetrance in a Large Medullary Thyroid Cancer Family With a Codon 609 RET Gene Mutation. Molecular Diagnosis. Vol. 2: 277-286.
Sagartz, J, E; Jhiang, S, M; Tong, Q; Capen, C C. 1997. Thyroid-stimulating hormone promotes growth of thyroid carcinomas in transgenic mice with targeted expression of the ret/PTC1 oncogene. Laboratory investigation; a journal of technical methods and pathology. Vol. 76, no. 3: 307-18.
Smanik, P, A; Ryu, K, Y; Theil, K, S; Mazzaferri, E, L; Jhiang, S M. 1997. Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter. Endocrinology. Vol. 138, no. 8: 3555-8.
Tong, Q; Ryu, K, Y; Jhiang, S M. 1997. Promoter characterization of the rat Na+/I- symporter gene. Biochemical and biophysical research communications. Vol. 239, no. 1: 34-41.
Tong, Q; Xing, S; Jhiang, S M. 1997. Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity. The Journal of biological chemistry. Vol. 272, no. 14: 9043-7.
Jhiang, S, M; Cho, J, Y; Furminger, T, L; Sagartz, J, E; Tong, Q; Capen, C, C; Mazzaferri, E L. 1998. Thyroid carcinomas in RET/PTC transgenic mice. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. Vol. 154: 265-70.
Jhiang, S, M; Cho, J, Y; Ryu, K, Y; DeYoung, B, R; Smanik, P, A; McGaughy, V, R; Fischer, A, H; Mazzaferri, E L. 1998. An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues. Endocrinology. Vol. 139, no. 10: 4416-9.
Kosugi, S; Inoue, S; Matsuda, A; Jhiang, S M. 1998. Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients. The Journal of clinical endocrinology and metabolism. Vol. 83, no. 9: 3373-6.
Kosugi, S; Sato, Y; Matsuda, A; Ohyama, Y; Fujieda, K; Inomata, H; Kameya, T; Isozaki, O; Jhiang, S M. 1998. High prevalence of T354P sodium/iodide symporter gene mutation in Japanese patients with iodide transport defect who have heterogeneous clinical pictures. The Journal of clinical endocrinology and metabolism. Vol. 83, no. 11: 4123-9.
Pohlenz, J; Rosenthal, I, M; Weiss, R, E; Jhiang, S, M; Burant, C; Refetoff, S. 1998. Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site. The Journal of clinical investigation. Vol. 101, no. 5: 1028-35.
Ryu, K, Y; Tong, Q; Jhiang, S M. 1998. Promoter characterization of the human Na+/I- symporter. The Journal of clinical endocrinology and metabolism. Vol. 83, no. 9: 3247-51.
Xing, S; Furminger, T, L; Tong, Q; Jhiang, S M. 1998. Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. The Journal of biological chemistry. Vol. 273, no. 9: 4909-14.
Castro, M, R; Bergert, E, R; Beito, T, G; Roche, P, C; Ziesmer, S, C; Jhiang, S, M; Goellner, J, R; Morris, J C. 1999. Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer. The Journal of endocrinology. Vol. 163, no. 3: 495-504.
Cho, J, Y; Sagartz, J, E; Capen, C, C; Mazzaferri, E, L; Jhiang, S M. 1999. Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. Oncogene. Vol. 18, no. 24: 3659-65.
Ryu, K, Y; Senokozlieff, M, E; Smanik, P, A; Wong, M, G; Siperstein, A, E; Duh, Q, Y; Clark, O, H; Mazzaferri, E, L; Jhiang, S M. 1999. Development of reverse transcription-competitive polymerase chain reaction method to quantitate the expression levels of human sodium iodide symporter. Thyroid : official journal of the American Thyroid Association. Vol. 9, no. 4: 405-9.
Cho, J, Y; Leveille, R; Kao, R; Rousset, B; Parlow, A, F; Burak, W E Jr; Mazzaferri, E, L; Jhiang, S M. 2000. Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands. The Journal of clinical endocrinology and metabolism. Vol. 85, no. 8: 2936-43.
