OSU:pro

Current OSU Appointments

Associate Professor, Heart and Lung Institute

Assistant Professor, Molecular & Cellular Biochemistry

Biographical Narrative

I graduated with a Diploma in Agricultural Chemistry from the National Taiwan University in Taipei, Taiwan, in 1986. After two-year mandatory military service, I retired at the Rank of Staff Sergeant from the Army of Taiwan. I was awarded a Scholarship for graduate studies at Oklahoma State University, Stillwater, OK. After receiving my Ph.D. degree in Biochemistry & Molecular Biology, I joined the Department of Biochemistry & Molecular Biology as a Research Associate. I joined the National Institute of Environmental Health Sciences (NIEHS) at Research Triangle Park, NC in 1997 as an IRTA (Intramural Research Training Award) fellow.

Following postdoctoral training, I accepted an offer for an Assistant Professor (tenure track) position in the Department of Internal Medicine (Cardiology) in 2002, and joined the world-renown for its excellence in Cardiovascular Research Davis Heart and Lung Research Institute at the Ohio State University in Columbus, OH. On the December of 2007, I was promoted to Associate Professor with tenure. Soon after my hire in OSU, I was awarded my first grant award (K22) from the National Institutes of Health (NIH) and my second grant (beginning grant in aid) from American Heart Association at the following year (2003), and, I was awarded my first NIH Ro1 grant at the year of 2006. Although I have my tenure initiating unit in the Division of Cardiovascular Medicine, I still maintain the joint appointment with the Department of Molecular and Cellular Biochemistry, College of Medicine. The double affiliation fits my research interests, which are at the interface between cardiology, biochemistry, and cell biology. Specifically, my research expertise and interests are in the areas of: myocardial ischemia, reperfusion injury, oxygen free radical(s), nitric oxide, and mitochondrial biology.

Currently, I am a departmental faculty of Internal Medicine, an investigator at the Davis Heart & Lung Research Institute, and an affiliated faculty member of the Integrated Biomedical Graduate Program, the Biophysics Graduate Program and the Mitochondrial Biology Institute at the Ohio State University. I direct the Mitochondrial Biology Laboratory at the Davis Heart & Lung Research Institute and am devoted to training pre-med students and graduate students of Biophysics Graduate Program at large. My funding was come primarily from NIH, but also from AHA. I have been a member of Program Project Grant (PPG) Committee at NIH/National Heart, Lung & Blood Institute (NHLBI) since 2007. I have been a member of study section (Cardiac Regulation) of AHA since 2008. I serve as Ad hoc/regular reviewer of several important journals in the scientific community of biophysics, biochemistry, and physiology, and I publish my research in a number of journals related to the biochemistry, heart and circulatory physiology.

Chapters In Books

Yeong-Renn Chen. 2008. EPR Spin-trapping and Nano LC MS/MS Techniques for DEPMPO/OOH and Immunospin-trapping with Anti-DMPO Antibody in Mitochondrial Electron Transport System. In Advanced Protocols for Oxidant Stress I, Methods in Molecular Biology.. Vol. 477. Edited by Donald Armstrong. New York, NY, USA: Humana Press. 75-88. DOI: 10.1007/978-1-60327-517-7.

Degrees

1986	B.S., National Taiwan University, Agricultural Chemistry

1994	Ph.D., Oklahoma State University, Biochemistry

Honors

1994	Honorable Mention Students of Research Excellence Awards. Oklahoma State University, Oklahoma City, OK, United States.

Peer Reviewed Journal Articles

Chen YR, Chen CL, Yeh A, Liu X, Zweier JL. 2006. Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase. J Biol Chem.. Vol. 281. (May 12): 13159-13168. doi:10.1074/jbc.M513627200.

