OSU:pro

Current OSU Appointments

Professor, Veterinary Biosciences

Professor, Molecular Virology, Immunology & Medical Genetics

Chapters In Books

Risser R, McCubrey J, Green PL, Horowitz JM, Sinaiko C. 1984. DNA transfection studies of endogenous ecotropic MuLV. In Gene Transfer and Cancer. Edited by Pearson ML. New York: Raven Press. 157-163.

Green PL, Chen ISY. 1994. Molecular features of the human T-cell leukemia virus: Mechanisms of transformation and leukemogenicity. In The Retroviridae. Vol. 3. Edited by Levy JA. New York: Plenum Publishing. 277-312.

Green, PL, Ross TM, Anderson, M, Minella AC. 1999. The Role of the tax Gene in Human T-cell Leukemia Virus Type 2-mediated Transformation of Human T-lymphocytes. In Molecular Pathogenesis of HTLV: A Current Perspective. Edited by Semmes OJ and Hammarskjold ML. USA: Vandemere Press. 71-77.

Green PL, Chen ISY. 2001. Human T-cell leukemia virus types 1 and 2. In Fields Virology Fourth Edition. Edited by Knipe, D, Howley, P, Griffin, D, Lamb, R, Martin, M, and Straus, S. Philidelphia, PA: Lippincott Williams & Wilkins.

Anderson M, Green, PL. 2005. Growth and manipulation of a human T-cell leukemia virus type 2 full-length molecular clone. In Human Retrovirus Protocols: Virology and Molecular Biology. Edited by Zhu, T. Totawa, NJ: The Human Press Inc. 409-423.

Arnold J, Green PL. 2008. HTLV-1 and HTLV-2: mechanisms of pathogenesis. In Human Cancer Viruses Principles of Transformation and Pathogenesis. Vol. 1. Edited by Nicholas J, Jeang KT, and Wu TC. Basel: Transl Res Biomed. Basel, Karger. 211-227.

Degrees

1980	B.S., University of Wisconsin, Zoology

1988	Ph.D., University of Wisconsin, Oncology

1990	Postdoctoral, University of California, Los Angeles, Hematology and Oncology

Honors

1988	Dorothy and Charles Inbusch Award for Medical Research Excellence.

1989 - 1991

American Cancer Society National Fellow.

1994 - 1999

Leukemia Society of America Scholar.

2000	Pfizer Animal Health Award for Research Excellence.

2004	United Who's Who Honored Lifetime Member.

2006	AAAS Fellow.

2007	Award for Exceptional Contribution to the Field of HTLV and Related Viruses.

2008	Charles C. Capen Teaching Excellence Award.

2009	The Ohio State University Distinguished Scholar Award.

2009	Fellow, American Academy of Microbiology.

Peer Reviewed Journal Articles

Kim S-J, Ding W, Albrecht B, Green PL, Lairmore MD. 2003. A conserved calcineurin-binding motif in human T lymphotropic virus type 1 p12I functions to modulate nuclear factor of activated T cell activation.  Journal of Biological Chemistry. Vol. 278, no. 18: 15550-7.

Narayan M, Younis I, D'Agostino D, Green PL. 2003. Functional domain structure of human T-cell leukemia virus type 2 rex.  Journal of Virology. Vol. 77, no. 23: 12829-40.

Ye J, Silverman L, Lairmore MD, Green PL. 2003. HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro.  Blood. Vol. 102, no. 12: 3963-9.

Ye J, Xie L, Green PL. 2003. Tax and overlapping rex sequences do not confer the distinct transformation tropisms of human T-cell leukemia virus types 1 and 2.  Journal of Virology. Vol. 77, no. 14: 7728-35.

Green, Patrick L. 2004. HTLV-1 p30II: selective repressor of gene expression. Retrovirology. Vol. 1: 40.

Younis I, Khair L, Dundr M, Lairmore MD, Franchini G, Green PL. 2004. Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator.  Journal of Virology. Vol. 78, no. 20: 11077-83.

Anderson MD, Ye J, Xie L, Green PL. 2005. Transformation studies with a human T-cell leukemia virus type 1 molecular clone.  Journal of Virological Methods. Vol. 116, no. 2: 195-202.

Feuer G, Green PL. 2005. Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2.  Oncogene. Vol. 24, no. 39: 5996-6004.

Niinuma A, Higuchi M, Takahashi M, Oie M, Tanaka Y, Gejyo F, Tanaka N, Sugamura K, Xie L, Green PL, Fujii M. 2005. Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus.  Journal of Virology. Vol. 79, no. 18: 11925-34.