Cho, J, Y; Xing, S; Liu, ; XBuckwalter, T, L; Hwa, L; Sferra, T, J; Chiu, I, M; Jhiang, S M. 2000. Expression and activity of human Na+/I- symporter in human glioma cells by adenovirus-mediated gene delivery. Gene therapy. Vol. 7, no. 9: 740-9.
Jen, C, J; Jhiang, S, J; Chen, H I. 2000. Invited review: effects of flow on vascular endothelial intracellular calcium signaling of rat aortas ex vivo. Journal of applied physiology. Vol. 89, no. 4: 1657-62; discussion 1656.
Jhiang, S M. 2000. A monoclonal antibody recognizing the extracellular domain of human Na+/I- symporter and its potential applications. The Journal of clinical endocrinology and metabolism. Vol. 85, no. 7: 2364-5.
Jhiang, S M. 2000. Regulation of sodium/iodide symporter. Reviews in endocrine & metabolic disorders. Vol. 1, no. 3: 205-15.
Jhiang, S M. 2000. The RET proto-oncogene in human cancers. Oncogene. Vol. 19, no. 49: 5590-7.
La Perle, K, M; Jhiang, S, M; Capen, C C. 2000. Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas. American journal of pathology. Vol. 157, no. 2: 671-7.
Rillema, J, A; Yu, T, ; XJhiang, S M. 2000. Effect of prolactin on sodium iodide symporter expression in mouse mammary gland explants. American journal of physiology. Endocrinology and metabolism. Vol. 279, no. 4: E769-72.
Shen DHY, Kloos RT, Mazzaferri EL, Jhiang SM. 2001. Invited Review: Sodium Iodide Symporter in Health and Disease. Thyroid. Vol. 11: 415-425.
Buckwalter, Tara L. F.; Venkateswaran, Anjli; Lavender, Marc; La Perle, Krista M. D.; Cho, Je-Yoel; Robinson, Michael L.; Jhiang, Sissy M. 2002. The roles of phosphotyrosines-294, -404, and -451 in Ret/ptc1-induced thyroid tumor formation. Oncogene. Vol. 21, no. 53: 8166-8172.
Cho, J-Y; Shen, D H, Y; Yang, W; Williams, B; Buckwalter, T L, F; La Perle, K M, D; Hinkle, G; Pozderac, R; Kloos, R; Nagaraja, H, N; Barth, R, F; Jhiang, S M. 2002. In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas. Gene therapy. Vol. 9, no. 17: 1139-45.
Kloos, Richard, T; Duvuuri, Vani; Jhiang, Sissy, M; Cahill, Kenneth, V; Foster, Jill, A; Burns, John A. 2002. Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma. The Journal of clinical endocrinology and metabolism. Vol. 87, no. 12: 5817-20.
La Perle, Krista M, D; Shen, Daniel; Buckwalter, Tara L, F; Williams, Bonnie; Haynam, Aaron; Hinkle, George; Pozderac, Rodney; Capen, Charles, C; Jhiang, Sissy M. 2002. In vivo expression and function of the sodium iodide symporter following gene transfer in the MATLyLu rat model of metastatic prostate cancer. The Prostate. Vol. 50, no. 3: 170-8.
Patel, Aneeta; Jhiang, Sissy; Dogra, Shalini; Terrell, Richard; Powers, Patricia, A; Fenton, Cydney; Dinauer, Catherine, A; Tuttle, R Michael; Francis, Gary L. 2002. Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents. Pediatric research. Vol. 52, no. 5: 737-44.
Aldred, M. A.; Huang, Y.; Liyanarachchi, S.; Pellegata, N. S.; Gimm, O.; Jhiang, S.; Davuluri, R.; de la Chapelle, A.; Eng, C. 2003. Six genes identified by comparative microarray analysis distinguish papillary from follicular thyroid carcinomas. American Journal of Human Genetics. Vol. 73, no. 5: 201.
