Current OSU Appointment

Associate Professor, Molecular & Cellular Biochemistry

Degrees

1991	B.S.Chemistry, Bucknell University, Chemistry

1996	Ph.D., University of California, Los Angeles, Chemistry and Biochemistry

Honors

1990	Member. Bucknell University, Lewisburg, PA, United States.

1990	NSF Summer Research Program. Bucknell University, Lewisburg, PA, United States.

1992	Departmental Prize for Excellence.

1993 - 1995

Recipient.

1994	Bauer Prize.

1995 - 1996

Dissertation Year Fellowship.

1998 - 2000

Post-Doctoral Fellowship. University of Pennsylvania, Philadelphia, PA, United States.

Memberships

1993 - present

Member. Protein Society

1993 - present

Member. American Crystallographic Association

1994 - present

Member. Biophysical Society

1997 - present

Member. American Associate for the Advancement of Science

2001 - 2006

Member. The Ohio State University. Department of Molecular and Cellular Biochemistry Journal Club Comittee

2002 - 2003

Member. The Ohio State University. Department of Molecular and Cellular Biochemistry Faculty Search Committee

2002	Member. The Ohio State University. Biochemistry Department Faculty Search Committee

2003	Member. The Ohio State University. Denman Undergraduate Research Forum

2003	Member. The Ohio State University Medical Center. Graduate and Postgraduate Research Day

Peer Reviewed Journal Articles

Bell, Charles E.; Eisenberg, David. 1996. Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide. Biochemistry. Vol. 35, no. 4: 1137-1149.

Bell, Charles E.; Eisenberg, David. 1997. Crystal structure of nucleotide-free diphtheria toxin. Biochemistry. Vol. 36, no. 3: 481-488.

Bell, Charles E.; Poon, Pak H.; Schumaker, Verne N.; Eisenberg, David E. 1997. Oligomerization of a 45 kilodalton fragment of diphtheria toxin at ph 5.0 to a molecule of 20-24 subunits. Biochemistry. Vol. 36, no. 49: 15201-15207.

Bell, Charles E.; Yeates, Todd O.; Eisenberg, David. 1997. Unusual conformation of nicotinamide adenine dinucleotide (nad) bound to diphtheria toxin: A comparison with Nad bound to the oxidoreductase enzymes. Protein Science. Vol. 6, no. 10: 2084-2096.

Bell, Charles E.; Frescura, Paolo; Hochschild, Ann; Lewis, Mitchell. 2000. Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding. Cell. Vol. 101, no. 7: 801-811.

Bell, Charles E.; Lewis, Mitchell. 2000. A closer view of the conformation of the Lac repressor bound to operator. Nature Structural Biology. Vol. 7, no. 3: 209-214.

Bell, Charles E.; Barry, Jennifer; Matthews, Kathleen S.; Lewis, Mitchell. 2001. Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator. Journal of Molecular Biology. Vol. 313, no. 1: 99-109.

Bell, Charles E.; Lewis, Mitchell. 2001. Crystallographic analysis of Lac repressor bound to natural operator O1. Journal of Molecular Biology. Vol. 312, no. 5: 921-926.

Rajan, Rakhi; Bell, Charles E. 2004. Crystal structure of Reca from Deinococcus radiodurans: Insights into the structural basis of extreme radioresistance. Journal of Molecular Biology. Vol. 344, no. 4: 951-963.

Xing, Xu; Bell, Charles E. 2004. Crystal structures of Escherichia coli Reca in a compressed helical filament. Journal of Molecular Biology. Vol. 342, no. 5: 1471-1485.

Xing, Xu; Bell, Charles E. 2004. Crystal structures of Escherichia coli Reca in complex with Mgadp and Mnamp-pnp. Biochemistry. Vol. 43, no. 51: 16142-16152.

Bell, Charles E. 2005. Structure and mechanism of Escherichia coli Reca Atpase. Molecular Microbiology. Vol. 58, no. 2: 358-366.

Bohl, Casey E.; Gao, Wenqing; Miller, Duane D.; Bell, Charles E.; Dalton, James T. 2005. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. Vol. 102, no. 17: 6201-6206.

Bohl, Casey E.; Miller, Duane D.; Chen, Jiyun; Bell, Charles E.; Dalton, James T. 2005. Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. Journal of Biological Chemistry. Vol. 280, no. 45: 37747-37754. (IF: 5.808)

Rajan, Rakhi; Zhu, Jinge; Hu, Xubo; Pei, Dehua; Bell, Charles E. 2005. Crystal structure of S-ribosylhomocysteinase (luxs) in complex with a catalytic 2-ketone intermediate. Biochemistry. Vol. 44, no. 10: 3745-3753.

Ndjonka, Dieudonne; Bell, Charles E. 2006. Structure of a hyper-cleavable monomeric fragment of phage lambda repressor containing the cleavage site region. Journal of Molecular Biology. Vol. 362, no. 3: 479-489.

Rajan, Rakhi; Wisler, James W.; Bell, Charles E. 2006. Probing the Dna sequence specificity of Escherichia coli Reca protein. Nucleic Acids Research. Vol. 34, no. 8: 2463-2471.

Shen, Gang; Rajan, Rakhi; Zhu, Jinge; Bell, Charles E.; Pei, Dehua. 2006. Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase. Journal of Medicinal Chemistry. Vol. 49, no. 10: 3003-3011.

Wilson, Ross C.; Bohlen, Christopher J.; Foster, Mark P.; Bell, Charles E. 2006. Structure of Pfu Pop5, an archaeal Rnase P protein. Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 4: 873-878.

Wu, Zengru; Xing, Xu; Bohl, Casey E.; Wisler, James W.; Dalton, James T.; Bell, Charles E. 2006. Domain structure and Dna binding regions of beta protein from bacteriophage lambda. Journal of Biological Chemistry. Vol. 281, no. 35: 25205-25214.

