Current OSU Appointment

Assistant Professor, Physiology and Cell Biology

Abstracts

Davis JP, Snyder CH, Johnson JD. 1996. "Generation of "Artificial" calcium (Ca) transients for the study of Ca exchange with Ca-binding proteins." Abstract. Biophys J, 70: A259. []

Luo Y, Davis JP, Tikunova SB, Smillie LB, Rall JA. 2001. "TnC mutants influence relaxation in skeletal muscle in the presence of low phosphate." Abstract. Biophys J, 80: A274-A275. []

Tikunova SB, Davis JP, Rall JA. 2004. "Engineering cardiac troponin C (cTnC) mutants with dramatically altered Ca2+ dissociation rates as molecular tools to study cardiac muscle relaxation." Abstract. Biophys J, 86: A394. []

Davis JP, Gomes AV, Tikunova SB, Rall JA, Potter JD. 2005. "Effects of familial hypertrophic cardiomyopathy (FHC) mutations in troponin I on Ca2+ dissociation from the troponin complex and Ca2+ sensitivity of force development." Abstract. Biophys J, 88: A479. []

Gillis TE, Clemmens EW, Rivera AJ, Tikunova SB, Davis JP, Regnier M. 2005. "Cardiac versus skeletal muscle: differences in thin filament regulation of force development." Abstract. Biophys J, 88: A314. []

Swartz DR, Yang Z, Richard J, Eugene S, Tikunova S, Davis JP. 2005. "TnC-TnI affinity determines thin filament activation in myofibrils." Abstract. Biophys J, 88: A131. []

Davis JP. 2006. "Molecular determinants of cardiac and skeletal muscle relaxation: Role of Ca2+ Dissociation from Troponin C." Abstract. The Physiologist. []

Davis JP, Tikunova SB, Kobayashi T, Alionte C, Warren CM, Rall JA, Solaro RJ. 2006. "Thin and Thick Filament Proteins Affect Ca2+ Binding and Exchange with Cardiac Troponin C." Abstract. Biophys J: A117. []

Engel PL, Kobayashi T, Biesiadecki BJ, Wu S, Davis JP, Tikunova SB, Solaro RJ. 2006. "An N-terminal region surrounding Ala 66 in cardiac troponin I is critical in signaling cross-bridge dependent activation." Abstract. Biophys J: A337. []

Tikunova SB, Alionte C, Gomes AV, Potter JD, Rall JA, Davis JP. 2006. "Effect of Cardiac Troponin C Mutations on Calcium Binding and Exchange with the Troponin Complex and Muscle Force Generation." Abstract. Biophys J: A117-118. []

Books and Monographs

Dr Jonathan Paul Davis. 1999. Characterizing the response of calcium signal transducers to generated calcium transients and modifying Ca2+ and Mg2+ affinity using site-directed mutagenesis of EF-hands. Dissertation ed. The Ohio State University.

Chapters In Books

Davis JP, Wahr PA, Rall JA. 2003. Molecular aspects of muscular contraction. In Principles of Exercise Biochemistry, 3rd edition. Edited by J.R. Poortmans. S. Karger. 46:62-86.

Degrees

1993	B.A., Greenville College, Mathematics and Physics

1998	Ph.D., The Ohio State University, Biophysics

Honors

2006	Excellence in Teaching Award.

Memberships

Member. Biophysical Society. Motility Subgroup

Member. American Society for Biochemistry and Molecular Biology

Peer Reviewed Journal Articles

Cho, Moo Je; Vaghy, Pal L.; Kondo, Ritsu; Lee, Sang Hyoung; Davis, Jonathan P. 1998. Reciprocal regulation of mammalian nitric oxide synthase and calcineurin by plant calmodulin isoforms. Biochemistry. Vol. 37, no. 45: 15593-15598.

Wang, Songtao; George, Samuel E.; Davis, Jonathan P. 1998. Structural determinants of Ca2+ exchange and affinity in the C terminal of cardiac troponin C. Biochemistry. Vol. 37, no. 41: 14539-14544.

Davis, Jonathan P. 1999. Characterizing the response of calcium signal transducers to generated calcium transients. Biochemistry. Vol. 38, no. 13: 4235-4244.