Aldred, Micheala A.; Ginn-Pease, Margaret E.; Morrison, Carl D.; Popkie, Anthony P.; Gimm, Oliver; Hoang-Vu, Cuong; Krause, Ulf; Dralle, Henning; Jhiang, Sissy M.; Plass, Christoph; Eng, Charis. 2003. Caveolin-1 and caveolin-2, together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis. Cancer Research. Vol. 63, no. 11: 2864-2871.
Aldred, Micheala A.; Morrison, Carl; Gimm, Oliver; Hoang-Vu, Cuong; Krause, Ulf; Dralle, Henning; Jhiang, Sissy; Eng, Charis. 2003. Peroxisome proliferator-activated receptor gamma is frequently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas. Oncogene. Vol. 22, no. 22: 3412-3416.
Barton, Kenneth, N; Tyson, Donald; Stricker, Hans; Lew, Young, S; Heisey, Gregory; Koul, Sweaty; de la Zerda, Alberto; Yin, Fang-Fang; Yan, Hui; Nagaraja, Tavarekere, N; Randall, Kelly Ann; Jin, Guk Kim; Fenstermacher, Joseph, D; Jhiang, Sissy; Ho Kim, Jae; Freytag, Svend, O; Brown, Stephen L. 2003. GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. Vol. 8, no. 3: 508-18.
Fischer, Andrew H.; Taysavang, Panya; Jhiang, Sissy M. 2003. Nuclear envelope irregularity is induced by Ret/ptc during interphase. American Journal of Pathology. Vol. 163, no. 3: 1091-1100.
Fischer, Andrew, H; Taysavang, Panya; Jhiang, Sissy M. 2003. Nuclear envelope irregularity is induced by RET/PTC during interphase. American journal of pathology. Vol. 163, no. 3: 1091-100.
La Perle, Krista M, D; Blomme, Eric A, G; Capen, Charles, C; Jhiang, Sissy M. 2003. Effect of exogenous human sodium iodide symporter expression on growth of MATLyLu cells. Thyroid : official journal of the American Thyroid Association. Vol. 13, no. 2: 133-40.
Shen, D. H.; Marsee, D. K.; Yang, W.; Hinkle, G. H.; Nagaraja, H. N.; Kloos, R. T.; Barth, R. F.; Huang, W. S.; Jhiang, S. M. 2003. 188re-perrhenate treatment to enhance the survival of rats bearing intracerebral sodium-iodide symporter transduced gliomas. Journal of Nuclear Medicine. Vol. 44, no. 5 Supplement: 35P.
Aldred, Micheala, A; Huang, Ying; Liyanarachchi, Sandya; Pellegata, Natalia, S; Gimm, Oliver; Jhiang, Sissy; Davuluri, Ramana, V; de la Chapelle, Albert; Eng, Charis. 2004. Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Vol. 22, no. 17: 3531-9.
Burns, J, A; Morgenstern, K, E; Cahill, K, V; Foster, J, A; Jhiang, S, M; Kloos, R T. 2004. Nasolacrimal obstruction secondary to I(131) therapy. Ophthalmic plastic and reconstructive surgery. Vol. 20, no. 2: 126-9.
Knostman, Katherine A. B.; Cho, Je-Yoel; Ryu, Kwon-Yul; Lin, Xiaoqin; McCubrey, James A.; Hla, Timothy; Liu, Catherine H.; Di Carlo, Emma; Keri, Ruth; Zhang, Ming; Hwang, Dae Y.; Kisseberth, William C.; Capen, Charles C.; Jhiang, Sissy M. 2004. Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. Journal of Clinical Endocrinology & Metabolism. Vol. 89, no. 10: 5196-5203, 5189.
Lin, Xiaoqin; Fischer, Andrew H.; Ryu, Kwon-Yul; Cho, Je-Yoel; Sferra, Thomas J.; Kloos, Richard T.; Mazzaferri, Ernest L.; Jhiang, Sissy M. 2004. Application of the Cre/loxp system to enhance thyroid-targeted expression of sodium/iodide symporter. Journal of Clinical Endocrinology & Metabolism. Vol. 89, no. 5: 2344-2350.
