Current OSU Appointment

Associate Professor, Biomedical Engineering

Chapters In Books

Alevriadou BR, McIntire LV. 1994. Rheology. In Thrombosis and Hemorrhage. Edited by Loscalzo J, Schafer AI. Boston, MA: Blackwell Scientific Publications. 369-381.

Ross JM, Alevriadou BR, McIntire LV. 1998. Rheology. In Thrombosis and Hemorrhage. 2nd ed. ed. Edited by Loscalzo J, Schafer AI. Baltimore, MD: Williams & Wilkins. 405-421.

Degrees

1986	B.S., Aristotle University, Chemical Engineering

1992	Ph.D., Rice University, Chemical Engineering, Bioengineering & Biosciences

Editorial Activities

Editorial Board

American Journal of Physiology: Cell Physiology. (Article)

Manuscript Reviewer

American Journal of Physiology: Lung Cellular & Molecular Physiology. (Article)

Arteriosclerosis, Thrombosis and Vascular Biology. (Article)

Tissue Engineering.

Annals of Biomedical Engineering. (Article)

Critical Research in Toxicology. (Article)

ASME Journal of Biomechanical Engineering. (Article)

Journal of Biomechanics. (Article)

Computers and Fluids. (Article)

Microvascular Research. (Article)

Journal of Investigative Medicine. (Article)

Journal of Vascular Research.

Antioxidants & Redox Signaling.

Fellowship, Internship or Residency

1992 - 1993

Postdoctoral Fellowship, Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States.

Honors

1983 - 1986

Award for Undergraduate Academic Excellence. Technical Chamber of Greece. Aristotle University, Thessaloniki, Greece.

1986 - 1992

Graduate Fellowship. Robert A. Welch Foundation. Rice University, Houston, TX, United States.

1992	1st Prize, Graduate Student Symposium. Rice University. Rice University, Houston, TX, United States.

2003	Grant Reviewer (ad hoc). NIH/NHLBI. Subject: SBIR/STTR Study Section

2003 - 2007

Grant Reviewer (Member). NIH/NHLBI. Subject: Bioengineering, Technology & Surgical Sciences (BTSS) Study Section

Memberships

Member. Biomedical Engineering Society (BMES)

Member. American Institute of Chemical Engineers (AIChE)

Member. North American Vascular Biology Organization (NAVBO)

Member. Society for Free Radical Biology and Medicine (SFRBM)

Member. Phi Lambda Ypsilon. Honorary Chemical Society

Peer Reviewed Journal Articles

Alevriadou BR, McIntire LV, Lasslo A. 1992. Inhibition of platelet adhesion and thrombus formation on a collagen-coated surface by novel carbamoylpiperidine antiplatelet agents. Biochimica et Biophysica Acta. Vol. 1137, no. 3: 279-86.

Alevriadou BR, Eskin SG, McIntire LV, Schilling WP. 1993. Effect of shear stress on 86Rb+ efflux from calf pulmonary artery endothelial cells. Annals of Biomedical Engineering. Vol. 21, no. 1: 1-7.

Alevriadou BR, Moake JL, Turner NA, Ruggeri ZM, Folie BJ, Phillips MD, Schreiber AB, Hrinda ME, McIntire LV. 1993. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood. Vol. 81, no. 5: 1263-76.

Graham DA, Huang TC, Keyt BA, Alevriadou BR. 1998. Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow. Annals of Biomedical Engineering. Vol. 26, no. 4: 712-24.

Huang TC, Graham DA, Nelson LD, Alevriadou BR. 1998. Fibrinolytic agents inhibit platelet adhesion onto collagen type I-coated surfaces at high blood flow conditions. Blood Coagulation & Fibrinolysis. Vol. 9, no. 3: 213-26.

Yeh LH, Park YJ, Hansalia RJ, Ahmed IS, Deshpande SS, Goldschmidt-Clermont PJ, Irani K, Alevriadou BR. 1999. Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of reactive oxygen species. American Journal of Physiology - Cell Physiology. Vol. 276: C838-47.

Zablocki DK, Rade JJ, Alevriadou BR. 2000. Adenovirus-mediated expression of tissue plasminogen activator does not alter endothelial cell proliferation and invasion. In Vitro Cellular & Developmental Biology-Animal. Vol. 36, no. 10: 625-8.

Hinds MT, Park YJ, Jones SA, Giddens DP, Alevriadou BR. 2001. Local hemodynamics affect monocytic cell adhesion to a three-dimensional flow model coated with E-selectin. Journal of Biomechanics. Vol. 34, no. 1: 95-103.

Huang TC, Jordan RE, Hantgan RR, Alevriadou BR. 2001. Differential effects of c7E3 Fab on thrombus formation and rt-PA-Mediated thrombolysis under flow conditions. Thrombosis Research. Vol. 102, no. 5: 411-25.

Yeh LH, Kinsey AM, Chatterjee S, Alevriadou BR. 2001. Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression. Journal of Vascular Research. Vol. 38, no. 6: 551-9.

Ng CKD, Deshpande SS, Irani K, Alevriadou BR. 2002. Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1. American Journal of Physiology - Cell Physiology. Vol. 283, no. 1: C93-102.