Black, D. J.; Tikunova, Svetlana B.; Johnson, J. David; Davis, Jonathan P. 2000. Acid pairs increase the N-terminal Ca2+ affinity of Cam by increasing the rate of Ca2+ association. Biochemistry. Vol. 39, no. 45: 13831-13837.

Tikunova, Svetlana B.; Black, D. J.; Johnson, J. David; Davis, Jonathan P. 2001. Modifying magnesium binding and exchange with the N-terminal of calmodulin. Biophysical Journal. Vol. 80, no. 1 Part 2: 404a.

Tikunova, Svetlana B.; Black, D. J.; Johnson, J. David; Davis, Jonathan P. 2001. Modifying Mg2+ binding and exchange with the N-terminal of calmodulin. Biochemistry. Vol. 40, no. 11: 3348-3353.

Davis, Jonathan P. 2002. Engineering competitive magnesium binding into the first Ef-hand of skeletal troponin C. Journal of Biological Chemistry. Vol. 277, no. 51: 49716-49726.

Davis, Jonathan P. 2002. Engineering Mg2+ binding into the regulatory domain of skeletal troponin C. Biophysical Journal. Vol. 82, no. 1 Part 2: 364a.

Davis, Jonathan P. 2002. Troponin C interaction with the inhibitory region of troponin I (tni96-148) as a model for Ca2+ dissociation from troponin in skeletal muscle. Biophysical Journal. Vol. 82, no. 1 Part 2: 364a.

Luo, Ye; Davis, Jonathan P. 2002. Determinants of relaxation rate in rabbit skinned skeletal muscle fibres. Journal of Physiology (Cambridge). Vol. 545, no. 3: 887-901.

Tikunova, Svetlana B.; Rall, Jack A.; Davis, Jonathan P. 2002. Effect of hydrophobic residue substitutions with glutamine on Ca2+ binding and exchange with the N-domain of troponin C. Biochemistry. Vol. 41, no. 21: 6697-6705.

Tikunova, Svetlana B.; Rall, Jack A.; Davis, Jonathan P. 2002. Role of hydrophobic residues in Ca2+ binding and exchange with the regulatory domain of skeletal troponin C. Biophysical Journal. Vol. 82, no. 1 Part 2: 386a.

van Lierop, Jacquelyn E.; Wilson, David P.; Davis, Jonathan P. 2002. Activation of smooth muscle myosin light chain kinase by calmodulin. Role of Lys30 and Gly40. Journal of Biological Chemistry. Vol. 277, no. 8: 6550-6558.

Davis, Jonathan P. 2003. Conserved hydrophobic beta-sheet and beta-sheet interacting residues are critical for troponin C (tnc) function in skeletal muscle. Biophysical Journal. Vol. 84, no. 2 Part 2: 566a.

Luo, Ye; Davis, Jonathan, P; Tikunova, Svetlana, B; Smillie, Lawrence, B; Rall, Jack A. 2003. Myofibrillar determinants of rate of relaxation in skinned skeletal muscle fibers. Advances in experimental medicine and biology. Vol. 538: 573-81; discussion 581.

Davis, Jonathan P. 2004. Measurement of Ca2+ dissociation rates from troponin C (tnc) in skeletal myofibrils. Biophysical Journal. Vol. 86, no. 1: 218a.

Davis, Jonathan P. 2004. Mutations of hydrophobic residues in the n-terminal domain of troponin C affect calcium binding and exchange with the troponin C-troponin I96-148 complex and muscle force production. Journal of Biological Chemistry. Vol. 279, no. 17: 17348-17360.

Gomes, Aldrin, V; Venkatraman, Gayathri; Davis, Jonathan, P; Tikunova, Svetlana, B; Engel, Patti; Solaro, R John; Potter, James D. 2004. Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. The Journal of biological chemistry. Vol. 279, no. 48: 49579-87.

Swartz, Darl R.; Yang, Zhenyun; Tikunova, Svetlana B.; Davis, Jonathan P. 2004. The role of Tnc - Tni regulatory interactions in the B to C-state transition and solid-phase signal transduction in myofibrillar thin filaments. Biophysical Journal. Vol. 86, no. 1: 219a.

Tikunova, Svetlana B.; Davis, Jonathan P. 2004. Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C. Journal of Biological Chemistry. Vol. 279, no. 34: 35341-35352.

Swartz DR, Yang Z, Sen A, Tikunova SB, Davis JP. 2006. Solid-phase signal transduction along myofibrillar thin filaments. J Mol Biol.