Lin, Xiaoqin; Fischer, Andrew, H; Ryu, Kwon-Yul; Cho, Je-Yoel; Sferra, Thomas, J; Kloos, Richard, T; Mazzaferri, Ernest, L; Jhiang, Sissy M. 2004. Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporter. The Journal of clinical endocrinology and metabolism. Vol. 89, no. 5: 2344-50.
Lin, Xiaoqin; Ryu, Kwon-Yul; Jhiang, Sissy M. 2004. Cloning of the 5'-flanking region of mouse sodium/iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer. Thyroid : official journal of the American Thyroid Association. Vol. 14, no. 1: 19-27.
Marsee, Derek K.; Shen, Daniel H. Y.; MacDonald, Lawrence R.; Vadysirisack, Douangsone D.; Lin, Xiaoqin; Hinkle, George; Kloos, Richard T.; Jhiang, Sissy M. 2004. Imaging of metastatic pulmonary tumors following Nis gene transfer using single photon emission computed tomography. Cancer Gene Therapy. Vol. 11, no. 2: 121-127.
Marsee, Derek K.; Venkateswaran, Anjli; Tao, Haiyang; Vadysirisack, Douangsone; Zhang, Zhaoxia; Vandre, Dale D.; Jhiang, Sissy M. 2004. Inhibition of heat shock protein 90, a novel Ret/ptc1-associated protein, increases radioiodide accumulation in thyroid cells. Journal of Biological Chemistry. Vol. 279, no. 42: 43990-43997.
Miyagi, Eri; Braga-Basaria, Milena; Hardy, Elena; Vasko, Vasily; Burman, Kenneth, D; Jhiang, Sissy; Saji, Motoyasu; Ringel, Matthew D. 2004. Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells. Molecular carcinogenesis. Vol. 41, no. 2: 98-107.
Shen, D H, Y; Marsee, D, K; Schaap, J; Yang, W; Cho, J-Y; Hinkle, G; Nagaraja, H, N; Kloos, R, T; Barth, R, F; Jhiang, S M. 2004. Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy. Gene therapy. Vol. 11, no. 2: 161-9.
Shen, D. H. Y.; Marsee, D. K.; Schaap, J.; Yang, W.; Cho, J.-Y.; Hinkle, G.; Nagaraja, H. N.; Kloos, R. T.; Barth, R. F.; Jhiang, S. M. 2004. Effects of dose, intervention time, and radionuclide on sodium iodide symporter (nis)-targeted radionuclide therapy. Gene Therapy. Vol. 11, no. 2: 161-169.
Venkateswaran, Anjli; Marsee, Derek K.; Green, Steven H.; Jhiang, Sissy M. 2004. Forskolin, 8-br-3',5'-cyclic adenosine 5'-monophosphate, and catalytic protein kinase a expression in the nucleus increase radioiodide uptake and sodium/iodide symporter protein levels in Ret/ptc1-expressing cells. Journal of Clinical Endocrinology & Metabolism. Vol. 89, no. 12: 6168-6172.
Marsee, Derek, K; Vadysirisack, Douangsone, D; Morrison, Carl, D; Prasad, Manju, L; Eng, Charis; Duh, Quan-Yang; Rauen, Katherine, A; Kloos, Richard, T; Jhiang, Sissy M. 2005. Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral gene therapy. Thyroid : official journal of the American Thyroid Association. Vol. 15, no. 9: 977-87.
Morgenstern, Kenneth, E; Vadysirisack, Douangsone, D; Zhang, Zhaoxia; Cahill, Kenneth, V; Foster, Jill, A; Burns, John, A; Kloos, Richard, T; Jhiang, Sissy M. 2005. Expression of sodium iodide symporter in the lacrimal drainage system: implication for the mechanism underlying nasolacrimal duct obstruction in I(131)-treated patients. Ophthalmic plastic and reconstructive surgery. Vol. 21, no. 5: 337-44.
Zhang, Zhaoxia; Liu, Yu-Yu; Jhiang, Sissy M. 2005. Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/i- symporter and rat Na+/i- symporter. Journal of Clinical Endocrinology & Metabolism. Vol. 90, no. 11: 6131-6140.
