Current OSU Appointments

Associate Professor, Physiology and Cell Biology

Associate Professor, Cardiovascular Medicine

Degrees

1994	M.S., Utrecht University, Medical Biology

1997	Ph.D., Utrecht University, Cardiac Physiology

Editor Reviewed Journal Articles

Periasamy M, Janssen PML. 2008. Molecular basis of diastolic dysfunction. Heart Failure Clinics..

Editorial Activities

Ad Hoc Reviewer

Honors

1991	Medical Biology Student Society. MBV Mebiose.

1992	Netherlands Heart Foundation Travel Award. Netherlands Heart Foundation.

1993 - 1994

VSB Scholarship Award. Verenigde Spaarbank.

1998	Sagawa Young Investigator Award. Cardiovascular System Dynamics Society.

2002	Best Poster Award. XVth Meeting of the CSDS.

2004 - 2007

Secretary Treasurer. Cardiovascular System Dynamics Society.

2007	Established Investigator Award.

Memberships

1994 - present

Member. American Physiological Society

1994 - present

Member. Biophysical Society

1998 - present

Member. Cardiovascular System Dynamics Society

1999 - present

Member. American Heart Association

2000 - present

Member. International Society for Heart Research

2000 - present

Member. Cardiac Muscle Society

2000 - present

Member. European Muscle Club

Peer Reviewed Journal Articles

Janssen, P, M; Hunter, W C. 1995. Force, not sarcomere length, correlates with prolongation of isosarcometric contraction. The American journal of physiology. Vol. 269, no. 2 Pt 2: H676-85.

Van Bergen, P; Janssen, P, M; Hoogerhout, P; De Wildt, D, J; Versteeg, D H. 1995. Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship. European journal of pharmacology. Vol. 294, no. 2-3: 795-803.

Janssen, P, M; Honda, H; Koiwa, Y; Shirato, K. 1996. The effect of diastolic vibration on the relaxation of rat papillary muscle. Cardiovascular research. Vol. 32, no. 2: 344-50.

Janssen, P, M; de Tombe, P P. 1997. Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae. The American journal of physiology. Vol. 273, no. 5 Pt 2: H2415-22.

Janssen, P, M; de Tombe, P P. 1997. Uncontrolled sarcomere shortening increases intracellular Ca2+ transient in rat cardiac trabeculae. The American journal of physiology. Vol. 272, no. 4 Pt 2: H1892-7.

Janssen, P, M; Schiereck, P; Honda, H; Naya, T; Koiwa, Y. 1997. The effect of applied mechanical vibration on two different phases of rat papillary muscle relaxation. Pflugers Archiv : European journal of physiology. Vol. 434, no. 6: 795-800.

Wannenburg, T; Janssen, P, M; Fan, D; de Tombe, P P. 1997. The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment. The American journal of physiology. Vol. 273, no. 5 Pt 2: H2428-35.

Janssen, P, M; Lehnart, S, E; Prestle, J; Lynker, J, C; Salfeld, P; Just, H; Hasenfuss, G. 1998. The trabecula culture system: a novel technique to study contractile parameters over a multiday time period. The American journal of physiology. Vol. 274, no. 5 Pt 2: H1481-8.

Schiereck, P; van Heijst, B, G; Jansen, P, M; Schiereck, J; van der Leun, M; Bras, W; de Beer, E L. 1998. Force generation and shift of mass between myosin and actin in skinned striated muscle fibres at low calcium concentrations. European biophysics journal : EBJ. Vol. 27, no. 6: 575-81.

Janssen, P, M; Lehnart, S, E; Prestle, J; Hasenfuss, G. 1999. Preservation of contractile characteristics of human myocardium in multi-day cell culture. Journal of molecular and cellular cardiology. Vol. 31, no. 8: 1419-27.

Janssen, P, M; Zeitz, O; Hasenfuss, G. 1999. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol. European journal of pharmacology. Vol. 366, no. 2-3: 223-32.

Hermann, H, P; Zeitz, O; Keweloh, B; Hasenfuss, G; Janssen, P M. 2000. Pyruvate potentiates inotropic effects of isoproterenol and Ca(2+) in rabbit cardiac muscle preparations. American journal of physiology. Heart and circulatory physiology. Vol. 279, no. 2: H702-8.