Davis JP, Alionte C, Kobayashi T, Solaro RJ, Swartz DR, Tikunova SB. 2007. Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J. Vol. 92: 3195-3206. (IF: 4.757)

Davis JP, Tikunova SB. 2007. Ca2+ exchange with troponin C and cardiac muscle dynamics. Cardiovasc Res. (IF: 5.826)

Engel PL, Kobayashi T, Biesiadecki B, Davis JP, Tikunova SB, Wu S, Solaro RJ. 2007. Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. J Biol Chem. Vol. 282: 183-193. (IF: 5.808)

Kreutziger KL, Gillis TE, Davis JP, Tikunova SB, Regnier M. 2007. Influence of enhanced troponin C Ca2+ binding affinity on cooperative thin filament activation in rabbit skeletal muscle. J Physiol. Vol. 583: 337-350.

Monasky MM, Varian KD, Davis JP, Janssen PM. 2007. Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium. Pflugers Arch. (IF: 4.807)

Norman C, Rall JA, Tikunova SB, Davis JP. 2007. Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities. Am J Physiol Heart Circ Physiol. Vol. 293: H2580-H2587. (IF: 3.724)

Positions

1993 - 1994

Teaching Assistant, The Ohio State University, College of Biological Sciences. Columbus, OH, United States.

1999	Postdoctoral Researcher, Emory University, Department of Cell Biology, Laboratory of Dr. H. Criss Hartzell. Atlanta, GA, United States.

2000 - 2003

Postdoctoral Researcher, The Ohio State University, Department of Physiology and Cell Biology, Laboratory of Dr. J. Rall. Columbus, OH, United States.

2001 - 2005

Lecturer, Biophysics 702, Advanced Experimental Methods in Biophysics, The Ohio State University, College of Biological Sciences. Columbus, OH, United States.

2003 - present

Lecturer, Biomedical Engineering 701, Survey of Cardiovascular Bioengineering, The Ohio State University, College of Medicine. Columbus, OH, United States.

2003 - 2005

Research Scientist, The Ohio State University, Department of Physiology and Cell Biology. Columbus, OH, United States.

2004 - present

Mentor, Biophysics Student Group, The Ohio State University, College of Biological Sciences. Columbus, OH, United States.

2005 - present

Lecturer, Physiology 602, Organ System Physiology, Muscle, The Ohio State University, College of Medicine. Columbus, OH, United States.

2005 - 2006

Research Assistant Professor, The Ohio State University, Medicine, Department of Physiology and Cell Biology. Columbus, OH, United States.

2006 - present

Assistant Professor, The Ohio State University, Medicine, Department of Physiology and Cell Biology. Columbus, OH, United States.

2006 - present

Lecturer, Physiology 911.27, Advanced Cardiac Physiology, The Ohio State University, College of Medicine. Columbus, OH, United States.

Presentations

Other Presentations

Local

Dr Jonathan Paul Davis. 2003. . Presented at Eastern Virginia School of Medicine, Department of Physiological Sciences. (October 30)

Dr Jonathan Paul Davis. 2003. . Presented at Indiana University School of Medicine, Department of Anatomy and Cell Biology. Indianapolis, IN. (December 9)

Dr Jonathan Paul Davis. 2004. . Presented at University of Cincinnati, Department of Molecular Genetics, Biochemistry and MIcrobiology. Cincinnati, OH. (January 28)

Dr Jonathan Paul Davis. 2004. . Presented at Marquette University, Department of Biological Sciences. (May 6)

Dr Jonathan Paul Davis. 2005. . Presented at University of Illinois at Chicago, Department of Physiology and Biophysics. Chicago, IL. (April 19)

Dr Jonathan Paul Davis. 2006. . Presented at The Ohio State University, Department of Sport and Exercise Science. Columbus, OH. (January 20)

Dr Jonathan Paul Davis. 2006. . Presented at Purdue University, Department of Animal Sciences. Lafayette, IN. (March 6)

Dr Jonathan Paul Davis. 2006. . Presented at University of Michigan, Molecular and Integrative Physiology. Ann Arbor, MI. (June 14)

Dr Jonathan Paul Davis. 2006. Design - Molecular basis and evolution of muscles for different activities. Presented at American Physiological Society: Comparative Physiology. (October 8)

© 2004-2009 The Ohio State University