Jeong Y, Jayanth GR, Jhiang S, Menq CH. 2006. Direct tip-sample interaction force control for the dynamic mode atomic force microscopy. Applied Physics Letters. Vol. 88, no. 20.
Sarquis, Marta S.; Weber, Frank; Shen, Lei; Broelsch, Christoph E.; Jhiang, Sissy M.; Zedenius, Jan; Frilling, Andrea; Eng, Charis. 2006. High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. Journal of Clinical Endocrinology & Metabolism. Vol. 91, no. 1: 262-269.
Vadysirisack, Douangsone D.; Shen, Daniel H.; Jhiang, Sissy M. 2006. Correlation of Na+/i- symporter expression and activity: Implications of Na+/i- symporter as an imaging reporter gene. Journal of Nuclear Medicine. Vol. 47, no. 1: 182-190.
Knostman KA, Jhiang SM, Capen CC. 2007. Genetic alterations in thyroid cancer: the role of mouse models. Vet Pathol. Vol. 44: 1-14. (IF: 1.188)
Vadysirisack DD, Venkateswaran A, Zhang Z, Jhiang SM. 2007. MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner. Endocrine Related Cancer. Vol. 14: 421-432. (IF: 4.763)
Knostman KA; McCubrey JA; Morrison CD; Zhang Z; Capen CC; Jhiang SM. 2007. PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer. BMC Cancer. Vol. 7. (January 1): 137.
Knostman KA; Venkateswaran A; Zimmerman B; Capen CC; Jhiang SM. 2007. Creation and characterization of a doxycycline-inducible mouse model of thyroid-targeted RET/PTC1 oncogene and luciferase reporter gene coexpression. Thyroid: Official Journal Of The American Thyroid Association. Vol. 17, no. 12. (December 1): 1181.
Vadysirisack DD; Chen ES; Zhang Z; Tsai MD; Chang GD; Jhiang SM. 2007. Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter. The Journal Of Biological Chemistry. Vol. 282, no. 51. (December 21): 36820.
Jayanth GR; Jhiang SM; Menq CH. 2008. Two-axis probing system for atomic force microscopy. The Review Of Scientific Instruments. Vol. 79, no. 2 Pt 1. (February 1): 023705.
Positions
| 1987 - 1988 | Postdoctoral Research Associate, University of Texas, The University of Texas at Austin, Zoology. Austin, TX, United States. |
| 1988 - 1989 | Instructor, Baylor College of Medicine, Pharmacology. Houston, TX, United States. |
| 1990 - 1991 | Research Specialist, The Ohio State University, Internal Medicine. Columbus, OH, United States. |
| 1991 - 1997 | Assistant Professor, The Ohio State University, Internal Medicine. Columbus, OH, United States. |
| 1991 - present | Graduate Faculty Member, The Ohio State University, Ohio State Biochemistry Graduate Program; Molecular, Cellular and Developmental Graduate Program; Veterinary Biosciences Graduate Program; Integrated Biomedical Science Graduate Program. Columbus, OH, United States. |
| 1991 - present | Member, The Ohio State University, Comprehensive Cancer Center. Columbus, OH, United States. |
| 1993 - 1997 | Assistant Professor, The Ohio State University, Physiology. Columbus, OH, United States. |
| 1997 - 2003 | Associate Professor, The Ohio State University, Physiology and Cell Biology; Internal Medicine. Columbus, OH, United States. |
| 1999 - 2001 | Co-Director, The Ohio State University, MD/PhD Training Program. Columbus, OH, United States. |
| 2003 - present | Professor, The Ohio State University, College of Medicine, School of Biomedical Sciences, Physiology and Cell Biology. Columbus, OH, United States. |
Presentations
Other Presentations
Local