Wootton DM, Popel AS, Alevriadou BR. 2002. An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator. Biotechnology and Bioengineering. Vol. 77, no. 4: 405-19.

Alevriadou BR. 2003. CAMs and Rho small GTPases: gatekeepers for leukocyte transendothelial migration. Focus on "VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration". American Journal of Physiology - Cell Physiology. Vol. 285, no. 2: C250-2.

Vijayan KV, Huang TC, Liu Y, Bernando A, Dong JF, Goldschmidt-Clermont PJ, Alevriadou BR, Bray PF. 2003. Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3. FEBS Letters. Vol. 540: 41-6.

Haun JB, Baldwin WM 3rd, Alevriadou BR. 2005. Clearance of complement by human vascular endothelial cells: effects of hypoxia/reoxygenation and IL-1beta activation. Transplant International. Vol. 18, no. 4: 475-82.

Martin SF, Chatterjee S, Parinandi N, Alevriadou BR. 2005. Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells. Vascular Pharmacology. Vol. 43, no. 3: 148-56.

Han Z, Jones CI 3rd, Alevriadou BR. 2006. Mitochondrial electron transport is required for the induction of heme oxygenase-1 protein in vascular endothelial cells exposed to shear stress. Free Radical Biology & Medicine. Vol. 41, no. Suppl. 1: S37.

Han Z, Chen Y-R, Jones CI 3rd, Meenakshisundaram G, Zweier JL, Alevriadou BR. 2007. Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells. American Journal of Physiology - Cell Physiology. Vol. 292, no. 3: C1103-12.

Jones CI 3rd, Han Z, Szeto HH, Alevriadou BR. 2007. Expression of heme oxygenase-1 in sheared vascular endothelial cells is regulated by mitochondrial H2O2 formation. Free Radical Biology & Medicine. Vol. 43, no. Suppl. 1: S151.

Jones CI 3rd, Zhu H, Martin SF, Han Z, Li Y, Alevriadou BR. 2007. Regulation of antioxidants and phase 2 enzymes by shear-induced reactive oxygen species in endothelial cells. Annals of Biomedical Engineering. Vol. 35, no. 5. (May): 683-693.

Jones CI 3rd, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR. 2008. Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite. American Journal of Physiology - Cell Physiology. Vol. 295, no. 1. (July): C180-91. (IF: 4.230)

Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR. Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. (IF: 4.003) (In press)

Positions

1983	Intern, Ethyl Hellas Company. Thessaloniki, Greece.

1984	Intern, S.I.C.N.G. Chemical Fertilizer Company. Thessaloniki, Greece.

1985 - 1986

Undergraduate Research Assistant, Aristotle University, Aristotle University, Department of Chemical Engineering. Thessaloniki, Greece.

1986 - 1992

Graduate Research Assistant, Rice University, Rice University, Bioengineering and Biosciences Institute, Department of Chemical Engineering. Houston, TX, United States.

1992 - 1993

Research Associate, The Scripps Research Institute, Department of Molecular and Experimental Medicine. La Jolla, CA.

1993 - 2003

Assistant Professor, Johns Hopkins University, School of Medicine, Johns Hopkins University, The Johns Hopkins University School of Medicine, Department of Biomedical Engineering. Baltimore, MD, United States.

2003 - present

Associate Professor, The Ohio State University, Departments of Biomedical Engineering and Internal Medicine (Cardiology). Columbus, OH, United States.

2003 - present

Investigator, The Ohio State University, Davis Heart & Lung Research Institute (DHLRI). Columbus, OH, United States.

2003 - present

Affiliated Faculty, The Ohio State University, Integrated Biomedical Science Graduate Program. Columbus, OH, United States.

2003 - present

Affiliated Faculty, The Ohio State University, Biophysics Graduate Program. Columbus, OH, United States.

2006 - present

Member, The Ohio State University, Institute of Mitochondrial Biology. Columbus, OH, United States.

2008 - present

Associate Professor with tenure, The Ohio State University, Departments of Biomedical Engineering and Internal Medicine (Cardiology). Columbus, OH, United States.

Undergrad., Grad. and Prof. Courses Taught

Spring 2004. The Ohio State University, BIOMEDICAL ENGINEERING. Fundamentals of Cell & Tissue Engineering 694. 3 credit hours, 50% Taught

Autumn 2005. The Ohio State University, Biomedical Engineering. Biological Transport BME 721. 3 credit hours, 50% Taught

Spring 2006. The Ohio State University, BIOMEDICAL ENGINEERING. Fundamentals of Cell & Tissue Engineering 694. 3 credit hours, 50% Taught

Autumn 2006. The Ohio State University, Biomedical Engineering. Biological Transport BME 721. 3 credit hours

Spring 2007. The Ohio State University, Biomedical Engineering. Fundamentals of Cell & Tissue Engineering BME 694. 3 credit hours, 50% Taught

Autumn 2007. The Ohio State University, Biomedical Engineering. Biological Transport BME 721. 3 credit hours

Autumn 2008. The Ohio State University, Biomedical Engineering. Cell Engineering for Biology and Medicine. BME 694. 3 credit hours

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