Current OSU Appointment

Professor, College of Pharmacy

Degrees

1986	B.S., University Of Cincinnati, Pharmacy

1990	Ph.D., The Ohio State University, Pharmaceutical chemistry

1992	Postdoctoral, The Ohio State University, Cancer pharmacology

Honors

2006

Fellow.

Peer Reviewed Journal Articles

Dalton, James, T; Yates, Charles, R; Yin, Donghua; Straughn, Arthur; Marcus, Stuart, L; Golub, Allyn, L; Meyer, Marvin C. 2002. Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer. The Journal of pharmacology and experimental therapeutics. Vol. 301, no. 2: 507-12.

He, Yali; Yin, Donghua; Perera, Minoli; Kirkovsky, Leonid; Stourman, Nina; Li, Wei; Dalton, James, T; Miller, Duane D. 2002. Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgen receptor. European journal of medicinal chemistry. Vol. 37, no. 8: 619-34.

Rogers, Tiffani, D; Gades, Naomi, M; Kearby, Jeffrey, D; Virgous, Carlos, K; Dalton, James T. 2002. Chronic restraint via tail immobilization of mice: effects on corticosterone levels and other physiologic indices of stress. Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science. Vol. 41, no. 1: 46-50.

Yates, Charles, R; Chang, Cheng; Kearbey, Jeffrey, D; Yasuda, Kazuto; Schuetz, Erin, G; Miller, Duane, D; Dalton, James, T; Swaan, Peter W. 2003. Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharmaceutical research. Vol. 20, no. 11: 1794-803.

Yin, Donghua; Gao, Wenqing; Kearbey, Jeffrey, D; Xu, Huiping; Chung, Kiwon; He, Yali; Marhefka, Craig, A; Veverka, Karen, A; Miller, Duane, D; Dalton, James T. 2003. Pharmacodynamics of selective androgen receptor modulators. The Journal of pharmacology and experimental therapeutics. Vol. 304, no. 3: 1334-40.

Yin, Donghua; He, Yali; Perera, Minoli, A; Hong, Seoung Soo; Marhefka, Craig; Stourman, Nina; Kirkovsky, Leonid; Miller, Duane, D; Dalton, James T. 2003. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor. Molecular pharmacology. Vol. 63, no. 1: 211-23.

Yin, Donghua; Xu, Huiping; He, Yali; Kirkovsky, Leonid, I; Miller, Duane, D; Dalton, James T. 2003. Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgen receptor. The Journal of pharmacology and experimental therapeutics. Vol. 304, no. 3: 1323-33.

Bohl, Casey, E; Chang, Cheng; Mohler, Michael, L; Chen, Jiyun; Miller, Duane, D; Swaan, Peter, W; Dalton, James T. 2004. A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor. Journal of medicinal chemistry. Vol. 47, no. 15: 3765-76.

Gao, Wenqing; Kearbey, Jeffrey, D; Nair, Vipin, A; Chung, Kiwon; Parlow, A, F; Miller, Duane, D; Dalton, James T. 2004. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology. Vol. 145, no. 12: 5420-8.

Gududuru, Veeresa; Hurh, Eunju; Dalton, James, T; Miller, Duane D. 2004. Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer. Bioorganic & medicinal chemistry letters. Vol. 14, no. 21: 5289-93.

Gududuru, Veeresa; Hurh, Eunju; Durgam, Gangadhar, G; Hong, Seoung Soo; Sardar, Vineet, M; Xu, Huiping; Dalton, James, T; Miller, Duane D. 2004. Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer. Bioorganic & medicinal chemistry letters. Vol. 14, no. 19: 4919-23.

Liu, Ying; Kim, Byung Oh; Kao, Chinghai; Jung, Chaeyong; Dalton, James, T; He, Johnny J. 2004. Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation. The Journal of biological chemistry. Vol. 279, no. 21: 21766-73.

Marhefka, Craig, A; Gao, Wenqing; Chung, Kiwon; Kim, Juhyun; He, Yali; Yin, Donghua; Bohl, Casey; Dalton, James, T; Miller, Duane D. 2004. Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators. Journal of medicinal chemistry. Vol. 47, no. 4: 993-8.

Phelps, Mitch, A; Foraker, Amy, B; Gao, Wenqing; Dalton, James, T; Swaan, Peter W. 2004. A novel rhodamine-riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization studies. Molecular pharmaceutics. Vol. 1, no. 4: 257-66.

Wu, Zengru; Gao, Wenqing; Phelps, Mitch, A; Wu, Di; Miller, Duane, D; Dalton, James T. 2004. Favorable effects of weak acids on negative-ion electrospray ionization mass spectrometry. Analytical chemistry. Vol. 76, no. 3: 839-47.