Dr Sissy Meihua Jhiang. 1992. Oncogenes in Thyroid Cancer. Presented at Department of Biological Sciences, Duequene University. Pittsburgh, PA. (February 21)
Dr Sissy Meihua Jhiang. 1993. Clinical and Molecular Study of the Thyroid-Specific PTC/ret Oncogene. Presented at Department of Endocrinology & Metabolism, Chang-Gung Medical College. Taoyan, Taiwan. (July 19)
Dr Sissy Meihua Jhiang. 1993. Clinical and Molecular Study of the Thyroid-Specific PTC/ret Oncogene. Presented at Department of Internal Medicine, National Taiwan University Hospital. Taipei, Taiwan. (July 26)
Dr Sissy Meihua Jhiang. 1993. Molecular Defects Underlying the Loss of Iodine Concentrating Activity in Malignant Thyroid Tumors. Presented at Department of Nuclear Medicine, Veterans General Hospital. Taipei, Taiwan. (July 27)
Dr Sissy Meihua Jhiang. 1994. PTC Oncogene in Papillary Thyroid Carcinoma. Presented at Mount Zion Medical Center. San Francisco, CA. (April 8)
Dr Sissy Meihua Jhiang. 1995. Mechanistic study of various RET oncogenic activations in human cancers. Presented at The 2nd International Meeting: Hirschsprung Disease and Related Neurocristopathies. Case Western Reserve University, Cleveland, OH. (October 22)
Dr Sissy Meihua Jhiang. 1995. One gene for five disease: the RET proto-oncogene. Presented at Medical Research Laboratory, Veteran General Hospital. Taipei, Taiwan. (December 5)
Dr Sissy Meihua Jhiang. 1995. One gene for five disease: the RET proto-oncogene. Presented at Department of Biochemistry, College of Medicine, National Taiwan University. Taipei, Taiwan. (December 6)
Dr Sissy Meihua Jhiang. 1995. Clinical applications of RET mutations in thyroid cancers. Presented at Division of Endocrinology and Metabolism, Chang-Gung Memorial Hospital. Linko, Taiwan. (December 7)
Dr Sissy Meihua Jhiang. 1996. RET Oncogene. Presented at The 69th Annual Meeting of the American Thyroid Association. San Diego, CA. (November 16)
Dr Sissy Meihua Jhiang. 1997. RET Mutation Analysis in Medullary Thyroid Carcinomas. Presented at Toronto Thyroid Club. Toronto, Canada. (April 10)
Dr Sissy Meihua Jhiang. 1997. RET/PTC1 Transgenic Mouse Model for Induction of Papillary Thyroid Carcinoma. Presented at Samuel Lunenfeld Research Institute, Mount Sinai Hospital. Toronto, Canada. (April 10)
Dr Sissy Meihua Jhiang. 1997. Clinical Perspectives of RET Oncogene and Thyroid Iodide Transporter in Thyroid Cancers. Presented at Citywide Endocrine Round. Toronto, Canada. (April 11)
Dr Sissy Meihua Jhiang. 1997. RET Oncogene in Human Cancers. Presented at Institute of Molecular Biology, Academia Sinica. Taiwan. (June 30)
Dr Sissy Meihua Jhiang. 1997. Clinical Perspectives of Na/I Symporter in Human Cancers. Presented at Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital. Linko, Taiwan. (July 4)
Dr Sissy Meihua Jhiang. 1997. Clinical Perspectives of RET Oncogene and Na/I Symporter in Thyroid Cancers. Presented at Liver Club, Medical Research Laboratory, Veteran General Hospital. Taipei, Taiwan. (July 7)
Dr Sissy Meihua Jhiang. 1997. Thyroid Carcinomas in RET/PTC Transgenic Mice. Presented at Dr. Mildred Scheel Stiftung, XI International Meeting, "Genes and Environment in Cancers". Bonn, Germany. (November 18)
Dr Sissy Meihua Jhiang. 1998. Thyroid Carcinomas in RET/PTC Transgenic Mice. Presented at Hormone and Cancer Research Conference, University of Colorado Health Science Center. Denver, CO. (March 10)
