OSU:pro

Current OSU Appointment

Associate Professor, Microbiology Administration

Books and Monographs

Ibba, M., Francklyn, C. and Cusack, S., Editors. 2005. The Aminoacyl-tRNA Synthetases. Georgetown, Texas, USA: Landes Bioscience.

Degrees

1986	B.S., Imperial College of Science & Technology, London University, Biochemistry

1990	Ph.D., University of Manchester

Editorial Activities

Editorial Board

2009	Journal of Biological Chemistry.

2008 - present

FEBS Letters.

Outreach

NSF-Sponsored Summer Internship for High School Science Teacher (RET)
Project Dates: 2008 - present
Description: Hosted local high school science teacher in the lab for an NSF-sponsored summer experience.

Peer Reviewed Journal Articles

Ibba, Michael; Bonarius, Dick; Kuhla, Jochen; Smith, Alan; Kuenzi, Martin. 1993. Mode of cultivation is critical for the optimal expression of recombinant hirudin by Saccharomyces cerevisiae. Biotechnology Letters. Vol. 15, no. 7: 667-672.

Ibba, Michael; Kuhla, Jochen; Smith, Alan; Kuenzi, Martin. 1993. Stable continuous constitutive expression of a heterologous protein in Saccharomyces cerevisiae without selection pressure. Applied Microbiology and Biotechnology. Vol. 39, no. 4-5: 526-531.

Ibba, Michael; Kast, Peter; Hennecke, Hauke. 1994. Substrate specificity is determined by amino acid binding pocket size in Escherichia coli phenylalanyl-trna synthetase. Biochemistry. Vol. 33, no. 23: 7107-7112.

Ibba, Michael; Hennecke, Hauke. 1995. Relaxing the substrate specificity of an aminoacyl-trna synthetase allows in vitro and in vivo synthesis of proteins containing unnatural amino acids. FEBS Letters. Vol. 364, no. 3: 272-275.

Ibba, Michael; Johnson, Christopher M.; Hennecke, Hauke; Fersht, Alan R. 1995. Increased rates of trna charging through modification of the enzyme-aminoacyl-adenylate complex of phenylalanyl-trna synthetase. FEBS Letters. Vol. 358, no. 3: 293-296.

Lloyd, Adrian J.; Thomann, Hans-Ulrich; Ibba, Michael; Soll, Dieter. 1995. A broadly applicable continuous spectrophotometric assay for measuring aminoacyl-trna synthetase activity. Nucleic Acids Research. Vol. 23, no. 15: 2886-2892.

Ibba, Michael; Hong, Kwang-Won; Sherman, Joyce M.; Sever, Sanja; Soell, Dieter. 1996. Interactions between trna identity nucleotides and their recognition sites in glutaminyl-trna synthetase determine the cognate amino acid affinity of the enzyme. Proceedings of the National Academy of Sciences of the United States of America. Vol. 93, no. 14: 6953-6958.

Ibba, Michael; Hong, Kwang-Won; Soell, Dieter. 1996. Glutaminyl-trna synthetase: From genetics to molecular recognition. Genes To Cells. Vol. 1, no. 5: 421-427.

Kitabatake, Makoto; Ibba, Michael; Hong, Kwang-Won; Soll, Dieter; Inokuchi, Hachiro. 1996. Genetic analysis of functional connectivity between substrate recognition domains of Escherichia coli glutaminyl-trna synthetase. Molecular and General Genetics. Vol. 252, no. 6: 717-722.

Thomann, Hans-Ulrich; Ibba, Michael; Hong, Kwang-Won; Soll, Dieter. 1996. Homologous expression and purification of mutants of an essential protein by reverse epitope-tagging. Bio-Technology (New York). Vol. 14, no. 1: 50-55.

Freist, Wolfgang; Gauss, Dieter H.; Ibba, Michael; Soll, Dieter. 1997. Glutaminyl-trna synthetase. Biological Chemistry. Vol. 378, no. 10: 1103-1117.