Bohl, Casey, E; Gao, Wenqing; Miller, Duane, D; Bell, Charles, E; Dalton, James T. 2005. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. Vol. 102, no. 17: 6201-6.

Bohl, Casey, E; Miller, Duane, D; Chen, Jiyun; Bell, Charles, E; Dalton, James T. 2005. Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. The Journal of biological chemistry. Vol. 280, no. 45: 37747-54.

Chen, Jiyun; Hwang, Dong Jin; Bohl, Casey, E; Miller, Duane, D; Dalton, James T. 2005. A selective androgen receptor modulator for hormonal male contraception. The Journal of pharmacology and experimental therapeutics. Vol. 312, no. 2: 546-53.

Chen, Jiyun; Hwang, Dong Jin; Chung, Kiwon; Bohl, Casey, E; Fisher, Scott, J; Miller, Duane, D; Dalton, James T. 2005. In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ring. Endocrinology. Vol. 146, no. 12: 5444-54.

Chen, Jiyun; Kim, Juhyun; Dalton, James T. 2005. Discovery and therapeutic promise of selective androgen receptor modulators. Molecular interventions. Vol. 5, no. 3: 173-88.

Gao, Wenqing; Bohl, Casey, E; Dalton, James T. 2005. Chemistry and structural biology of androgen receptor. Chemical reviews. Vol. 105, no. 9: 3352-70.

Gao, Wenqing; Reiser, Peter, J; Coss, Christopher, C; Phelps, Mitch, A; Kearbey, Jeffrey, D; Miller, Duane, D; Dalton, James T. 2005. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. Vol. 146, no. 11: 4887-97.

Gududuru, Veeresa; Hurh, Eunju; Dalton, James, T; Miller, Duane D. 2005. Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer. Journal of medicinal chemistry. Vol. 48, no. 7: 2584-8.

Gududuru, Veeresa; Hurh, Eunju; Sullivan, Joshua; Dalton, James, T; Miller, Duane D. 2005. SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: a novel class of cytotoxic agents for prostate cancer. Bioorganic & medicinal chemistry letters. Vol. 15, no. 18: 4010-3.

Kim, Juhyun; Wu, Di; Hwang, Dong Jin; Miller, Duane, D; Dalton, James T. 2005. The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators. The Journal of pharmacology and experimental therapeutics. Vol. 315, no. 1: 230-9.

Bhasin, Shalender; Calof, Olga, M; Storer, Thomas, W; Lee, Martin, L; Mazer, Norman, A; Jasuja, Ravi; Montori, Victor, M; Gao, Wenqing; Dalton, James T. 2006. Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nature clinical practice. Endocrinology & metabolism. Vol. 2, no. 3: 146-59.

Gao, Wenqing; Johnston, Jeffrey, S; Miller, Duane, D; Dalton, James T. 2006. Interspecies differences in pharmacokinetics and metabolism of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)-propionamide: the role of N-acetyltransferase. Drug metabolism and disposition: the biological fate of chemicals. Vol. 34, no. 2: 254-60.

Gao, Wenqing; Kim, Juhyun; Dalton, James T. 2006. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands. Pharmaceutical research. Vol. 23, no. 8: 1641-58.

Gao, Wenqing; Wu, Zengru; Bohl, Casey, E; Yang, Jun; Miller, Duane, D; Dalton, James T. 2006. Characterization of the in vitro metabolism of selective androgen receptor modulator using human, rat, and dog liver enzyme preparations. Drug metabolism and disposition: the biological fate of chemicals. Vol. 34, no. 2: 243-53.

George, Tesmol, G; Johnsamuel, Jayaseharan; Delfin, Dawn, A; Yakovich, Adam; Mukherjee, Mitali; Phelps, Mitch, A; Dalton, James, T; Sackett, Dan, L; Kaiser, Marcel; Brun, Reto; Werbovetz, Karl A. 2006. Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides. Bioorganic & medicinal chemistry. Vol. 14, no. 16: 5699-710.

Guan, Na; Korukonda, Rajani; Hurh, Eunju; Schmittgen, Thomas, D; Donkor, Isaac, O; Dalton, James T. 2006. Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. International journal of oncology. Vol. 29, no. 3: 655-63.

Hwang, Dong Jin; Yang, Jun; Xu, Huiping; Rakov, Igor, M; Mohler, Michael, L; Dalton, James, T; Miller, Duane D. 2006. Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer. Bioorganic & medicinal chemistry. Vol. 14, no. 19: 6525-38.

Korukonda, Rajani; Guan, Na; Dalton, James, T; Liu, Jiuyu; Donkor, Isaac O. 2006. Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides. Journal of medicinal chemistry. Vol. 49, no. 17: 5282-90.