Xie, Li; Green, Patrick L. 2005. Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2. Journal of virology. Vol. 79, no. 23: 14536-45.

Younis I, Green PL. 2005. The human T-cell leukemia virus Rex protein.  Frontiers in Bioscience. Vol. 10: 431-45.

Younis I, Yamamoto B, Phipps A, Green PL. 2005. Human T-cell leukemia virus type 1 expressing nonoverlapping tax and rex genes replicates and immortalizes primary human T lymphocytes but fails to replicate and persist in vivo.  Journal of Virology. Vol. 79, no. 23: 14473-81.

Arnold J, Yamamoto B, Li M, Phipps A, Younis I, Lairmore MD, Green PL. 2006. Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1.  Blood. Vol. 107, no. 10: 3976-82.

Hiraragi H, Kim S-J, Phipps AJ, Silic-Benussi M, Ciminale V, Ratner L, Green PL, Lairmore MD. 2006. Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13(II) is required for viral infectivity in vivo.  Journal of Virology. Vol. 80, no. 7: 3469-76.

Ishioka K; Higuchi M, Takahashi M, Yoshida S, Oie M, Tanaka Y, Takahashi S, Xie L, Green PL, Fujii M. 2006. Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.  Retrovirology. Vol. 3: 71.

Xie L, Yamamoto B, Haoudi A, Semmes OJ, Green PL. 2006. PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo.  Blood. Vol. 107, no. 5: 1980-8.

Younis I, Boris-Lawrie K, Green PL. 2006. Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription.  Journal of Virology. Vol. 80, no. 1: 181-91.

Bolinger C, Hartman T, Yilmaz A, Kovacic M, Fernandez S, Ye J, Forget M, Green PL, Boris-Lawrie K. 2007. RNA helicase A is necessary for HTLV-1 replication and interacts with the 5'UTR of divergent lymphotropic retroviruses to facilitate Gag production.  Nuc Acid Res. Vol. 35: 2629-2642.

Bolinger C, Yilmaz A, Roberts Hartman T, Butsch Kovacic M, Fernandez S, Ye J, Forget M, Green PL, Boris-Lawrie K. 2007. RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1.  Nucleic Acids Research. Vol. 35, no. 8: 2629-42.

Li M, Green PL. 2007. Detection and quantitation of HTLV-1 and HTLV-2 mRNA species by real-time RT-PCR.  J Virol Meth. Vol. 142, no. 1-2: 159-68.

Matsuoka M, Watanabe T, Kannagi M, Bangham C, Grassmann R, Marriott SJ, Green PL, Jeang KT. 2007. Meeting report on the 13th International Conference on Human Retrovirology:Human T-cell leukemia virus research 30 years after adult T-cell leukemia.  Cancer Research. Vol. 67: 10638-10641.

Twizere J-C, Springael J-Y, Boxus M, Burny A, Dequiedt F, Dewulf J-F, Duchateau J, Portetelle D, Urbain P, Van Lint C, Green PL, Mahieux R, Parmentier M, Willems L, Kettmann L. 2007. Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.  Blood. Vol. 109, no. 3: 1051-60.

Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL. 2008. Human T-cell leukemia virus type 1 antisense encoded gene, Hbz, promotes T-lymphocyte proliferation.  Blood. Vol. 112: 3788-3797.

Hernandez JM, Floyd DH, Weilbaecher KN, Green PL, Boris-Lawrie K. 2008. Multiple facets of junD gene expression are atypical among AP-1 family members.  Oncogene. Vol. 27: 4757-4767.

Nadella MPV, Shu S, Dirksen WP, Thudi NK, Nadella KS, Fernandez SA, Lairmore MD, Green PL Rosol TJ. 2008. Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation.  Retrovirology. Vol. 5: 46.

Yamamoto B, Li M, Kesic M, Younis I, Lairmore MD, Green PL. 2008. Human T-cell leukemia virus type 2 post transcriptional control protein, p28 is required for viral Infectivity in vivo.  Retrovirology. Vol. 5: 38.

Li M, Kesic M, Yin H, Lianbo Y, Green PL. 2009. Kinetic analysis of Human T-cell leukemia virus type 1 gene expression in cell culture and infected animals.  J Virology. Vol. 83: 3788-3797.

Xie L, Kesic M, Yamamoto B, Li M, Younis I, Lairmore MD, Green PL. 2009. HTLV-2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication.  J Virology. Vol. 83: 5232-5243.