Ibba, Michael; Bono, James L.; Rosa, Patricia A.; Soll, Dieter. 1997. Archaeal-type lysyl-trna synthetase in the Lyme disease spirochete Borrelia burgdorferi. Proceedings of the National Academy of Sciences of the United States of America. Vol. 94, no. 26: 14383-14388.

Ibba, Michael; Curnow, Alan W.; Soll, Dieter. 1997. Aminoacyl-trna synthesis: Divergent routes to a common goal. Trends in Biochemical Sciences. Vol. 22, no. 2: 39-42.

Ibba, Michael; Morgan, Susan; Curnow, Alan W.; Pridmore, David R.; Vothknecht, Ute C.; Gardner, Warren; Lin, Winston; Woese, Carl R.; Soll, Dieter. 1997. A euryarchaeal lysyl-trna synthetase: Resemblance to class I synthetases. Science (Washington D C). Vol. 278, no. 5340: 1119-1122.

Hong, Kwang-Won; Ibba, Michael; Soll, Dieter. 1998. Retracing the evolution of amino acid specificity in glutaminyl-trna synthetase. FEBS Letters. Vol. 434, no. 1-2: 149-154.

Liu, Jinhua; Ibba, Michael; Hong, Kwang-Won; Soll, Dieter. 1998. The terminal adenosine of trnagln mediates trna-dependent amino acid recognition by glutaminyl-trna synthetase. Biochemistry. Vol. 37, no. 27: 9836-9842.

Ibba, Michael; Losey, Heather C.; Kawarabayasi, Yutaka; Kikuchi, Hisasi; Bunjun, Shipra; Soll, Dieter. 1999. Substrate recognition by class I lysyl-trna synthetases: A molecular basis for gene displacement. Proceedings of the National Academy of Sciences of the United States of America. Vol. 96, no. 2: 418-423.

Ibba, Michael; Sever, Sanja; Praetorius-Ibba, Mette; Soll, Dieter. 1999. Transfer Rna identity contributes to transition state stabilization during aminoacyl-trna synthesis. Nucleic Acids Research. Vol. 27, no. 18: 3631-3637.

Ibba, Michael; Soll, Dieter. 1999. Quality control mechanisms during translation. Science (Washington D C). Vol. 286, no. 5446: 1893-1897.

Lenhard, Boris; Orellana, Omar; Ibba, Michael; Weygand-Durasevic, Ivana. 1999. trna recognition and evolution of determinants in seryl-trna synthesis. Nucleic Acids Research. Vol. 27, no. 3: 721-729.

Tumbula, Debra; Vothknecht, Ute C.; Kim, Hyun-soo; Ibba, Michael; Min, Bokkee; Li, Tong; Pelaschier, Joanne; Stathopoulos, Constantinos; Becker, Hubert; Soll, Dieter. 1999. Archaeal aminoacyl-trna synthesis: Diversity replaces dogma. Genetics. Vol. 152, no. 4: 1269-1276.

Behrens, Carsten; Nielsen, Jens N.; Fan, Xue-Jun; Doisy, Xavier; Kim, Ki-Hyun; Praetorius-Ibba, Mette; Nielsen, Peter E.; Ibba, Michael. 2000. Development of strategies for the site-specific in vivo incorporation of photoreactive amino acids: p-azidophenylalanine, p-acetylphenylalanine and benzofuranylalanine. Tetrahedron. Vol. 56, no. 48: 9443-9449.

Ibba, Michael; Becker, Hubert D.; Stathopoulos, Constantinos; Tumbula, Debra L.; Soll, Dieter. 2000. The Adaptor hypothesis revisited. Trends in Biochemical Sciences. Vol. 25, no. 7: 311-316.

Praetorius-Ibba, Mette; Stange-Thomann, Nicole; Kitabatake, Makoto; Ali, Kamilah; Soll, Iris; Carter, Charles W., Jr.; Ibba, Michael; Soll, Dieter. 2000. Ancient adaptation of the active site of tryptophanyl-trna synthetase for tryptophan binding. Biochemistry. Vol. 39, no. 43: 13136-13143.