Dr Sissy Meihua Jhiang. 1998. Clinical Perspectives of Na+/I- Symporter in Human Cancers. Presented at Endocrine Grand Rounds, University of Colorado Health Science Center. Denver, CO. (March 11)
Dr Sissy Meihua Jhiang. 1998. The RET Proto-Oncogene in Human Diseases. Presented at Cellular and Molecular Biology Seminar, The Unversity of Texas at Austin. Austin, TX. (April 21)
Dr Sissy Meihua Jhiang. 1998. The Iodide Transporter. Presented at ENDO '98, the 80th Annual Meeting of the Endocrine Society. New Orleans, LA. (June 24)
Dr Sissy Meihua Jhiang. 1998. Regulation of Thyroid Iodide Transporter. Presented at The 71st Annual Meeting of the American Thyroid Association. Portland, OR. (September 17)
Dr Sissy Meihua Jhiang. 1998. Molecular Study of the Human Na+/I- Symporter. Presented at The 13th Annual Meeting of the Ohio Physiological Society. Wright State University, Dayton, OH. (November 12)
Dr Sissy Meihua Jhiang. 1998. Thyroid cancrinomas in RET/PTC transgenic mice; Clinical perspectives of the Na+/I- symporter in human cancers. Presented at International Symposium on Recent Advances in Pancreas and Islet Transplantation and Thyroid Cancer. Chang Gung Memorial Hospital, Taiwan. (December 6)
Dr Sissy Meihua Jhiang. 1998. RET Oncogene in Human Disease. Presented at Graduate Institute of Clinical Medicine, Kaohsiung Division, Chang Gung University. Taiwan. (December 7)
Dr Sissy Meihua Jhiang. 1998. Clinical Perspective of the Na+/I- Symporter in Human Cancers. Presented at Chang Gung Memorial Hospital. Kaohsiung, Taiwan. (December 8)
Dr Sissy Meihua Jhiang. 1999. Thyroid carcinomas in RET/PTC transgenic mice; Clinical perspectives of the Na+/I- symporter in human cancers. Presented at The 8th Latin American Thyroid Congress. Iguassu Falls, Parana, Brazil. (May 26)
Dr Sissy Meihua Jhiang. 1999. Gene transfer of sodium iodide symporter for radioiodide therapy in human cancer. Presented at The Cleveland Clinic/OSU 2nd Scientific Symposium. Cleveland, OH. (June 5)
Dr Sissy Meihua Jhiang. 1999. RET/PTC transgenic mouse. Presented at The 72nd Annual Meeting of the American Thyroid Association. Palm Beach, FL. (September 30)
Dr Sissy Meihua Jhiang. 1999. Clinical application of Na+/I- symporter. Presented at CDA/CSEM Professional Conference and Annual Meeting. Ottawa, Canada. (October 16)
Dr Sissy Meihua Jhiang. 2000. The Na+/I- Symporter: Molecular Basis for Radioiodine Therapy. Presented at Endocrine Seminar, The Mount Sinai Hospital. New York, NY. (February 3)
Dr Sissy Meihua Jhiang. 2000. The Na+/I- Symporter: Molecular Basis for Radioiodine Therapy. Presented at Endocrine Grand Rounds, National Institutes of Health. Bethesda, DC. (March 10)
Dr Sissy Meihua Jhiang (Given by Dr. Je-Yoel Cho). 2000. Na+/I- Symporter Gene Transfer and Cancer Therapy. Presented at 11th International Congress of Endocrinology. Sydney, Australia. (November 2)
Dr Sissy Meihua Jhiang. 2001. RET/PTC1 Induced Signaling in Thyroid Tumorigenesis. Presented at ENDO '01, the 83rd Annual Meeting of the Endocrine Society. Denver, CO. (June 20)
Dr Sissy Meihua Jhiang. 2001. Thyroid Cancers: Genetics and Gene Therapy. Presented at The Second International Huaxia Congress of Endocrinology. Hong Kong SAR, China. (December 16)
Dr Sissy Meihua Jhiang. 2002. A Dual Role for NIS in Cancer Gene Therapy: Imaging and Treatment. Presented at The International MEN Workshop. Grandpit, MI. (June 17)
