OSU:pro

Current OSU Appointment

Assistant Professor, Pediatrics

Peer Reviewed Journal Articles

Chandler, D., El-Naggar, A.K., Brisbay, S., Redline, R.W., McDonnell, T.J. 1994. Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney: Evidence for the contribution of bcl-2 expression to renal carcinogenesis.  Human Pathology, no. 25: 789-796.

Chandler, D., McGuffin, M.E., Piskur, J., Yao, J., Baker, B.S., Mattox, W. 1997. Evolutionary conservation of germline specific autoregulation by the sex determination factor transformer-2.  Molecular and Cellular Biology, no. 17: 2908-2919.

Pham, C.D., Runt, M., Chandler, D.S., Yang, Y., Arlinghaus, R.B., Rajagopalan, S., Schwartz, M.R., Singh, B. 1997. Essential role of c-Mos in eggs: reduced fertility and ovarian neoplasm in antisense mos transgenic mice.  International Journal of Gynecological Cancer, no. 7: 314-317.

McGuffin, M.E., Chandler, D.S., Somaiya, D., Dauwalder, B. and Mattox, W. 1998. Autoregulation of transformer-2 alternative splicing is necessary for normal male fertility in Drosophila.  Genetics. Vol. 149: 1477-1496.

Chandler, D.S., McGuffin, M.E., Mattox, W. 2001. Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre mRNA splicing.  Nucleic Acids Research. Vol. 14, no. 29: 3012-3019.

Lott, S.T., Chandler, D.S., Curley, S., Foster, C.J., El-Naggar, A., Frazier, M., Lovell, M.M., Strong, L.C. Killary, A.M. 2002. High Frequency Loss of Heterozygosity in von Hippel-Lindau (VHL)-Associated and Sporadic Pancreatic Islet Cell Tumors: Evidence for a Stepwise Mechanism for Malignant Conversion in VHL Tumorigenesis.  Cancer Research. Vol. 65: 1952-1955.

Chandler, D.S., Qi, J., and Mattox, W. 2003. Direct repression of splicing by transormer-2.  Molecular and Cellular Biology. Vol. 15, no. 23: 5174-5185.

Chandler, D.S., Singh, R.K., Caldwell, L.C., Bitler, J.L and Lozano, G. 2006. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.  Cancer Research. Vol. 66: 9502-9508.

Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC. 2008. NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. Vol. 14, no. 5. (November): 369-381. (IF: 23.858)

Jeyaraj, SC., O'Brien, D, and D. S. Chandler. 2009. MDM2 and MDM4 splicing: an integral part of the cancer spliceome. Frontiers in Bioscience, no. 14: 2647-2656.

Lott, S. T., Chen, N, Chandler, D. S., Yang, Q, Wang, L., Rodriguez, M., Xie, H., Balasenthil, S., Bucholz, T.A., Sahin, A., Chaung, K., Franya, A., Zhang, B., Olufemi, S., Chen, J., Adams, H., Keyomarsi, K., Band, V., El-Naggar, A.K., Sen, S., Hewitt, S. DEAR1 is a Dominant Regulator of Acinar Morphogenesis and Independent Predictor of Local Recurrence-Free Survival in Early Onset Breast Cancer.  PLoS Medicine. (In press)

Singh, R.K., Tapia-Santos, A., Bebee, T.W., Chandler, D.S. Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress.  Exp Cell Res, no. Epub ahead of print. (In press)

Gladman, J.T., Chandler, D.S. Intron 7 conserved sequence elements regulate the splicing of the SMN genes.  Hum Genet, no. Epub ahead of print. (In press)