Segal, Scott; Narayanan, Ramesh; Dalton, James T. 2006. Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery. Expert opinion on investigational drugs. Vol. 15, no. 4: 377-87.

Taneja, Samir, S; Smith, Matthew, R; Dalton, James, T; Raghow, Sharan; Barnette, Gary; Steiner, Mitchell; Veverka, Karen A. 2006. Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy. Expert opinion on investigational drugs. Vol. 15, no. 3: 293-305.

Wu, Di; George, Tesmol, G; Hurh, Eunju; Werbovetz, Karl, A; Dalton, James T. 2006. Pre-systemic metabolism prevents in vivo antikinetoplastid activity of N1,N4-substituted 3,5-dinitro sulfanilamide, GB-II-150. Life sciences. Vol. 79, no. 11: 1081-93.

Wu, Di; Wu, Zengru; Yang, Jun; Nair, Vipin, A; Miller, Duane, D; Dalton, James T. 2006. Pharmacokinetics and metabolism of a selective androgen receptor modulator in rats: implication of molecular properties and intensive metabolic profile to investigate ideal pharmacokinetic characteristics of a propanamide in preclinical study. Drug metabolism and disposition: the biological fate of chemicals. Vol. 34, no. 3: 483-94.

Wu, Zengru; Xing, Xu; Bohl, Casey, E; Wisler, James, W; Dalton, James, T; Bell, Charles E. 2006. Domain structure and DNA binding regions of beta protein from bacteriophage lambda. The Journal of biological chemistry. Vol. 281, no. 35: 25205-14.

Yang, Jun; Bohl, Casey, E; Nair, Vipin, A; Mustafa, Suni, M; Hong, Seoung Soo; Miller, Duane, D; Dalton, James T. 2006. Preclinical pharmacology of a nonsteroidal ligand for androgen receptor-mediated imaging of prostate cancer. The Journal of pharmacology and experimental therapeutics. Vol. 317, no. 1: 402-8.

Bohl, Casey, E; Wu, Zengru; Miller, Duane, D; Bell, Charles, E; Dalton, James T. 2007. Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. The Journal of biological chemistry. Vol. 282, no. 18: 13648-55.

Byrd, John, C; Lin, Thomas, S; Dalton, James, T; Wu, Di; Phelps, Mitch, A; Fischer, Beth; Moran, Mollie; Blum, Kristie, A; Rovin, Brad; Brooker-McEldowney, Michelle; Broering, Sarah; Schaaf, Larry, J; Johnson, Amy, J; Lucas, David, M; Heerema, Nyla, A; Lozanski, Gerard; Young, Donn, C; Suarez, Jose-Ramon; Colevas, A Dimitrios; Grever, Michael R. 2007. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood. Vol. 109, no. 2: 399-404.

Fang, Lanyan; Holford, Nicholas H, G; Hinkle, George; Cao, Xianhua; Xiao, Jim, J; Bloomston, Mark; Gibbs, Seth; Saif, Osama Habib Al; Dalton, James, T; Chan, Kenneth, K; Schlom, Jeffery; Martin, Edward W Jr; Sun, Duxin. 2007. Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients. Journal of clinical pharmacology. Vol. 47, no. 2: 227-37.

Gao, Wenqing; Dalton, James T. 2007. Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs). Drug discovery today. Vol. 12, no. 5-6: 241-8.

Gao, Wenqing; Dalton, James T. 2007. Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase?. Molecular interventions. Vol. 7, no. 1: 10-3.

Kearbey, Jeffrey, D; Gao, Wenqing; Narayanan, Ramesh; Fisher, Scott, J; Wu, Di; Miller, Duane, D; Dalton, James T. 2007. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharmaceutical research. Vol. 24, no. 2: 328-35.

Li, Wei; Lu, Yan; Wang, Zhao; Dalton, James, T; Miller, Duane D. 2007. Synthesis and antiproliferative activity of thiazolidine analogs for melanoma. Bioorganic & medicinal chemistry letters. Vol. 17, no. 15: 4113-7.

Li, Wei; Wang, Zhao; Gududuru, Veeresa; Zbytek, Blazej; Slominski, Andrzej, T; Dalton, James, T; Miller, Duane D. 2007. Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. Anticancer research. Vol. 27, no. 2: 883-8.

Sharifi, Nima; Hamel, Ernest; Lill, Markus, A; Risbood, Prabhakar; Kane, Charles T Jr; Hossain, Md Tafazzal; Jones, Amanda; Dalton, James, T; Farrar, William L. 2007. A bifunctional colchicinoid that binds to the androgen receptor. Molecular cancer therapeutics. Vol. 6, no. 8: 2328-36.

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