Soll, Dieter; Becker, Hubert D.; Plateau, Pierre; Blanquet, Sylvain; Ibba, Michael. 2000. Context-dependent anticodon recognition by class I lysyl-trna synthetases. Proceedings of the National Academy of Sciences of the United States of America. Vol. 97, no. 26: 14224-14228.

Stathopoulos, Constantinos; Li, Tong; Longman, Randy; Vothknecht, Ute C.; Becker, Hubert D.; Ibba, Michael; Soll, Dieter. 2000. One polypeptide with two aminoacyl-trna synthetase activities. Science (Washington D C). Vol. 287, no. 5452: 479-482.

Woese, Carl R.; Olsen, Gary J.; Ibba, Michael; Soll, Dieter. 2000. Aminoacyl-trna synthetases, the genetic code, and the evolutionary process. Microbiology and Molecular Biology Reviews. Vol. 64, no. 1: 202-236.

Ibba, Michael. 2001. Protein synthesis: Discriminating right from wrong. Science (Washington D C). Vol. 294, no. 5540: 70-71.

Ibba, Michael; Soll, Dieter. 2001. The renaissance of aminoacyl-trna synthesis. EMBO Reports. Vol. 2, no. 5: 382-387.

Ibba, Michael; Stathopoulos, Constantinos; Soll, Dieter. 2001. Protein synthesis: Twenty three amino acids and counting. Current Biology. Vol. 11, no. 14: R563-R565.

McCloskey, James A.; Graham, David E.; Zhou, Shaolian; Crain, Pamela F.; Ibba, Michael; Konisky, Jordan; Soll, Dieter; Olsen, Gary J. 2001. Post-transcriptional modification in archaeal trnas: Identities and phylogenetic relations of nucleotides from mesophilic and hyperthermophilic Methanococcales. Nucleic Acids Research. Vol. 29, no. 22: 4699-4706.

Raczniak, Gregory; Ibba, Michael; Soll, Dieter. 2001. Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. Toxicology. Vol. 160, no. 1-3: 181-189.

Raczniak, Gregory; Stathopoulos, Constantinos; Ibba, Michael; Soll, Dieter. 2001. Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. International Journal of Molecular Medicine. Vol. 8, no. Supplement 1: S47.

Ruan, Benfang; Ahel, Ivan; Ambrogelly, Alex; Becker, Hubert D.; Bunjun, Shipra; Feng, Liang; Tumbula-Hansen, Debra; Ibba, Michael; Korencic, Dragana; Kobayashi, Hiroyuki; Jacquin-Becker, Clarisse; Mejlhede, Nina; Min, Bokkee; Raczniak, Gregory; Rinehart, Jesse; Stathopoulos, Constantinos; Li, Tong; Soll, Dieter. 2001. Genomics and the evolution of aminoacyl-trna synthesis. Acta Biochimica Polonica. Vol. 48, no. 2: 313-321.

Ambrogelly, Alexandre; Korencic, Dragana; Ibba, Michael. 2002. Functional annotation of class I lysyl-trna synthetase phylogeny indicates a limited role for gene transfer. Journal of Bacteriology. Vol. 184, no. 16: 4594-4600.

Ibba, Michael; Soll, Dieter. 2002. Genetic code: Introducing pyrrolysine. Current Biology. Vol. 12, no. 13: R464-R466.

Pavlickova, Petra; Jensen, Nina Mejlhede; Paul, Hubert; Schaeferling, Michael; Giammasi, Chiara; Kruschina, Margit; Du, Wei-Dong; Theisen, Michael; Ibba, Michael; Ortigao, Flavio; Kambhampati, Dev. 2002. Antibody detection in human serum using a versatile protein chip platform constructed by applying nanoscale self-assembled architectures on gold. Journal of Proteome Research. Vol. 1, no. 3: 227-231.

Terada, Takaho; Nureki, Osamu; Ishitani, Ryuichiro; Ambrogelly, Alexandre; Ibba, Michael; Soll, Dieter; Yokoyama, Shigeyuki. 2002. Functional convergence of two lysyl-trna synthetases with unrelated topologies. Nature Structural Biology. Vol. 9, no. 4: 257-262.