Janssen, P, M; Datz, N; Zeitz, O; Hasenfuss, G. 2000. Levosimendan improves diastolic and systolic function in failing human myocardium. European journal of pharmacology. Vol. 404, no. 1-2: 191-9.

Janssen, P, M; Zeitz, O; Keweloh, B; Siegel, U; Maier, L, S; Barckhausen, P; Pieske, B; Prestle, J; Lehnart, S, E; Hasenfuss, G. 2000. Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium. Cardiovascular research. Vol. 47, no. 1: 99-107.

Lehnart, S, E; Janssen, P, M; Franz, W, M; Donahue, J, K; Lawrence, J, H; Marban, E; Prestle, J; Hasenfuss, G. 2000. Preservation of myocardial function after adenoviral gene transfer in isolated myocardium. American journal of physiology. Heart and circulatory physiology. Vol. 279, no. 3: H986-91.

Schillinger, W; Janssen, P, M; Emami, S; Henderson, S, A; Ross, R, S; Teucher, N; Zeitz, O; Philipson, K, D; Prestle, J; Hasenfuss, G. 2000. Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger. Circulation research. Vol. 87, no. 7: 581-7.

Tanaka, Y; Guhde, G; Suter, A; Eskelinen, E, L; Hartmann, D; Lullmann-Rauch, R; Janssen, P, M; Blanz, J; von Figura, K; Saftig, P. 2000. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature. Vol. 406, no. 6798: 902-6.

Wannenburg, T; Heijne, G, H; Geerdink, J, H; Van Den Dool, H, W; Janssen, P, M; De Tombe, P P. 2000. Cross-bridge kinetics in rat myocardium: effect of sarcomere length and calcium activation. American journal of physiology. Heart and circulatory physiology. Vol. 279, no. 2: H779-90.

Zeitz, O; Rahman, A; Hasenfuss, G; Janssen, P M. 2000. Impact of beta-adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardium. Journal of cardiovascular pharmacology. Vol. 36, no. 1: 126-31.

Baudet, S; Weisser, J; Janssen, A, P; Beulich, K; Bieligk, U; Pieske, B; Noireaud, J; Janssen, P, M; Hasenfuss, G; Prestle, J. 2001. Increased basal contractility of cardiomyocytes overexpressing protein kinase C epsilon and blunted positive inotropic response to endothelin-1. Cardiovascular research. Vol. 50, no. 3: 486-94.

Janssen, P, M; Zeitz, O; Rahman, A; Hasenfuss, G. 2001. Protective role of nebivolol in hydroxyl radical induced injury. Journal of cardiovascular pharmacology. Vol. 38 Suppl 3: S17-23.

Milting, H; Janssen, P, M; Wangemann, T; Kogler, H; Domeier, E; Seidler, T; Hakim, K; Grapow, M; Zeitz, O; Prestle, J; Zerkowski, H R. 2001. FK506 does not affect cardiac contractility and adrenergic response in vitro. European journal of pharmacology. Vol. 430, no. 2-3: 299-304.

Most, P; Bernotat, J; Ehlermann, P; Pleger, S, T; Reppel, M; Borries, M; Niroomand, F; Pieske, B; Janssen, P, M; Eschenhagen, T; Karczewski, P; Smith, G, L; Koch, W, J; Katus, H, A; Remppis, A. 2001. S100A1: a regulator of myocardial contractility. Proceedings of the National Academy of Sciences of the United States of America. Vol. 98, no. 24: 13889-94.

Prestle, J; Janssen, P, M; Janssen, A, P; Zeitz, O; Lehnart, S, E; Bruce, L; Smith, G, L; Hasenfuss, G. 2001. Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility. Circulation research. Vol. 88, no. 2: 188-94.

Hasenfuss, Gerd; Maier, Lars, S; Hermann, Hans-Peter; Luers, Claus; Hunlich, Mark; Zeitz, Oliver; Janssen, Paul M, L; Pieske, Burkert. 2002. Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium. Circulation. Vol. 105, no. 2: 194-9.

Hermann, Hans Peter; Zeitz, Oliver; Lehnart, Stephan, E; Keweloh, Boris; Datz, Nicolin; Hasenfuss, Gerd; Janssen, Paul M L. 2002. Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium. Cardiovascular research. Vol. 53, no. 1: 116-23.