Bohl CE, Wu Z, Miller DD, Bell CE, and Dalton JT. 2007. Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. Journal of Biological Chemistry. Vol. 282, no. 18. (May 4): 13648-13655. http://www.jbc.org/cgi/content/full/282/18/13648. (IF: 5.808)

Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang, DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. 2008. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bioorganic & Medicinal Chemistry Letters. Vol. 18(20):5567-70.

Pauff JM, Zhang J, Bell CE, Hille R. 2008. Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine. The Journal of Biological Chemistry. Vol. 283(8):4818-24.

Galkin VE; Yu X; Bielnicki J; Ndjonka D; Bell CE; Egelman EH. 2009. Cleavage of bacteriophage lambda cI repressor involves the RecA C-terminal domain. Journal Of Molecular Biology. Vol. 385, no. 3. (January 23): 779.

Gopishetty B; Zhu J; Rajan R; Sobczak AJ; Wnuk SF; Bell CE; Pei D. 2009. Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues. Journal Of The American Chemical Society. Vol. 131, no. 3. (January 28): 1243.

Zhang J; Xing X; Herr AB; Bell CE. 2009. Crystal Structure of E. coli RecE Protein Reveals a Toroidal Tetramer for Processing Double-Stranded DNA Breaks. Structure (London, England: 1993). Vol. 17, no. 5. (May 13): 690.

Positions

1997 - 2001

Postdoctoral Fellow, University of Pennsylvania, Department of Biochemistry and Biophysics. Philadelphia, PA, United States.

2001 - present

Faculty Member, The Ohio State University, Chemistry and Biology Interface Training Grant Program. Columbus, OH, United States.

2001 - present

Associate Member, The Ohio State University, Comprehensive Cancer Center, Molecular Biology and Cancer Genetics Program. Columbus, OH, United States.

Presentations

Other Presentations

Local

Dr. Charles E Bell. 1995. . Presented at West Coast Protein Crystallography Conference. Asilomar, California. (August 29)

Dr. Charles E Bell. 1995. . Presented at Conference on Mechanisms of ADP-Ribosylation. Hamburg, Germany. (August 29)

Dr. Charles E Bell. 1999. . Presented at Department of Chemistry, Bucknell University. Lewisburg, PA. (August 29)

Dr. Charles E Bell. 1999. . Presented at Department of Chemistry, University of Pennsylvania. Philadelphia, PA. (August 29)

Dr. Charles E Bell. 2000. . Presented at Department of Biochemistry and Biophysicsc, Washington University. (August 29)

Dr. Charles E Bell. 2000. . Presented at Department of Pharmacy, University of Maryland at Baltimore. Baltimore, MD. (August 29)

Dr. Charles E Bell. 2000. . Presented at Department of Biochemistry, University of Arizona. Tucson, AZ. (August 29)

Dr. Charles E Bell. 2000. . Presented at Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill. Chapel Hill, NC. (August 29)

Dr. Charles E Bell. 2000. . Presented at Department of Chemistry and Biochemistry, University of Colorado. Colorado. (August 29)

Dr. Charles E Bell. 2000. . Presented at Division of Biological Sciences, Fox Chase Cancer Center. Philadelphia, PA. (August 29)

Dr. Charles E Bell. 2001. . Presented at The Ohio State University, to Ohio State Biochemistry Program. Columbus, OH. (August 29)

Dr. Charles E Bell. 2003. . Presented at Comprehensive Cancer Center, The Ohio State University, to Molecular Biology and Cancer Genetics Program Retreat. Columbus, OH. (August 29)

Dr. Charles E Bell. 2004. . Presented at Ohio Macromolecular Crystallographic Consortium, University of Toledo. Toledo, OH. (August 29)

Dr. Charles E Bell. 2004. . Presented at Department of Biochemistry, The Ohio State University. Columbus, OH. (August 29)

Rakhi Rajan and Dr. Charles E Bell. 2005. Crystal structure of RecA from Deinococcus radiodurans: insights into the structural basis of extreme radioresistance. Presented at Keystone Conference: Mechanisms of DNA Replication of Recombination. Keystone, CO. (August 29)

Rakhi Rajan and Dr. Charles E Bell. 2005. Crystal structure of RecA from Deinococcus radiodurans: insights into the structure basis of extreme radioresistance. Presented at Biophysical Society Meeting. Long Beach, CA. (August 29)

Rakhi Rajan, James Wisler and Dr. Charles E Bell. 2005. Probing the sequence of E. coli RecA Protein. Presented at FASEB Meeting: Genetic Recombination and Genome Rearrangements. Snowmass, CO. (August 29)

Xu Xing and Dr. Charles E Bell. 2005. Crystal structures of E. Coli RecA bound to MgADP and MnAMP-PNP. Presented at Biophysical Society Meeting. Long Beach, CA. (August 29)

Dieudonne Ndjonka and Dr. Charles E Bell. 2006. Crystal structure of a cleavage-active conformation of phage lambda repressor. Presented at Keystone Symposium: Nucleic Acids Enzymes. Taos, NM. (August 29)

Dr. Charles E Bell. 2006. . Presented at Department of Biochemistry, University of Missouri. Columbia, MO. (August 29)

X Xing, Z Wu, JT Dalton and Dr. CE Bell. 2006. Domain structure and DNA binding regions of beta protein from bacteriophage lambda. Presented at Keystone Symposium: Nucleic Acids Enzymes. Tucson, AZ. (August 29)

Dr. Charles E Bell. 2007. . Presented at Department of Biochemistry, Dartmouth University. Hanover, NH. (August 29)

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