Ahel, Ivan; Korencic, Dragana; Ibba, Michael; Soll, Dieter. 2003. Trans-editing of mischarged trnas. Proceedings of the National Academy of Sciences of the United States of America. Vol. 100, no. 26: 15422-15427.

Jester, Brian C.; Levengood, Jeffrey D.; Roy, Herve; Ibba, Michael; Devine, Kevin M. 2003. Nonorthologous replacement of lysyl-trna synthetase prevents addition of lysine analogues to the genetic code. Proceedings of the National Academy of Sciences of the United States of America. Vol. 100, no. 24: 14351-14356.

Mejlhede, Nina; Monthan, Amanda; Theisen, Michael; Ibba, Michael. 2003. Differentiation of Borrelia burgdorferi sensu lato strains using class I lysyl-trna synthetase-encoding genes. Medical Microbiology and Immunology. Vol. 192, no. 2: 79-83.

Polycarpo, Carla; Ambrogelly, Alexandre; Ruan, Benfang; Tumbula-Hansen, Debra; Ataide, Sandro F.; Ishitani, Ryuichiro; Yokoyama, Shigeyuki; Nureki, Osamu; Ibba, Michael; Soll, Dieter. 2003. Activation of the pyrrolysine suppressor trna requires formation of a ternary complex with class I and class Ii lysyl-trna synthetases. Molecular Cell. Vol. 12, no. 2: 287-294.

Praetorius-Ibba, Mette; Ibba, Michael. 2003. Aminoacyl-trna synthesis in archaea: Different but not unique. Molecular Microbiology. Vol. 48, no. 3: 631-637.

Ataide, Sandro F.; Ibba, Michael. 2004. Discrimination of cognate and noncognate substrates at the active site of class Ii lysyl-trna synthetase. Biochemistry. Vol. 43, no. 37: 11836-11841.

Bentin, Thomas; Hamzavi, Ramin; Salomonsson, Johan; Roy, Herve; Ibba, Michael; Nielsen, Peter E. 2004. Photoreactive bicyclic amino acids as substrates for mutant Escherichia coli phenylalanyl-trna synthetases. Journal of Biological Chemistry. Vol. 279, no. 19: 19839-19845.

Ibba, Michael; Francklyn, Christopher. 2004. Turning trna upside down: When aminoacylation is not a prerequisite to protein synthesis. Proceedings of the National Academy of Sciences of the United States of America. Vol. 101, no. 20: 7493-7494.

Ibba, Michael; Soll, Dieter. 2004. Aminoacyl-trnas: setting the limits of the genetic code. Genes & Development. Vol. 18, no. 7: 731-738.

Korencic, Dragana; Ahel, Ivan; Schelert, James; Sacher, Meik; Ruan, Berfang; Stathopoulos, Constantinos; Blum, Paul; Ibba, Michael; Soll, Dieter. 2004. A freestanding proofreading domain is required for protein synthesis quality control in Archaea. Proceedings of the National Academy of Sciences of the United States of America. Vol. 101, no. 28: 10260-10265.

Levengood, Jeffrey; Ataide, Sandro F.; Roy, Herve; Ibba, Michael. 2004. Divergence in noncognate amino acid recognition between class I and class Ii lysyl-trna synthetases. Journal of Biological Chemistry. Vol. 279, no. 17: 17707-17714.

Roy, Herve; Ling, Jiqiang; Irnov, Michael; Ibba, Michael. 2004. Post-transfer editing in vitro and in vivo by the beta subunit of phenylalanyl-trna synthetase. EMBO (European Molecular Biology Organization) Journal. Vol. 23, no. 23: 4639-4648.

Arribrogelly, Alexandre; Frugier, Magall; Ibba, Michael; Soll, Dieter; Giege, Richard. 2005. Transfer Rna recognition by class I lysyl-trna synthetase from the Lyme disease pathogen Borrelia burgdorferi. FEBS Letters. Vol. 579, no. 12: 2629-2634.

Ataide, Sandro F.; Jester, Brian C.; Devine, Kevin M.; Ibba, Michael. 2005. Stationary-phase expression and aminoacylation of a transfer-rna-like small Rna. EMBO Reports. Vol. 6, no. 8: 742-747.