Dr Sissy Meihua Jhiang. 2002. NIS as an IMAGENE for Gene Therapy. Presented at The 12th Asia-Oceania Congress of Endocrinology. Taipei, Taiwan. (September 22)
Dr Sissy Meihua Jhiang. 2002. Meet the Professor Luncheons, Strategies to Develop Novel Treatment for Patients with Advanced Thyroid Cancer. Presented at The 74th Annual Meeting of the American Thyroid Association. Los Angeles, CA. (October 10)
Dr Sissy Meihua Jhiang. 2002. Van Meter Award Lecture, Lessons from Thyroid Cancer: Genetics and Gene Therapy. Presented at The 74th Annual Meeting of the American Thyroid Association. Los Angeles, CA. (October 11)
Dr Sissy Meihua Jhiang. 2003. The Sodium-Iodide Symporter as a Therapeutic Tool in Thyroid and Non-Thyroid Malignancies. Presented at FASEB 2003 - cancelled due to illness. San Diego, CA. (April 14)
Dr Sissy Meihua Jhiang. 2003. Lessons from Thyroid Cancer: Genetics and Gene Therapy. Presented at CAS '2003 Molecular Biology and Genetic Engineering Seminar Series. Columbus, OH. (April 24)
Dr Sissy Meihua Jhiang. 2003. Lessons from Thyroid Cancer: Genetics and Gene Therapy. Presented at The 24th American Association of Endocrine Surgeons Annual Meeting. San Diego, CA. (May 12)
Dr Sissy Meihua Jhiang. 2003. Lessons from Thyroid Cancer: Genetics and Gene Therapy. Presented at Endocrine Guest Lecture, University of Massachusetts Medical School. Worcester, MA. (May 27)
Dr Sissy Meihua Jhiang. 2004. NIS in Thyroid Cancer and Its Clinical Application. Presented at The 9th Asian Association of Endocrine Surgeons Annual Meeting. Taipei, Taiwan. (March 4)
Dr Sissy Meihua Jhiang. 2004. The Sodium-Iodide Symporter as an Imaging and Therapeutic Tool in Thyroid and NOn-Thyroid Malignancies. Presented at Endocrine Grand Rounds, Northwestern University. Chicago, IL. (September 2)
Dr Sissy Meihua Jhiang. 2004. NIS in thyroid cancer and Gene Therapy. Presented at Ernest L Mazzaferri Thyroid Cancer Conference: Thyroid cancer from predisposition to therapy, a bench to bedside symposium. The Ohio State University, Columbus, OH. (November 5)
Dr Sissy Meihua Jhiang. 2005. NIS in Thyroid Cancer and Gene Therapy. Presented at 13th International Thyroid Congress. Buenos Aires, Argentina. (October 30)
Dr Sissy Meihua Jhiang. 2005. RET/PTC1 Thyroid Tumorigenesis and NIS-mediated Radionuclide Imaging and Therapy. Presented at Department of Surgery, University of California at San Francisco. San Francisco, CA. (November 22)
Dr Sissy Meihua Jhiang. 2006. An update on NIS-mediated radionuclide imaging and therapy in human cancer. Presented at Cancer research group, Tri-Service General Hospital. Taipei, Taiwan. (March 14)
Dr Sissy Meihua Jhiang. 2006. NIS-mediated radionuclide imaging. Presented at Department of Nuclear Medicine, Tri-Service General Hospital. Taipei, Taiwan. (March 16)
Dr Sissy Meihua Jhiang. 2006. An update on NIS-mediated radionuclide imaging and therapy in human cancer. Presented at The 27th Annual Meeting of the Endocrine Society and the Diabetes Association of the R.O.C. Taipei, Taiwan. (March 23)
Dr Sissy Meihua Jhiang. 2006. NIS targeted radionuclide imaging and therapy in human cancer. Presented at Institute of Cellular and Organismic Biology, Academia Sinica. Taipei, Taiwan. (March 25)
Dr Sissy Meihua Jhiang. 2006. RET signaling in thyroid tumorigenesis and NIS-mediated imaging and therapy. Presented at Veteran General Hospital. Taipei, Taiwan. (March 28)