Han Z, Chen Y-R, Jones C 3rd, Meenakshisundaram G, Zweier J, Alevriadou BR. 2007. Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells. Am J Physiol Cell Physiol. Vol. 292, no. 3. (March 1): C1103-12. (IF: 4.334)

Zhao X, Chen Y-R, He G, Zhang A, Druhan LJ, Strauch AR, Zweier JL. 2007. Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart. Am J Physiol Heart Circ Physiol. Vol. 292, no. 3. (March 1): H1541-50. (IF: 3.724)

Chen C-L, Zhang L, Yeh A, Chen C-A, Green-Church KB, Zweier JL, Chen Y-R. 2007. Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase. Biochemistry. Vol. 46, no. 19. (April 20): 5754-65. (IF: 3.633)

Zhu X, Liu B, Zhou S, Chen Y-R, Deng Y, Zweier JL, He G. 2007. Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption. Am J Physiol Heart Circ Physiol. Vol. 293, no. 3. (September 1): H1442-50. (IF: 3.724)

Chen Y-R, Chen C-L, Pfeiffer DR, Zweier JL. 2007. Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathiolation. J Biol Chem. Vol. 282, no. 45. (November 9): 32640-32654. (IF: 5.808)

Chen C-A, Druhan LJ, Varadharaj S, Chen Y-R, Zweier JL. 2008. Phosphorylation of Endothelial Nitric Oxide Synthase (eNOS) Increases Superoxide Generation From The Enzyme. J. Biol. Chem. Vol. 283. (October 3): 27038-27047. (IF: 5.581)

Chen C-L, Chen J, Varadharaj S, Rawale S, Kaumaya P, Zweier JL, Chen Y-R. 2008. Protein Tyrosine Nitration of Flavin Subunit Is Associated With Oxidative Modification Of Mitochondrial Complex II In The Post-ischemic Myocardium. J. Biol. Chem. Vol. 283, no. 41. (October 10): 27991-28003. (IF: 5.581)

Zhang L, Xu H, Chen C-L, Green-Church KB, Freitas MA, Chen Y-R. 2008. Mass Spectrometry Profiles Superoxide-induced Formation of Mixed Intra-molecular Protein Disulfide on the FMN-binding Subunit of Mitochondrial Complex I. J. Amer. Soc. of Mass Spectrom. Vol. 19. (December 1): 1875-1886. (IF: 3.664)

Bin Liu, Arun K. Tewari, Liwen Zhang, Kari B. Green-Church, Jay L. Zweier, Yeong-Renn Chen and Guanglong He. 2009. Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target. Biochimica et Biophysica Acta - Proteins and Proteomics. Vol. 1794, no. 3. (March 1): 476-485. doi:10.1016/j.bbapap.2008.12.008. (IF: 3.078)

Zuo L, Chen Y-R, Chen C-L, Villamena FA, Zweier JL. The Radical Trap 5,5-Dimethyl-1-pyrroline N-oxide Exerts Dose-Dependent Protection Against Myocardial Ischemia-Reperfusion Injury Through Preservation of Mitochondrial Electron Transport. J. Pharmacology and Experimental Therapeutics. (IF: 4.003) (In press)

Positions

1988 - 1989

Research Assistant, National Taiwan University, Taipei, Taiwan, School of Pharmacy,. Taipei, Taiwan.

1989 - 1994

Graduate Research Assistant, Oklahoma State University, Stillwater, OK, Department of Biochemistry and Molecular Biology. Stillwater, Oklahoma.

1994 - 1997

Research Associate, Oklahoma State University, Stillwater, OK, Department of Biochemistry and Molecular Biology. Stillwater, Oklahoma.

1997 - 2002

IRTA Fellowship, NIEHS, Research Triangle Park, NC, National Institutes of Health. Triangle Park, North Carolina.

2002 - 2007

Assistant Professor, The Ohio State University, Medicine, Internal Medicine. Columbus, OH, United States.

2007 - present

Associate Professor, The Ohio State University, Medicine, Internal Medicine. Columbus, OH, United States.

Undergrad., Grad. and Prof. Courses Taught

Winter 2008. The Ohio State University, Pharmacology. Cardiovascular Pharmacology Pharmacy 748. 3 credit hours

Spring 2008. The Ohio State University, Molecular and Cellular Biochemistry. Integrated Metabolism MCB 748. 3 credit hours