Praetorius-Ibba, Mette; Rogers, Theresa E.; Samson, Rachel; Kelman, Zvi; Ibba, Michael. 2005. Association between archaeal prolyl- and leucyl-trna synthetases enhances trna(pro) aminoacylation. Journal of Biological Chemistry. Vol. 280, no. 28: 26099-26104.

Roy, Herve; Ling, Jiqiang; Alfonzo, Juan; Ibba, Michael. 2005. Loss of editing activity during the evolution of mitochondrial phenylalanyl-trna synthetase. Journal of Biological Chemistry. Vol. 280, no. 46: 38186-38192.

Sauerwald, Anselm; Zhu, Wenhong; Major, Tiffany A.; Roy, Herve; Patioura, Sotiria; Jahn, Dieter; Whitman, William B.; Yates, John R., III; Ibba, Michael; Soell, Dieter. 2005. Rna-dependent cysteine biosynthesis in archaea. Science (Washington D C). Vol. 307, no. 5717: 1969-1972.

Ataide, Sandro F.; Ibba, Michael. 2006. Small molecules: Big players in the evolution of protein synthesis. ACS Chemical Biology. Vol. 1, no. 5: 285-297.

Metlitskaya, Anastasia; Kazakov, Teymur; Kommer, Aigar; Pavlova, Olga; Praetorius-Ibba, Mette; Ibba, Michael; Krasheninnikov, Igor; Kolb, Vyacheslav; Khmel, Inessa; Severinov, Konstantin. 2006. Aspartyl-trna synthetase is the target of peptide nucleotide antibiotic Microcin C. Journal of Biological Chemistry. Vol. 281, no. 26: 18033-18042.

Roy, Herve; Ibba, Michael. 2006. Phenylalanyl-trna synthetase contains a dispensable Rna-binding domain that contributes to the editing of noncognate aminoacyl-trna. Biochemistry. Vol. 45, no. 30: 9156-9162.

Rubio, Mary Anne T.; Ragone, Frank L.; Gaston, Kirk W.; Ibba, Michael; Alfonzo, Juan D. 2006. C to U editing stimulates A to I editing in the anticodon loop of a cytoplasmic threonyl trna in Trypanosoma brucei. Journal of Biological Chemistry. Vol. 281, no. 1: 115-120.

Wang, Shiming; Praetorius-Ibba, Mette; Ataide, Sandro F.; Roy, Herve; Ibba, Michael. 2006. Discrimination of cognate and noncognate substrates at the active site of class I Lysyl-trna synthetase. Biochemistry. Vol. 45, no. 11: 3646-3652.

Yuan, Jing; Sauerwald, Anselm; Zhu, Wenhong; Major, Tiffany; Roy, Herve; Palioura, Sotiria; Jahn, Dieter, III; Whitman, William; Yates, John; Ibba, Michael; Soll, Dieter. 2006. Rna-dependent cysteine biosynthesis in archaea. FASEB Journal. Vol. 20, no. 4, Part 1: A503-A504.

Hausmann, C.D. and Ibba, M. 2008. Aminoacyl-tRNA synthetase complexes: molecular multitasking revealed. FEMS Microbiology Reviews. Vol. 32: 705-721.

Hausmann, C.D. and Ibba, M. 2008. Structural and functional mapping of the archaeal multi-aminoacyl-tRNA synthetase complex. FEBS Letters. Vol. 582: 2178-2182.

Ibba, M. 2008. Methods for studying aminoacyl-tRNA. Methods. Vol. 44: 73.

Roy, H. and Ibba, M. 2008. Monitoring Lys-tRNALys phosphatidylglycerol transferase activity. Methods. Vol. 44: 164-169.

Roy, H. and Ibba, M. 2008. RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors. Proceedings of the National Academy of Sciences USA. Vol. 105: 4667-4672. (IF: 9.598)

Yadavalli, S.S., Musier-Forsyth, K. and Ibba, M. 2008. The return of pre-transfer editing in protein synthesis. Proceedings of the National Academy of Sciences USA. Vol. 105: 19031-19032.