Janssen, P M, L; Hasenfuss, G; Zeitz, O; Lehnart, S, E; Prestle, J; Darmer, D; Holtz, J; Schumann, H. 2002. Load-dependent induction of apoptosis in multicellular myocardial preparations. American journal of physiology. Heart and circulatory physiology. Vol. 282, no. 1: H349-56.

Janssen, Paul M, L; Schillinger, Wolfgang; Donahue, J Kevin; Zeitz, Oliver; Emami, Shahriyar; Lehnart, Stephan, E; Weil, Joachim; Eschenhagen, Thomas; Hasenfuss, Gerd; Prestle, Juergen. 2002. Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium. Cardiovascular research. Vol. 55, no. 2: 300-8.

Janssen, Paul M, L; Stull, Linda, B; Marban, Eduardo. 2002. Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat. American journal of physiology. Heart and circulatory physiology. Vol. 282, no. 2: H499-507.

Stull, Linda, B; Leppo, Michelle, K; Marban, Eduardo; Janssen, Paul M L. 2002. Physiological determinants of contractile force generation and calcium handling in mouse myocardium. Journal of molecular and cellular cardiology. Vol. 34, no. 10: 1367-76.

Zeitz, Oliver; Maass, A Eveline; Van Nguyen, Phuc; Hensmann, Geerd; Kogler, Harald; Moller, Karsten; Hasenfuss, Gerd; Janssen, Paul M L. 2002. Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange. Circulation research. Vol. 90, no. 9: 988-95.

Janssen, Paul M, L; Stull, Linda, B; Leppo, Michelle, K; Altschuld, Ruth, A; Marban, Eduardo. 2003. Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat. American journal of physiology. Heart and circulatory physiology. Vol. 284, no. 3: H772-8.

Schillinger, W; Ohler, A; Emami, S; Muller, F; Christians, C; Janssen, P M, L; Kogler, H; Teucher, N; Pieske, B; Seidler, T; Hasenfuss, G. 2003. The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPase. Cardiovascular research. Vol. 57, no. 4: 996-1003.

van der Velden, J; Papp, Z; Boontje, N, M; Zaremba, R; de Jong, J, W; Janssen, P M, L; Hasenfuss, G; Stienen, G J M. 2003. Myosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium. Advances in experimental medicine and biology. Vol. 538: 3-15.

van der Velden, J; Papp, Z; Boontje, N, M; Zaremba, R; de Jong, J, W; Janssen, P M, L; Hasenfuss, G; Stienen, G J M. 2003. The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts. Cardiovascular research. Vol. 57, no. 2: 505-14.

Hermann, Hans-Peter; Arp, Jordis; Pieske, Burkert; Kogler, Harald; Baron, Steffen; Janssen, Paul M, L; Hasenfuss, Gerd. 2004. Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure. European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology. Vol. 6, no. 2: 213-8.

Most, Patrick; Pleger, Sven, T; Volkers, Mirko; Heidt, Beatrix; Boerries, Melanie; Weichenhan, Dieter; Loffler, Eva; Janssen, Paul M, L; Eckhart, Andrea, D; Martini, Jeffrey; Williams, Matthew, L; Katus, Hugo, A; Remppis, Andrew; Koch, Walter J. 2004. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. The Journal of clinical investigation. Vol. 114, no. 11: 1550-63.

Palmer, Bradley, M; Georgakopoulos, Dimitrios; Janssen, Paul, M; Wang, Yuan; Alpert, Norman, R; Belardi, Diego, F; Harris, Samantha, P; Moss, Richard, L; Burgon, Patrick, G; Seidman, Christine, E; Seidman, J, G; Maughan, David, W; Kass, David A. 2004. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circulation research. Vol. 94, no. 9: 1249-55.

Rossman, Eric, I; Petre, Rebecca, E; Chaudhary, Khuram, W; Piacentino, Valentino 3rd; Janssen, Paul M, L; Gaughan, John, P; Houser, Steven, R; Margulies, Kenneth B. 2004. Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium. Journal of molecular and cellular cardiology. Vol. 36, no. 1: 33-42.

Takimoto, Eiki; Soergel, David, G; Janssen, Paul M, L; Stull, Linda, B; Kass, David, A; Murphy, Anne M. 2004. Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites. Circulation research. Vol. 94, no. 4: 496-504.

Babu, Gopal, J; Zheng, Zhaolun; Natarajan, Poornima; Wheeler, Debra; Janssen, Paul, M; Periasamy, Muthu. 2005. Overexpression of sarcolipin decreases myocyte contractility and calcium transient. Cardiovascular research. Vol. 65, no. 1: 177-86.

Janssen, Paul M, L; Hiranandani, Nitisha; Mays, Tessily, A; Rafael-Fortney, Jill A. 2005. Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice. American journal of physiology. Heart and circulatory physiology. Vol. 289, no. 6: H2373-8.

Weisser-Thomas, J; Dieterich, E; Janssen, P M, L; Schmidt-Schweda, S; Maier, L, S; Sumbilla, C; Pieske, B. 2005. Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes. Journal of pharmacological and toxicological methods. Vol. 51, no. 2: 91-103.

Babu, Gopal, J; Bhupathy, Poornima; Petrashevskaya, Natalia, N; Wang, Honglan; Raman, Sripriya; Wheeler, Debra; Jagatheesan, Ganapathy; Wieczorek, David; Schwartz, Arnold; Janssen, Paul M, L; Ziolo, Mark, T; Periasamy, Muthu. 2006. Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. The Journal of biological chemistry. Vol. 281, no. 7: 3972-9.

Hiranandani, Nitisha; Bupha-Intr, Tepmanas; Janssen, Paul M L. 2006. SERCA overexpression reduces hydroxyl radical injury in murine myocardium. American journal of physiology. Heart and circulatory physiology. Vol. 291, no. 6: H3130-5.

Hiranandani, Nitisha; Varian, Kenneth, D; Monasky, Michelle, M; Janssen, Paul M L. 2006. Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions. Journal of applied physiology. Vol. 100, no. 5: 1727-32.

Raman, Sripriya; Kelley, Melissa, A; Janssen, Paul M L. 2006. Effect of muscle dimensions on trabecular contractile performance under physiological conditions. Pflugers Archiv : European journal of physiology. Vol. 451, no. 5: 625-30.

Stull, Linda, B; Hiranandani, Nitisha; Kelley, Missy, A; Leppo, Missy, K; Marban, Eduardo; Janssen, Paul M L. 2006. Murine strain differences in contractile function are temperature- and frequency-dependent. Pflugers Archiv : European journal of physiology. Vol. 452, no. 2: 140-5.

Stypmann, Jorg; Janssen, Paul M, L; Prestle, Jurgen; Engelen, Markus, A; Kogler, Harald; Lullmann-Rauch, Renate; Eckardt, Lars; von Figura, Kurt; Landgrebe, Jobst; Mleczko, Anna; Saftig, Paul. 2006. LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling. Basic research in cardiology. Vol. 101, no. 4: 281-91.

Varian, Kenneth, D; Raman, Sripriya; Janssen, Paul M L. 2006. Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae. American journal of physiology. Heart and circulatory physiology. Vol. 290, no. 5: H2092-7.

Acharyya, Swarnali; Villalta, S Armando; Bakkar, Nadine; Bupha-Intr, Tepmanas; Janssen, Paul M, L; Carathers, Micheal; Li, Zhi-Wei; Beg, Amer, A; Ghosh, Sankar; Sahenk, Zarife; Weinstein, Michael; Gardner, Katherine, L; Rafael-Fortney, Jill, A; Karin, Michael; Tidball, James, G; Baldwin, Albert, S; Guttridge, Denis C. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. The Journal of clinical investigation. Vol. 117, no. 4: 889-901. (IF: 15.754)

Bupha-Intr T, Holmes JW, Janssen PML. 2007. Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium. Am J. Physiol. Heart Circ. Physiol.. Vol. 293: H3759-H3767.

Carnes, Cynthia, A; Janssen, Paul M, L; Ruehr, Mary, L; Nakayama, Hitomi; Nakayama, Tomohiro; Haase, Hannelore; Bauer, John Anthony; Chung, Mina, K; Fearon, Ian, M; Gillinov, A Marc; Hamlin, Robert, L; Van Wagoner, David R. 2007. Atrial glutathione content, calcium current, and contractility. The Journal of biological chemistry. Vol. 282, no. 38: 28063-28073.

Guterl KA, Haggart CR, Janssen PML, Holmes JW. 2007. Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles. Am J. Physiol. Heart Circ. Physiol.. Vol. 293: H3707-H3712.

Janssen PML, Periasamy M. 2007. Determinants of Frequency Dependent Contraction and Relaxation of Mammalian Myocardium. J Mol Cell Cardiol.. Vol. 43: 523-531.

Rodino-Klapac LR, Janssen PML, Montgomery CL, Coley BD, Chicoine LG, Clark KR, Mendell JR. 2007. A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure treatment. J. Translational Medicine. Vol. 5: 45.

Varian, Kenneth, D; Janssen, Paul M L. 2007. Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity. American journal of physiology. Heart and circulatory physiology. Vol. 292, no. 5: H2212-9.

Hiranandani N, Raman S, Kalyanasunaram A, Periasamy M, Janssen PML. 2007. Frequency-dependent contractile strength in mice over- and under-expressing the sarcoplasmic reticulum calcium ATPase. Am J Physiol Reg Integr Comp Physiol.. Vol. 293. (January): R30-R36.

Monasky MM, Varian KD, Janssen PML. 2008. Gender comparison of contractile performance and beta-adrenergic response in isolated rat cardiac trabeculae. J. Comp. Physiol. Biochem.. Vol. 178: 307-313. (IF: 2.029)

Torres CAA, Varian KD, Janssen PML. Variability in interbeat duration influences myocardial contractility in rat cardiac trabeculae. Open Cardiovascular Medicine Journal. (In press)

Periasamy M, Janssen PM. 2008. Molecular basis of diastolic dysfunction. Heart Fail Clin. Vol. 4, no. 1. (January): 13-21.

Monasky MM, Varian KD, Davis JP, Janssen PML. 2008. Dissociation of Force Decline from Calcium Decline by Preload in Isolated Rabbit Myocardium. Eur J Physiol.. Vol. 456, no. May;456(2):267-76. (May): 267-76.

Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PM, Ziolo MT. 2008. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. Am J Physiol Cell Physiol. Vol. 294, no. 6. (June): C1566-75. (IF: 4.230)

Mays TA, Binkley PF, Lesinski A, Doshi AA, Quaile MP, Margulies KB, Janssen PM, Rafael-Fortney JA. 2008. Claudin-5 levels are reduced in human end-stage cardiomyopathy. J Mol Cell Cardiol. Vol. 45, no. 1. (July): 81-7. (IF: 5.246)

Sanford JL, Mays TA, Varian KD, Wilson JB, Janssen PM, Rafael-Fortney JA. 2008. Truncated CASK does not alter skeletal muscle or protein interactors. Muscle Nerve. Vol. 38, no. 3. (September): 1116-27. (IF: 2.424)

Positions

1991 - 1992

M.S. Student, Univ. Utrecht, Utrecht, NL, Department of Medical Physiology and Sportsmedicine. Utrecht, NL.

1991 - 1992

M.S. Student, Daresbury, U.K, Synchrotron Radiation Source. Daresbury, U.K.

1992 - 1993

M.S. Student, Univ. Utrecht, Utrecht, NL, Rudolf Magnus Institute for Pharmacology. Univ. Utrecht, Utrecht, NL.

1993 - 1994

Research Trainee, Johns Hopkins University, School of Medicine, Biomedical Engineering. Baltimore, MD, United States.

1994 - 1996

Ph.D. Student, Bowman Gray School of Medicine, Wake Forest University, Internal Medicine, Section of Cardiology. Winston-Salem, NC, United States.

1994	Visiting Scientist, Tohoku University, Medicine, First Department of Internal Medicine. Sendai, Japan.

1996 - 1997

Ph.D. Student, University of Illinois at Chicago, Physiology and Biophysics. Chicago, IL, United States.

1997 - 1998

Post-Doc, University of Freiburg, Medicine, Cardiology. Germany.

1998 - 2000

Post-Doc, Gottingen University, Medicine, Cardiology. Gottingen, Germany.

2000 - 2002

Research Associate, Johns Hopkins University, School of Medicine, Internal Medicine, Division of Cardiology, Institute of Molecular Cardiobiology. Baltimore, MD, United States.

2002 - 2008

Assistant Professor, The Ohio State University, College of Medicine, School of Biomedical Sciences, Physiology and Cell Biology. Columbus, OH, United States.

2008 - present

Associate Professor, The Ohio State University, College of Medicine, School of Biomedical Sciences, Physiology and Cell Biology. Columbus, OH, United States.

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